Papillomavirus-like Particles in Equine Medicine

Papillomaviruses (PVs) are a family of small DNA tumor viruses that can induce benign lesions or cancer in vertebrates. The observation that animal PV capsid-proteins spontaneously self-assemble to empty, highly immunogenic virus-like particles (VLPs) has led to the establishment of vaccines that ef...

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Autores principales: Hainisch, Edmund K., Jindra, Christoph, Kirnbauer, Reinhard, Brandt, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966523/
https://www.ncbi.nlm.nih.gov/pubmed/36851559
http://dx.doi.org/10.3390/v15020345
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author Hainisch, Edmund K.
Jindra, Christoph
Kirnbauer, Reinhard
Brandt, Sabine
author_facet Hainisch, Edmund K.
Jindra, Christoph
Kirnbauer, Reinhard
Brandt, Sabine
author_sort Hainisch, Edmund K.
collection PubMed
description Papillomaviruses (PVs) are a family of small DNA tumor viruses that can induce benign lesions or cancer in vertebrates. The observation that animal PV capsid-proteins spontaneously self-assemble to empty, highly immunogenic virus-like particles (VLPs) has led to the establishment of vaccines that efficiently protect humans from specific PV infections and associated diseases. We provide an overview of PV-induced tumors in horses and other equids, discuss possible routes of PV transmission in equid species, and present recent developments aiming at introducing the PV VLP-based vaccine technology into equine medicine.
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spelling pubmed-99665232023-02-26 Papillomavirus-like Particles in Equine Medicine Hainisch, Edmund K. Jindra, Christoph Kirnbauer, Reinhard Brandt, Sabine Viruses Review Papillomaviruses (PVs) are a family of small DNA tumor viruses that can induce benign lesions or cancer in vertebrates. The observation that animal PV capsid-proteins spontaneously self-assemble to empty, highly immunogenic virus-like particles (VLPs) has led to the establishment of vaccines that efficiently protect humans from specific PV infections and associated diseases. We provide an overview of PV-induced tumors in horses and other equids, discuss possible routes of PV transmission in equid species, and present recent developments aiming at introducing the PV VLP-based vaccine technology into equine medicine. MDPI 2023-01-25 /pmc/articles/PMC9966523/ /pubmed/36851559 http://dx.doi.org/10.3390/v15020345 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hainisch, Edmund K.
Jindra, Christoph
Kirnbauer, Reinhard
Brandt, Sabine
Papillomavirus-like Particles in Equine Medicine
title Papillomavirus-like Particles in Equine Medicine
title_full Papillomavirus-like Particles in Equine Medicine
title_fullStr Papillomavirus-like Particles in Equine Medicine
title_full_unstemmed Papillomavirus-like Particles in Equine Medicine
title_short Papillomavirus-like Particles in Equine Medicine
title_sort papillomavirus-like particles in equine medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966523/
https://www.ncbi.nlm.nih.gov/pubmed/36851559
http://dx.doi.org/10.3390/v15020345
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AT jindrachristoph papillomaviruslikeparticlesinequinemedicine
AT kirnbauerreinhard papillomaviruslikeparticlesinequinemedicine
AT brandtsabine papillomaviruslikeparticlesinequinemedicine

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