Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4-d]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme

The therapeutic use of tyrosine kinase inhibitors (TKIs) represents one of the successful strategies for the treatment of glioblastoma (GBM). Pyrazolo[3,4-d]pyrimidines have already been reported as promising small molecules active as c-Src/Abl dual inhibitors. Herein, we present a series of pyrazol...

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Detalles Bibliográficos
Autores principales: Poggialini, Federica, Vagaggini, Chiara, Brai, Annalaura, Pasqualini, Claudia, Crespan, Emmanuele, Maga, Giovanni, Perini, Cecilia, Cabella, Noemi, Botta, Lorenzo, Musumeci, Francesca, Frosini, Maria, Schenone, Silvia, Dreassi, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966370/
https://www.ncbi.nlm.nih.gov/pubmed/36839775
http://dx.doi.org/10.3390/pharmaceutics15020453

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