A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug–Drug Interaction Perpetrators

The antifungal ketoconazole, which is mainly used for dermal infections and treatment of Cushing’s syndrome, is prone to drug–food interactions (DFIs) and is well known for its strong drug–drug interaction (DDI) potential. Some of ketoconazole’s potent inhibitory activity can be attributed to its me...

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Detalles Bibliográficos
Autores principales: Marok, Fatima Zahra, Wojtyniak, Jan-Georg, Fuhr, Laura Maria, Selzer, Dominik, Schwab, Matthias, Weiss, Johanna, Haefeli, Walter Emil, Lehr, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965990/
https://www.ncbi.nlm.nih.gov/pubmed/36840001
http://dx.doi.org/10.3390/pharmaceutics15020679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965990/
https://www.ncbi.nlm.nih.gov/pubmed/36840001
http://dx.doi.org/10.3390/pharmaceutics15020679

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