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Antifungal and Antibacterial Activities of Isolated Marine Compounds

To combat the ineffectiveness of currently available pharmaceutical medications, caused by the emergence of increasingly resistant bacterial and fungal strains, novel antibacterial and antifungal medications are urgently needed. Novel natural compounds with antimicrobial activities can be obtained b...

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Autores principales: Thawabteh, Amin Mahmood, Swaileh, Zain, Ammar, Marwa, Jaghama, Weam, Yousef, Mai, Karaman, Rafik, A. Bufo, Sabino, Scrano, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966175/
https://www.ncbi.nlm.nih.gov/pubmed/36828408
http://dx.doi.org/10.3390/toxins15020093
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author Thawabteh, Amin Mahmood
Swaileh, Zain
Ammar, Marwa
Jaghama, Weam
Yousef, Mai
Karaman, Rafik
A. Bufo, Sabino
Scrano, Laura
author_facet Thawabteh, Amin Mahmood
Swaileh, Zain
Ammar, Marwa
Jaghama, Weam
Yousef, Mai
Karaman, Rafik
A. Bufo, Sabino
Scrano, Laura
author_sort Thawabteh, Amin Mahmood
collection PubMed
description To combat the ineffectiveness of currently available pharmaceutical medications, caused by the emergence of increasingly resistant bacterial and fungal strains, novel antibacterial and antifungal medications are urgently needed. Novel natural compounds with antimicrobial activities can be obtained by exploring underexplored habitats such as the world’s oceans. The oceans represent the largest ecosystem on earth, with a high diversity of organisms. Oceans have received some attention in the past few years, and promising compounds with antimicrobial activities were isolated from marine organisms such as bacteria, fungi, algae, sea cucumbers, sea sponges, etc. This review covers 56 antifungal and 40 antibacterial compounds from marine organisms. These compounds are categorized according to their chemical structure groups, including polyketides, alkaloids, ribosomal peptides, and terpenes, and their organismal origin. The review provides the minimum inhibitory concentration MIC values and the bacterial/fungal strains against which these chemical compounds show activity. This study shows strong potential for witnessing the development of new novel antimicrobial drugs from these natural compounds isolated and evaluated for their antimicrobial activities.
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spelling pubmed-99661752023-02-26 Antifungal and Antibacterial Activities of Isolated Marine Compounds Thawabteh, Amin Mahmood Swaileh, Zain Ammar, Marwa Jaghama, Weam Yousef, Mai Karaman, Rafik A. Bufo, Sabino Scrano, Laura Toxins (Basel) Review To combat the ineffectiveness of currently available pharmaceutical medications, caused by the emergence of increasingly resistant bacterial and fungal strains, novel antibacterial and antifungal medications are urgently needed. Novel natural compounds with antimicrobial activities can be obtained by exploring underexplored habitats such as the world’s oceans. The oceans represent the largest ecosystem on earth, with a high diversity of organisms. Oceans have received some attention in the past few years, and promising compounds with antimicrobial activities were isolated from marine organisms such as bacteria, fungi, algae, sea cucumbers, sea sponges, etc. This review covers 56 antifungal and 40 antibacterial compounds from marine organisms. These compounds are categorized according to their chemical structure groups, including polyketides, alkaloids, ribosomal peptides, and terpenes, and their organismal origin. The review provides the minimum inhibitory concentration MIC values and the bacterial/fungal strains against which these chemical compounds show activity. This study shows strong potential for witnessing the development of new novel antimicrobial drugs from these natural compounds isolated and evaluated for their antimicrobial activities. MDPI 2023-01-18 /pmc/articles/PMC9966175/ /pubmed/36828408 http://dx.doi.org/10.3390/toxins15020093 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Thawabteh, Amin Mahmood
Swaileh, Zain
Ammar, Marwa
Jaghama, Weam
Yousef, Mai
Karaman, Rafik
A. Bufo, Sabino
Scrano, Laura
Antifungal and Antibacterial Activities of Isolated Marine Compounds
title Antifungal and Antibacterial Activities of Isolated Marine Compounds
title_full Antifungal and Antibacterial Activities of Isolated Marine Compounds
title_fullStr Antifungal and Antibacterial Activities of Isolated Marine Compounds
title_full_unstemmed Antifungal and Antibacterial Activities of Isolated Marine Compounds
title_short Antifungal and Antibacterial Activities of Isolated Marine Compounds
title_sort antifungal and antibacterial activities of isolated marine compounds
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966175/
https://www.ncbi.nlm.nih.gov/pubmed/36828408
http://dx.doi.org/10.3390/toxins15020093
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