Cargando…
A Machine Learning Approach for PLGA Nanoparticles in Antiviral Drug Delivery
In recent years, nanoparticles have been highly investigated in the laboratory. However, only a few laboratory discoveries have been translated into clinical practice. These findings in the laboratory are limited by trial-and-error methods to determine the optimum formulation for successful drug del...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966002/ https://www.ncbi.nlm.nih.gov/pubmed/36839817 http://dx.doi.org/10.3390/pharmaceutics15020495 |
_version_ | 1784896907603083264 |
---|---|
author | Noorain, Labiba Nguyen, Vu Kim, Hae-Won Nguyen, Linh T. B. |
author_facet | Noorain, Labiba Nguyen, Vu Kim, Hae-Won Nguyen, Linh T. B. |
author_sort | Noorain, Labiba |
collection | PubMed |
description | In recent years, nanoparticles have been highly investigated in the laboratory. However, only a few laboratory discoveries have been translated into clinical practice. These findings in the laboratory are limited by trial-and-error methods to determine the optimum formulation for successful drug delivery. A new paradigm is required to ease the translation of lab discoveries to clinical practice. Due to their previous success in antiviral activity, it is vital to accelerate the discovery of novel drugs to treat and manage viruses. Machine learning is a subfield of artificial intelligence and consists of computer algorithms which are improved through experience. It can generate predictions from data inputs via an algorithm which includes a method built from inputs and outputs. Combining nanotherapeutics and well-established machine-learning algorithms can simplify antiviral-drug development systems by automating the analysis. Other relationships in bio-pharmaceutical networks would eventually aid in reaching a complex goal very easily. From previous laboratory experiments, data can be extracted and input into machine learning algorithms to generate predictions. In this study, poly (lactic-co-glycolic acid) (PLGA) nanoparticles were investigated in antiviral drug delivery. Data was extracted from research articles on nanoparticle size, polydispersity index, drug loading capacity and encapsulation efficiency. The Gaussian Process, a form of machine learning algorithm, could be applied to this data to generate graphs with predictions of the datasets. The Gaussian Process is a probabilistic machine learning model which defines a prior over function. The mean and variance of the data can be calculated via matrix multiplications, leading to the formation of prediction graphs—the graphs generated in this study which could be used for the discovery of novel antiviral drugs. The drug load and encapsulation efficiency of a nanoparticle with a specific size can be predicted using these graphs. This could eliminate the trial-and-error discovery method and save laboratory time and ease efficiency. |
format | Online Article Text |
id | pubmed-9966002 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99660022023-02-26 A Machine Learning Approach for PLGA Nanoparticles in Antiviral Drug Delivery Noorain, Labiba Nguyen, Vu Kim, Hae-Won Nguyen, Linh T. B. Pharmaceutics Article In recent years, nanoparticles have been highly investigated in the laboratory. However, only a few laboratory discoveries have been translated into clinical practice. These findings in the laboratory are limited by trial-and-error methods to determine the optimum formulation for successful drug delivery. A new paradigm is required to ease the translation of lab discoveries to clinical practice. Due to their previous success in antiviral activity, it is vital to accelerate the discovery of novel drugs to treat and manage viruses. Machine learning is a subfield of artificial intelligence and consists of computer algorithms which are improved through experience. It can generate predictions from data inputs via an algorithm which includes a method built from inputs and outputs. Combining nanotherapeutics and well-established machine-learning algorithms can simplify antiviral-drug development systems by automating the analysis. Other relationships in bio-pharmaceutical networks would eventually aid in reaching a complex goal very easily. From previous laboratory experiments, data can be extracted and input into machine learning algorithms to generate predictions. In this study, poly (lactic-co-glycolic acid) (PLGA) nanoparticles were investigated in antiviral drug delivery. Data was extracted from research articles on nanoparticle size, polydispersity index, drug loading capacity and encapsulation efficiency. The Gaussian Process, a form of machine learning algorithm, could be applied to this data to generate graphs with predictions of the datasets. The Gaussian Process is a probabilistic machine learning model which defines a prior over function. The mean and variance of the data can be calculated via matrix multiplications, leading to the formation of prediction graphs—the graphs generated in this study which could be used for the discovery of novel antiviral drugs. The drug load and encapsulation efficiency of a nanoparticle with a specific size can be predicted using these graphs. This could eliminate the trial-and-error discovery method and save laboratory time and ease efficiency. MDPI 2023-02-02 /pmc/articles/PMC9966002/ /pubmed/36839817 http://dx.doi.org/10.3390/pharmaceutics15020495 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Noorain, Labiba Nguyen, Vu Kim, Hae-Won Nguyen, Linh T. B. A Machine Learning Approach for PLGA Nanoparticles in Antiviral Drug Delivery |
title | A Machine Learning Approach for PLGA Nanoparticles in Antiviral Drug Delivery |
title_full | A Machine Learning Approach for PLGA Nanoparticles in Antiviral Drug Delivery |
title_fullStr | A Machine Learning Approach for PLGA Nanoparticles in Antiviral Drug Delivery |
title_full_unstemmed | A Machine Learning Approach for PLGA Nanoparticles in Antiviral Drug Delivery |
title_short | A Machine Learning Approach for PLGA Nanoparticles in Antiviral Drug Delivery |
title_sort | machine learning approach for plga nanoparticles in antiviral drug delivery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966002/ https://www.ncbi.nlm.nih.gov/pubmed/36839817 http://dx.doi.org/10.3390/pharmaceutics15020495 |
work_keys_str_mv | AT noorainlabiba amachinelearningapproachforplgananoparticlesinantiviraldrugdelivery AT nguyenvu amachinelearningapproachforplgananoparticlesinantiviraldrugdelivery AT kimhaewon amachinelearningapproachforplgananoparticlesinantiviraldrugdelivery AT nguyenlinhtb amachinelearningapproachforplgananoparticlesinantiviraldrugdelivery AT noorainlabiba machinelearningapproachforplgananoparticlesinantiviraldrugdelivery AT nguyenvu machinelearningapproachforplgananoparticlesinantiviraldrugdelivery AT kimhaewon machinelearningapproachforplgananoparticlesinantiviraldrugdelivery AT nguyenlinhtb machinelearningapproachforplgananoparticlesinantiviraldrugdelivery |