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Putative Mitoviruses without In-Frame UGA(W) Codons: Evolutionary Implications
Mitoviruses are small vertically transmitted RNA viruses found in fungi, plants and animals. Taxonomically, a total of 105 species and 4 genera have been formally recognized by ICTV, and recently, 18 new putative species have been included in a new proposed genus. Transcriptomic and metatranscriptom...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965874/ https://www.ncbi.nlm.nih.gov/pubmed/36851553 http://dx.doi.org/10.3390/v15020340 |
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author | Jacquat, Andrés Gustavo Theumer, Martín Gustavo Dambolena, José Sebastián |
author_facet | Jacquat, Andrés Gustavo Theumer, Martín Gustavo Dambolena, José Sebastián |
author_sort | Jacquat, Andrés Gustavo |
collection | PubMed |
description | Mitoviruses are small vertically transmitted RNA viruses found in fungi, plants and animals. Taxonomically, a total of 105 species and 4 genera have been formally recognized by ICTV, and recently, 18 new putative species have been included in a new proposed genus. Transcriptomic and metatranscriptomic studies are a major source of countless new virus-like sequences that are continually being added to open databases and these may be good sources for identifying new putative mitoviruses. The search for mitovirus-like sequences in the NCBI databases resulted in the discovery of more than one hundred new putative mitoviruses, with important implications for taxonomy and also for the evolutionary scenario. Here, we propose the inclusion of four new putative members to the genus Kvaramitovirus, and the existence of a new large basally divergent lineage composed of 144 members that lack internal UGA codons (subfamily “Arkeomitovirinae”), a feature not shared by the vast majority of mitoviruses. Finally, a taxonomic categorization proposal and a detailed description of the evolutionary history of mitoviruses were carried out. This in silico study supports the hypothesis of the existence of a basally divergent lineage that could have had an impact on the early evolutionary history of mitoviruses. |
format | Online Article Text |
id | pubmed-9965874 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99658742023-02-26 Putative Mitoviruses without In-Frame UGA(W) Codons: Evolutionary Implications Jacquat, Andrés Gustavo Theumer, Martín Gustavo Dambolena, José Sebastián Viruses Article Mitoviruses are small vertically transmitted RNA viruses found in fungi, plants and animals. Taxonomically, a total of 105 species and 4 genera have been formally recognized by ICTV, and recently, 18 new putative species have been included in a new proposed genus. Transcriptomic and metatranscriptomic studies are a major source of countless new virus-like sequences that are continually being added to open databases and these may be good sources for identifying new putative mitoviruses. The search for mitovirus-like sequences in the NCBI databases resulted in the discovery of more than one hundred new putative mitoviruses, with important implications for taxonomy and also for the evolutionary scenario. Here, we propose the inclusion of four new putative members to the genus Kvaramitovirus, and the existence of a new large basally divergent lineage composed of 144 members that lack internal UGA codons (subfamily “Arkeomitovirinae”), a feature not shared by the vast majority of mitoviruses. Finally, a taxonomic categorization proposal and a detailed description of the evolutionary history of mitoviruses were carried out. This in silico study supports the hypothesis of the existence of a basally divergent lineage that could have had an impact on the early evolutionary history of mitoviruses. MDPI 2023-01-25 /pmc/articles/PMC9965874/ /pubmed/36851553 http://dx.doi.org/10.3390/v15020340 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jacquat, Andrés Gustavo Theumer, Martín Gustavo Dambolena, José Sebastián Putative Mitoviruses without In-Frame UGA(W) Codons: Evolutionary Implications |
title | Putative Mitoviruses without In-Frame UGA(W) Codons: Evolutionary Implications |
title_full | Putative Mitoviruses without In-Frame UGA(W) Codons: Evolutionary Implications |
title_fullStr | Putative Mitoviruses without In-Frame UGA(W) Codons: Evolutionary Implications |
title_full_unstemmed | Putative Mitoviruses without In-Frame UGA(W) Codons: Evolutionary Implications |
title_short | Putative Mitoviruses without In-Frame UGA(W) Codons: Evolutionary Implications |
title_sort | putative mitoviruses without in-frame uga(w) codons: evolutionary implications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965874/ https://www.ncbi.nlm.nih.gov/pubmed/36851553 http://dx.doi.org/10.3390/v15020340 |
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