Cargando…

Matrix Metalloproteinases in Chronic Obstructive Pulmonary Disease

Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade proteins of the extracellular matrix and the basement membrane. Thus, these enzymes regulate airway remodeling, which is a major pathological feature of chronic obstructive pulmonary disease (COPD). Furthermore, proteolytic destru...

Descripción completa

Detalles Bibliográficos
Autores principales: Christopoulou, Maria-Elpida, Papakonstantinou, Eleni, Stolz, Daiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966421/
https://www.ncbi.nlm.nih.gov/pubmed/36835197
http://dx.doi.org/10.3390/ijms24043786
_version_ 1784897012756381696
author Christopoulou, Maria-Elpida
Papakonstantinou, Eleni
Stolz, Daiana
author_facet Christopoulou, Maria-Elpida
Papakonstantinou, Eleni
Stolz, Daiana
author_sort Christopoulou, Maria-Elpida
collection PubMed
description Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade proteins of the extracellular matrix and the basement membrane. Thus, these enzymes regulate airway remodeling, which is a major pathological feature of chronic obstructive pulmonary disease (COPD). Furthermore, proteolytic destruction in the lungs may lead to loss of elastin and the development of emphysema, which is associated with poor lung function in COPD patients. In this literature review, we describe and appraise evidence from the recent literature regarding the role of different MMPs in COPD, as well as how their activity is regulated by specific tissue inhibitors. Considering the importance of MMPs in COPD pathogenesis, we also discuss MMPs as potential targets for therapeutic intervention in COPD and present evidence from recent clinical trials in this regard.
format Online
Article
Text
id pubmed-9966421
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99664212023-02-26 Matrix Metalloproteinases in Chronic Obstructive Pulmonary Disease Christopoulou, Maria-Elpida Papakonstantinou, Eleni Stolz, Daiana Int J Mol Sci Review Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade proteins of the extracellular matrix and the basement membrane. Thus, these enzymes regulate airway remodeling, which is a major pathological feature of chronic obstructive pulmonary disease (COPD). Furthermore, proteolytic destruction in the lungs may lead to loss of elastin and the development of emphysema, which is associated with poor lung function in COPD patients. In this literature review, we describe and appraise evidence from the recent literature regarding the role of different MMPs in COPD, as well as how their activity is regulated by specific tissue inhibitors. Considering the importance of MMPs in COPD pathogenesis, we also discuss MMPs as potential targets for therapeutic intervention in COPD and present evidence from recent clinical trials in this regard. MDPI 2023-02-14 /pmc/articles/PMC9966421/ /pubmed/36835197 http://dx.doi.org/10.3390/ijms24043786 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Christopoulou, Maria-Elpida
Papakonstantinou, Eleni
Stolz, Daiana
Matrix Metalloproteinases in Chronic Obstructive Pulmonary Disease
title Matrix Metalloproteinases in Chronic Obstructive Pulmonary Disease
title_full Matrix Metalloproteinases in Chronic Obstructive Pulmonary Disease
title_fullStr Matrix Metalloproteinases in Chronic Obstructive Pulmonary Disease
title_full_unstemmed Matrix Metalloproteinases in Chronic Obstructive Pulmonary Disease
title_short Matrix Metalloproteinases in Chronic Obstructive Pulmonary Disease
title_sort matrix metalloproteinases in chronic obstructive pulmonary disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966421/
https://www.ncbi.nlm.nih.gov/pubmed/36835197
http://dx.doi.org/10.3390/ijms24043786
work_keys_str_mv AT christopouloumariaelpida matrixmetalloproteinasesinchronicobstructivepulmonarydisease
AT papakonstantinoueleni matrixmetalloproteinasesinchronicobstructivepulmonarydisease
AT stolzdaiana matrixmetalloproteinasesinchronicobstructivepulmonarydisease