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Obesity Induces an Impaired Placental Antiviral Immune Response in Pregnant Women Infected with Zika Virus

Obesity is increasing in incidence worldwide, especially in women, which can affect the outcome of pregnancy. During this period, viral infections represent a risk to the mother, the placental unit, and the fetus. The Zika virus (ZIKV) outbreak in Brazil has been the cause of congenital Zika syndrom...

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Autores principales: Branco, Anna Cláudia Calvielli Castelo, De Oliveira, Emily Araujo, Pereira, Nátalli Zanete, Alberca, Ricardo Wesley, Duarte-Neto, Amaro Nunes, Da Silva, Luiz Fernando Ferraz, Luiz, Fernanda Guedes, Pereira, Naiura Vieira, Sotto, Mirian Nacagami, Dejani, Naiara Naiana, Rondó, Patrícia Helen Carvalho, Avvad-Portari, Elyzabeth, De Vasconcelos, Zilton Farias Meira, Duarte, Alberto José da Silva, Azamor, Tamiris, Sato, Maria Notomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966111/
https://www.ncbi.nlm.nih.gov/pubmed/36851534
http://dx.doi.org/10.3390/v15020320
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author Branco, Anna Cláudia Calvielli Castelo
De Oliveira, Emily Araujo
Pereira, Nátalli Zanete
Alberca, Ricardo Wesley
Duarte-Neto, Amaro Nunes
Da Silva, Luiz Fernando Ferraz
Luiz, Fernanda Guedes
Pereira, Naiura Vieira
Sotto, Mirian Nacagami
Dejani, Naiara Naiana
Rondó, Patrícia Helen Carvalho
Avvad-Portari, Elyzabeth
De Vasconcelos, Zilton Farias Meira
Duarte, Alberto José da Silva
Azamor, Tamiris
Sato, Maria Notomi
author_facet Branco, Anna Cláudia Calvielli Castelo
De Oliveira, Emily Araujo
Pereira, Nátalli Zanete
Alberca, Ricardo Wesley
Duarte-Neto, Amaro Nunes
Da Silva, Luiz Fernando Ferraz
Luiz, Fernanda Guedes
Pereira, Naiura Vieira
Sotto, Mirian Nacagami
Dejani, Naiara Naiana
Rondó, Patrícia Helen Carvalho
Avvad-Portari, Elyzabeth
De Vasconcelos, Zilton Farias Meira
Duarte, Alberto José da Silva
Azamor, Tamiris
Sato, Maria Notomi
author_sort Branco, Anna Cláudia Calvielli Castelo
collection PubMed
description Obesity is increasing in incidence worldwide, especially in women, which can affect the outcome of pregnancy. During this period, viral infections represent a risk to the mother, the placental unit, and the fetus. The Zika virus (ZIKV) outbreak in Brazil has been the cause of congenital Zika syndrome (CZS), with devastating consequences such as microcephaly in newborns. Herein, we analyzed the impact of maternal overweight/obesity on the antiviral factors’ expression in the placental tissue of Zika-infected mothers. We accessed placentas from women with and without obesity from 34 public health units (São Paulo) and from Zika-infected mothers with and without obesity from the Clinical Cohort Study of ZIKV pregnant women (Rio de Janeiro, Brazil). We first verified that obesity, without infection, did not alter the constitutive transcriptional expression of antiviral factors or IFN type I/III expression. Interestingly, obesity, when associated with ZIKV infection, showed a decreased transcriptional expression of RIG-I and IFIH1 (MDA-5 protein precursor gene). At the protein level, we also verified a decreased RIG-I and IRF-3 expression in the decidual placenta from the Zika-infected obese group, regardless of microcephaly. This finding shows, for the first time, that obesity associated with ZIKV infection leads to an impaired type I IFN downstream signaling pathway in the maternal–fetal interface.
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spelling pubmed-99661112023-02-26 Obesity Induces an Impaired Placental Antiviral Immune Response in Pregnant Women Infected with Zika Virus Branco, Anna Cláudia Calvielli Castelo De Oliveira, Emily Araujo Pereira, Nátalli Zanete Alberca, Ricardo Wesley Duarte-Neto, Amaro Nunes Da Silva, Luiz Fernando Ferraz Luiz, Fernanda Guedes Pereira, Naiura Vieira Sotto, Mirian Nacagami Dejani, Naiara Naiana Rondó, Patrícia Helen Carvalho Avvad-Portari, Elyzabeth De Vasconcelos, Zilton Farias Meira Duarte, Alberto José da Silva Azamor, Tamiris Sato, Maria Notomi Viruses Article Obesity is increasing in incidence worldwide, especially in women, which can affect the outcome of pregnancy. During this period, viral infections represent a risk to the mother, the placental unit, and the fetus. The Zika virus (ZIKV) outbreak in Brazil has been the cause of congenital Zika syndrome (CZS), with devastating consequences such as microcephaly in newborns. Herein, we analyzed the impact of maternal overweight/obesity on the antiviral factors’ expression in the placental tissue of Zika-infected mothers. We accessed placentas from women with and without obesity from 34 public health units (São Paulo) and from Zika-infected mothers with and without obesity from the Clinical Cohort Study of ZIKV pregnant women (Rio de Janeiro, Brazil). We first verified that obesity, without infection, did not alter the constitutive transcriptional expression of antiviral factors or IFN type I/III expression. Interestingly, obesity, when associated with ZIKV infection, showed a decreased transcriptional expression of RIG-I and IFIH1 (MDA-5 protein precursor gene). At the protein level, we also verified a decreased RIG-I and IRF-3 expression in the decidual placenta from the Zika-infected obese group, regardless of microcephaly. This finding shows, for the first time, that obesity associated with ZIKV infection leads to an impaired type I IFN downstream signaling pathway in the maternal–fetal interface. MDPI 2023-01-23 /pmc/articles/PMC9966111/ /pubmed/36851534 http://dx.doi.org/10.3390/v15020320 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Branco, Anna Cláudia Calvielli Castelo
De Oliveira, Emily Araujo
Pereira, Nátalli Zanete
Alberca, Ricardo Wesley
Duarte-Neto, Amaro Nunes
Da Silva, Luiz Fernando Ferraz
Luiz, Fernanda Guedes
Pereira, Naiura Vieira
Sotto, Mirian Nacagami
Dejani, Naiara Naiana
Rondó, Patrícia Helen Carvalho
Avvad-Portari, Elyzabeth
De Vasconcelos, Zilton Farias Meira
Duarte, Alberto José da Silva
Azamor, Tamiris
Sato, Maria Notomi
Obesity Induces an Impaired Placental Antiviral Immune Response in Pregnant Women Infected with Zika Virus
title Obesity Induces an Impaired Placental Antiviral Immune Response in Pregnant Women Infected with Zika Virus
title_full Obesity Induces an Impaired Placental Antiviral Immune Response in Pregnant Women Infected with Zika Virus
title_fullStr Obesity Induces an Impaired Placental Antiviral Immune Response in Pregnant Women Infected with Zika Virus
title_full_unstemmed Obesity Induces an Impaired Placental Antiviral Immune Response in Pregnant Women Infected with Zika Virus
title_short Obesity Induces an Impaired Placental Antiviral Immune Response in Pregnant Women Infected with Zika Virus
title_sort obesity induces an impaired placental antiviral immune response in pregnant women infected with zika virus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966111/
https://www.ncbi.nlm.nih.gov/pubmed/36851534
http://dx.doi.org/10.3390/v15020320
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