Toxicological Assessments of a Pandemic COVID-19 Vaccine—Demonstrating the Suitability of a Platform Approach for mRNA Vaccines

The emergence of SARS-CoV-2 at the end of 2019 required the swift development of a vaccine to address the pandemic. Nonclinical GLP-compliant studies in Wistar Han rats were initiated to assess the local tolerance, systemic toxicity, and immune response to four mRNA vaccine candidates encoding immun...

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Autores principales: Rohde, Cynthia M., Lindemann, Claudia, Giovanelli, Michael, Sellers, Rani S., Diekmann, Jan, Choudhary, Shambhunath, Ramaiah, Lila, Vogel, Annette B., Chervona, Yana, Muik, Alexander, Sahin, Ugur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965811/
https://www.ncbi.nlm.nih.gov/pubmed/36851293
http://dx.doi.org/10.3390/vaccines11020417

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