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Parkinson Symptom Severity and Use of Nutraceuticals

Background: It is estimated that half of the individuals with Parkinson’s disease (PD) use some form of over-the-counter vitamin, herbal supplement or nutraceutical. The goal of this study was to survey individuals with PD about their use of the nutraceuticals and evaluate the association of the nut...

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Autores principales: Mischley, Laurie K., Farahnik, Joshua, Mantay, Ludwig, Punzi, Jamie, Szampruch, Kayla, Ferguson, Tyrice, Fox, Devon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966010/
https://www.ncbi.nlm.nih.gov/pubmed/36839160
http://dx.doi.org/10.3390/nu15040802
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author Mischley, Laurie K.
Farahnik, Joshua
Mantay, Ludwig
Punzi, Jamie
Szampruch, Kayla
Ferguson, Tyrice
Fox, Devon J.
author_facet Mischley, Laurie K.
Farahnik, Joshua
Mantay, Ludwig
Punzi, Jamie
Szampruch, Kayla
Ferguson, Tyrice
Fox, Devon J.
author_sort Mischley, Laurie K.
collection PubMed
description Background: It is estimated that half of the individuals with Parkinson’s disease (PD) use some form of over-the-counter vitamin, herbal supplement or nutraceutical. The goal of this study was to survey individuals with PD about their use of the nutraceuticals and evaluate the association of the nutraceutical with the severity of symptoms. Methods: Participants with self-reported idiopathic PD within the 2021 cohort (n = 1084) were included in a cross-sectional study to assess association of nutraceuticals with symptom severity via linear regression analysis. PD severity was measured using the patient-reported outcomes in PD, and supplement use reflected self-reported consistent use over the previous six months. All regression analyses adjusted for age, gender, income and years since diagnosis. The use of the term progression refers to PRO-PD scores adjusted for years since diagnosis. Results: The most frequently used supplements were vitamin D (71%), B12 (44%), vitamin C (38%) and fish oil (38%). None of the supplements being used were associated with statistically significant worse outcomes. Nutraceuticals associated with improved outcomes were Ginkgo biloba (GB), NAD+ or its precursors, 5-methyltetrahydrofolate, glutathione, mucuna, CoQ10, low dose lithium, curcumin, homocysteine factors, DHEA, coconut oil, vitamin C, and omega-3 fatty acids (fish oil). Conclusions: These data suggest that in a real-world setting, some over-the-counter supplements are associated with fewer patient-reported symptoms. Supplements with significant associations with fewer symptoms have biological plausibility and future clinical trials should be explored.
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spelling pubmed-99660102023-02-26 Parkinson Symptom Severity and Use of Nutraceuticals Mischley, Laurie K. Farahnik, Joshua Mantay, Ludwig Punzi, Jamie Szampruch, Kayla Ferguson, Tyrice Fox, Devon J. Nutrients Communication Background: It is estimated that half of the individuals with Parkinson’s disease (PD) use some form of over-the-counter vitamin, herbal supplement or nutraceutical. The goal of this study was to survey individuals with PD about their use of the nutraceuticals and evaluate the association of the nutraceutical with the severity of symptoms. Methods: Participants with self-reported idiopathic PD within the 2021 cohort (n = 1084) were included in a cross-sectional study to assess association of nutraceuticals with symptom severity via linear regression analysis. PD severity was measured using the patient-reported outcomes in PD, and supplement use reflected self-reported consistent use over the previous six months. All regression analyses adjusted for age, gender, income and years since diagnosis. The use of the term progression refers to PRO-PD scores adjusted for years since diagnosis. Results: The most frequently used supplements were vitamin D (71%), B12 (44%), vitamin C (38%) and fish oil (38%). None of the supplements being used were associated with statistically significant worse outcomes. Nutraceuticals associated with improved outcomes were Ginkgo biloba (GB), NAD+ or its precursors, 5-methyltetrahydrofolate, glutathione, mucuna, CoQ10, low dose lithium, curcumin, homocysteine factors, DHEA, coconut oil, vitamin C, and omega-3 fatty acids (fish oil). Conclusions: These data suggest that in a real-world setting, some over-the-counter supplements are associated with fewer patient-reported symptoms. Supplements with significant associations with fewer symptoms have biological plausibility and future clinical trials should be explored. MDPI 2023-02-04 /pmc/articles/PMC9966010/ /pubmed/36839160 http://dx.doi.org/10.3390/nu15040802 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Mischley, Laurie K.
Farahnik, Joshua
Mantay, Ludwig
Punzi, Jamie
Szampruch, Kayla
Ferguson, Tyrice
Fox, Devon J.
Parkinson Symptom Severity and Use of Nutraceuticals
title Parkinson Symptom Severity and Use of Nutraceuticals
title_full Parkinson Symptom Severity and Use of Nutraceuticals
title_fullStr Parkinson Symptom Severity and Use of Nutraceuticals
title_full_unstemmed Parkinson Symptom Severity and Use of Nutraceuticals
title_short Parkinson Symptom Severity and Use of Nutraceuticals
title_sort parkinson symptom severity and use of nutraceuticals
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966010/
https://www.ncbi.nlm.nih.gov/pubmed/36839160
http://dx.doi.org/10.3390/nu15040802
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