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A Critical Review of the Psychomotor Agitation Treatment in Youth

(1) Background: To systematically review evidence on the safety and efficacy of psychopharmacological treatments available for psychomotor agitation (PA) in children and adolescents. (2) Methods: Studies assessing the safety and efficacy of psychopharmacological treatments for acute PA in children a...

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Autores principales: Tripodi, Beniamino, Matarese, Irene, Carbone, Manuel Glauco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965751/
https://www.ncbi.nlm.nih.gov/pubmed/36836652
http://dx.doi.org/10.3390/life13020293
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author Tripodi, Beniamino
Matarese, Irene
Carbone, Manuel Glauco
author_facet Tripodi, Beniamino
Matarese, Irene
Carbone, Manuel Glauco
author_sort Tripodi, Beniamino
collection PubMed
description (1) Background: To systematically review evidence on the safety and efficacy of psychopharmacological treatments available for psychomotor agitation (PA) in children and adolescents. (2) Methods: Studies assessing the safety and efficacy of psychopharmacological treatments for acute PA in children and adolescents that were published between January 1984 and June 2022 on PubMed were systematically reviewed. We included: (i) papers that presented a combination of the search terms specified in the “Search strategy” sub-paragraph; (ii) manuscripts in English; (iii) original papers; (iv) prospective or retrospective/observational studies and experimental or quasi-experimental reports. The exclusion criteria were: (i) review papers; (ii) non-original studies including editorials and book reviews; (iii) studies not specifically designed and focused on the selected topic. (3) Results: We selected 42 papers: 11 case series (11/42, 26.19%), 8 chart reviews (8/42, 19.05%), 8 case reports (8/42, 19.05%), 6 double-blind placebo-controlled randomized studies (6/42, 14.29%), 4 double-blind controlled randomized studies (4/42, 9.52%), 4 open-label trials (4/42, 9.52%) and 1 case control (1/42, 2.38%). (4) Conclusions: The drugs most frequently used to treat agitation in children and adolescents were ziprasidone, risperidone, aripiprazole, olanzapine and valproic acid. Further studies are needed to evaluate the efficacy/safety ratio, considering the limited number of observations in this field.
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spelling pubmed-99657512023-02-26 A Critical Review of the Psychomotor Agitation Treatment in Youth Tripodi, Beniamino Matarese, Irene Carbone, Manuel Glauco Life (Basel) Systematic Review (1) Background: To systematically review evidence on the safety and efficacy of psychopharmacological treatments available for psychomotor agitation (PA) in children and adolescents. (2) Methods: Studies assessing the safety and efficacy of psychopharmacological treatments for acute PA in children and adolescents that were published between January 1984 and June 2022 on PubMed were systematically reviewed. We included: (i) papers that presented a combination of the search terms specified in the “Search strategy” sub-paragraph; (ii) manuscripts in English; (iii) original papers; (iv) prospective or retrospective/observational studies and experimental or quasi-experimental reports. The exclusion criteria were: (i) review papers; (ii) non-original studies including editorials and book reviews; (iii) studies not specifically designed and focused on the selected topic. (3) Results: We selected 42 papers: 11 case series (11/42, 26.19%), 8 chart reviews (8/42, 19.05%), 8 case reports (8/42, 19.05%), 6 double-blind placebo-controlled randomized studies (6/42, 14.29%), 4 double-blind controlled randomized studies (4/42, 9.52%), 4 open-label trials (4/42, 9.52%) and 1 case control (1/42, 2.38%). (4) Conclusions: The drugs most frequently used to treat agitation in children and adolescents were ziprasidone, risperidone, aripiprazole, olanzapine and valproic acid. Further studies are needed to evaluate the efficacy/safety ratio, considering the limited number of observations in this field. MDPI 2023-01-20 /pmc/articles/PMC9965751/ /pubmed/36836652 http://dx.doi.org/10.3390/life13020293 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Tripodi, Beniamino
Matarese, Irene
Carbone, Manuel Glauco
A Critical Review of the Psychomotor Agitation Treatment in Youth
title A Critical Review of the Psychomotor Agitation Treatment in Youth
title_full A Critical Review of the Psychomotor Agitation Treatment in Youth
title_fullStr A Critical Review of the Psychomotor Agitation Treatment in Youth
title_full_unstemmed A Critical Review of the Psychomotor Agitation Treatment in Youth
title_short A Critical Review of the Psychomotor Agitation Treatment in Youth
title_sort critical review of the psychomotor agitation treatment in youth
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965751/
https://www.ncbi.nlm.nih.gov/pubmed/36836652
http://dx.doi.org/10.3390/life13020293
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