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Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility

Oxidative stress (OS) plays an important role in a variety of physiological and pathological processes of the female reproductive system. In recent years the relationship between OS and endometriosis has been of particular interest, and a theory has been suggested that OS may be a cause of endometri...

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Autores principales: Didziokaite, Gabija, Biliute, Gabija, Gudaite, Jogaile, Kvedariene, Violeta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966009/
https://www.ncbi.nlm.nih.gov/pubmed/36835217
http://dx.doi.org/10.3390/ijms24043809
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author Didziokaite, Gabija
Biliute, Gabija
Gudaite, Jogaile
Kvedariene, Violeta
author_facet Didziokaite, Gabija
Biliute, Gabija
Gudaite, Jogaile
Kvedariene, Violeta
author_sort Didziokaite, Gabija
collection PubMed
description Oxidative stress (OS) plays an important role in a variety of physiological and pathological processes of the female reproductive system. In recent years the relationship between OS and endometriosis has been of particular interest, and a theory has been suggested that OS may be a cause of endometriosis development. While the link between endometriosis and infertility is well established, minimal or mild stages of endometriosis are not considered to cause infertility. Increasing evidence of OS as a leading agent in the development of endometriosis has brought up a theory of minimal/mild endometriosis itself being one of the manifestations of high OS rather than a separate disease which directly causes infertility. Moreover, further development of the disease is thought to contribute to an increased production of reactive oxygen species (ROS) thus leading to the progression of endometriosis itself as well as to other pathological processes in the female reproductive system. Therefore, in case of minimal or mild endometriosis, the less invasive treatment could be offered in order to stop the ongoing cycle of endometriosis-reinforced excess ROS production and to reduce their harmful effects. In this article the existing connection between OS, endometriosis, and infertility is explored.
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spelling pubmed-99660092023-02-26 Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility Didziokaite, Gabija Biliute, Gabija Gudaite, Jogaile Kvedariene, Violeta Int J Mol Sci Review Oxidative stress (OS) plays an important role in a variety of physiological and pathological processes of the female reproductive system. In recent years the relationship between OS and endometriosis has been of particular interest, and a theory has been suggested that OS may be a cause of endometriosis development. While the link between endometriosis and infertility is well established, minimal or mild stages of endometriosis are not considered to cause infertility. Increasing evidence of OS as a leading agent in the development of endometriosis has brought up a theory of minimal/mild endometriosis itself being one of the manifestations of high OS rather than a separate disease which directly causes infertility. Moreover, further development of the disease is thought to contribute to an increased production of reactive oxygen species (ROS) thus leading to the progression of endometriosis itself as well as to other pathological processes in the female reproductive system. Therefore, in case of minimal or mild endometriosis, the less invasive treatment could be offered in order to stop the ongoing cycle of endometriosis-reinforced excess ROS production and to reduce their harmful effects. In this article the existing connection between OS, endometriosis, and infertility is explored. MDPI 2023-02-14 /pmc/articles/PMC9966009/ /pubmed/36835217 http://dx.doi.org/10.3390/ijms24043809 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Didziokaite, Gabija
Biliute, Gabija
Gudaite, Jogaile
Kvedariene, Violeta
Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility
title Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility
title_full Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility
title_fullStr Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility
title_full_unstemmed Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility
title_short Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility
title_sort oxidative stress as a potential underlying cause of minimal and mild endometriosis-related infertility
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966009/
https://www.ncbi.nlm.nih.gov/pubmed/36835217
http://dx.doi.org/10.3390/ijms24043809
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