A Lewis Acid-Promoted Michael Addition and Ring-Expansion Cascade for the Construction of Nitrogen-Containing Medium-Sized Rings

A Lewis acid-promoted annulation of azadienes and cyclobutamines was developed. This reaction proceeded through Michael addition and ring-expansion cascade, affording the corresponding nitrogen-containing medium-sized rings with a broad scope in moderate to high yields. The catalytic asymmetric vers...

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Detalles Bibliográficos
Autores principales: Wang, Jiaming, Li, Jia, Zhao, Changgui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966210/
https://www.ncbi.nlm.nih.gov/pubmed/36838638
http://dx.doi.org/10.3390/molecules28041650
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author Wang, Jiaming
Li, Jia
Zhao, Changgui
author_facet Wang, Jiaming
Li, Jia
Zhao, Changgui
author_sort Wang, Jiaming
collection PubMed
description A Lewis acid-promoted annulation of azadienes and cyclobutamines was developed. This reaction proceeded through Michael addition and ring-expansion cascade, affording the corresponding nitrogen-containing medium-sized rings with a broad scope in moderate to high yields. The catalytic asymmetric version of this reaction has also been explored using a chiral base.
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spelling pubmed-99662102023-02-26 A Lewis Acid-Promoted Michael Addition and Ring-Expansion Cascade for the Construction of Nitrogen-Containing Medium-Sized Rings Wang, Jiaming Li, Jia Zhao, Changgui Molecules Article A Lewis acid-promoted annulation of azadienes and cyclobutamines was developed. This reaction proceeded through Michael addition and ring-expansion cascade, affording the corresponding nitrogen-containing medium-sized rings with a broad scope in moderate to high yields. The catalytic asymmetric version of this reaction has also been explored using a chiral base. MDPI 2023-02-08 /pmc/articles/PMC9966210/ /pubmed/36838638 http://dx.doi.org/10.3390/molecules28041650 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Jiaming
Li, Jia
Zhao, Changgui
A Lewis Acid-Promoted Michael Addition and Ring-Expansion Cascade for the Construction of Nitrogen-Containing Medium-Sized Rings
title A Lewis Acid-Promoted Michael Addition and Ring-Expansion Cascade for the Construction of Nitrogen-Containing Medium-Sized Rings
title_full A Lewis Acid-Promoted Michael Addition and Ring-Expansion Cascade for the Construction of Nitrogen-Containing Medium-Sized Rings
title_fullStr A Lewis Acid-Promoted Michael Addition and Ring-Expansion Cascade for the Construction of Nitrogen-Containing Medium-Sized Rings
title_full_unstemmed A Lewis Acid-Promoted Michael Addition and Ring-Expansion Cascade for the Construction of Nitrogen-Containing Medium-Sized Rings
title_short A Lewis Acid-Promoted Michael Addition and Ring-Expansion Cascade for the Construction of Nitrogen-Containing Medium-Sized Rings
title_sort lewis acid-promoted michael addition and ring-expansion cascade for the construction of nitrogen-containing medium-sized rings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966210/
https://www.ncbi.nlm.nih.gov/pubmed/36838638
http://dx.doi.org/10.3390/molecules28041650
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