Unraveling the Diverse Roles of Neglected Genes Containing Domains of Unknown Function (DUFs): Progress and Perspective

Domain of unknown function (DUF) is a general term for many uncharacterized domains with two distinct features: relatively conservative amino acid sequence and unknown function of the domain. In the Pfam 35.0 database, 4795 (24%) gene families belong to the DUF type, yet, their functions remain to b...

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Detalles Bibliográficos
Autores principales: Lv, Peiyun, Wan, Jinlu, Zhang, Chunting, Hina, Aiman, Al Amin, G M, Begum, Naheeda, Zhao, Tuanjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966272/
https://www.ncbi.nlm.nih.gov/pubmed/36835600
http://dx.doi.org/10.3390/ijms24044187
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author Lv, Peiyun
Wan, Jinlu
Zhang, Chunting
Hina, Aiman
Al Amin, G M
Begum, Naheeda
Zhao, Tuanjie
author_facet Lv, Peiyun
Wan, Jinlu
Zhang, Chunting
Hina, Aiman
Al Amin, G M
Begum, Naheeda
Zhao, Tuanjie
author_sort Lv, Peiyun
collection PubMed
description Domain of unknown function (DUF) is a general term for many uncharacterized domains with two distinct features: relatively conservative amino acid sequence and unknown function of the domain. In the Pfam 35.0 database, 4795 (24%) gene families belong to the DUF type, yet, their functions remain to be explored. This review summarizes the characteristics of the DUF protein families and their functions in regulating plant growth and development, generating responses to biotic and abiotic stress, and other regulatory roles in plant life. Though very limited information is available about these proteins yet, by taking advantage of emerging omics and bioinformatic tools, functional studies of DUF proteins could be utilized in future molecular studies.
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spelling pubmed-99662722023-02-26 Unraveling the Diverse Roles of Neglected Genes Containing Domains of Unknown Function (DUFs): Progress and Perspective Lv, Peiyun Wan, Jinlu Zhang, Chunting Hina, Aiman Al Amin, G M Begum, Naheeda Zhao, Tuanjie Int J Mol Sci Review Domain of unknown function (DUF) is a general term for many uncharacterized domains with two distinct features: relatively conservative amino acid sequence and unknown function of the domain. In the Pfam 35.0 database, 4795 (24%) gene families belong to the DUF type, yet, their functions remain to be explored. This review summarizes the characteristics of the DUF protein families and their functions in regulating plant growth and development, generating responses to biotic and abiotic stress, and other regulatory roles in plant life. Though very limited information is available about these proteins yet, by taking advantage of emerging omics and bioinformatic tools, functional studies of DUF proteins could be utilized in future molecular studies. MDPI 2023-02-20 /pmc/articles/PMC9966272/ /pubmed/36835600 http://dx.doi.org/10.3390/ijms24044187 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lv, Peiyun
Wan, Jinlu
Zhang, Chunting
Hina, Aiman
Al Amin, G M
Begum, Naheeda
Zhao, Tuanjie
Unraveling the Diverse Roles of Neglected Genes Containing Domains of Unknown Function (DUFs): Progress and Perspective
title Unraveling the Diverse Roles of Neglected Genes Containing Domains of Unknown Function (DUFs): Progress and Perspective
title_full Unraveling the Diverse Roles of Neglected Genes Containing Domains of Unknown Function (DUFs): Progress and Perspective
title_fullStr Unraveling the Diverse Roles of Neglected Genes Containing Domains of Unknown Function (DUFs): Progress and Perspective
title_full_unstemmed Unraveling the Diverse Roles of Neglected Genes Containing Domains of Unknown Function (DUFs): Progress and Perspective
title_short Unraveling the Diverse Roles of Neglected Genes Containing Domains of Unknown Function (DUFs): Progress and Perspective
title_sort unraveling the diverse roles of neglected genes containing domains of unknown function (dufs): progress and perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966272/
https://www.ncbi.nlm.nih.gov/pubmed/36835600
http://dx.doi.org/10.3390/ijms24044187
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