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Putative Mitoviruses without In-Frame UGA(W) Codons: Evolutionary Implications

Mitoviruses are small vertically transmitted RNA viruses found in fungi, plants and animals. Taxonomically, a total of 105 species and 4 genera have been formally recognized by ICTV, and recently, 18 new putative species have been included in a new proposed genus. Transcriptomic and metatranscriptom...

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Autores principales: Jacquat, Andrés Gustavo, Theumer, Martín Gustavo, Dambolena, José Sebastián
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965874/
https://www.ncbi.nlm.nih.gov/pubmed/36851553
http://dx.doi.org/10.3390/v15020340
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author Jacquat, Andrés Gustavo
Theumer, Martín Gustavo
Dambolena, José Sebastián
author_facet Jacquat, Andrés Gustavo
Theumer, Martín Gustavo
Dambolena, José Sebastián
author_sort Jacquat, Andrés Gustavo
collection PubMed
description Mitoviruses are small vertically transmitted RNA viruses found in fungi, plants and animals. Taxonomically, a total of 105 species and 4 genera have been formally recognized by ICTV, and recently, 18 new putative species have been included in a new proposed genus. Transcriptomic and metatranscriptomic studies are a major source of countless new virus-like sequences that are continually being added to open databases and these may be good sources for identifying new putative mitoviruses. The search for mitovirus-like sequences in the NCBI databases resulted in the discovery of more than one hundred new putative mitoviruses, with important implications for taxonomy and also for the evolutionary scenario. Here, we propose the inclusion of four new putative members to the genus Kvaramitovirus, and the existence of a new large basally divergent lineage composed of 144 members that lack internal UGA codons (subfamily “Arkeomitovirinae”), a feature not shared by the vast majority of mitoviruses. Finally, a taxonomic categorization proposal and a detailed description of the evolutionary history of mitoviruses were carried out. This in silico study supports the hypothesis of the existence of a basally divergent lineage that could have had an impact on the early evolutionary history of mitoviruses.
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spelling pubmed-99658742023-02-26 Putative Mitoviruses without In-Frame UGA(W) Codons: Evolutionary Implications Jacquat, Andrés Gustavo Theumer, Martín Gustavo Dambolena, José Sebastián Viruses Article Mitoviruses are small vertically transmitted RNA viruses found in fungi, plants and animals. Taxonomically, a total of 105 species and 4 genera have been formally recognized by ICTV, and recently, 18 new putative species have been included in a new proposed genus. Transcriptomic and metatranscriptomic studies are a major source of countless new virus-like sequences that are continually being added to open databases and these may be good sources for identifying new putative mitoviruses. The search for mitovirus-like sequences in the NCBI databases resulted in the discovery of more than one hundred new putative mitoviruses, with important implications for taxonomy and also for the evolutionary scenario. Here, we propose the inclusion of four new putative members to the genus Kvaramitovirus, and the existence of a new large basally divergent lineage composed of 144 members that lack internal UGA codons (subfamily “Arkeomitovirinae”), a feature not shared by the vast majority of mitoviruses. Finally, a taxonomic categorization proposal and a detailed description of the evolutionary history of mitoviruses were carried out. This in silico study supports the hypothesis of the existence of a basally divergent lineage that could have had an impact on the early evolutionary history of mitoviruses. MDPI 2023-01-25 /pmc/articles/PMC9965874/ /pubmed/36851553 http://dx.doi.org/10.3390/v15020340 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jacquat, Andrés Gustavo
Theumer, Martín Gustavo
Dambolena, José Sebastián
Putative Mitoviruses without In-Frame UGA(W) Codons: Evolutionary Implications
title Putative Mitoviruses without In-Frame UGA(W) Codons: Evolutionary Implications
title_full Putative Mitoviruses without In-Frame UGA(W) Codons: Evolutionary Implications
title_fullStr Putative Mitoviruses without In-Frame UGA(W) Codons: Evolutionary Implications
title_full_unstemmed Putative Mitoviruses without In-Frame UGA(W) Codons: Evolutionary Implications
title_short Putative Mitoviruses without In-Frame UGA(W) Codons: Evolutionary Implications
title_sort putative mitoviruses without in-frame uga(w) codons: evolutionary implications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965874/
https://www.ncbi.nlm.nih.gov/pubmed/36851553
http://dx.doi.org/10.3390/v15020340
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