BET Bromodomain Degradation Disrupts Function but Not 3D Formation of RNA Pol2 Clusters

Fusion-positive rhabdomyosarcoma (FP-RMS) is driven by a translocation that creates the chimeric transcription factor PAX3-FOXO1 (P3F), which assembles de novo super enhancers to drive high levels of transcription of other core regulatory transcription factors (CRTFs). P3F recruits co-regulatory fac...

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Detalles Bibliográficos
Autores principales: Chin, Diana H., Osman, Issra, Porch, Jadon, Kim, Hyunmin, Buck, Kristen K., Rodriguez, Javier, Carapia, Bianca, Yan, Deborah, Moura, Stela B., Sperry, Jantzen, Nakashima, Jonathan, Altman, Kasey, Altman, Delsee, Gryder, Berkley E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966215/
https://www.ncbi.nlm.nih.gov/pubmed/37259348
http://dx.doi.org/10.3390/ph16020199

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