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Mesenchymal Stromal Cell-Based Targeted Therapy Pancreatic Cancer: Progress and Challenges
Pancreatic cancer is an aggressive malignancy with high mortality rates and poor prognoses. Despite rapid progress in the diagnosis and treatment of pancreatic cancer, the efficacy of current therapeutic strategies remains limited. Hence, better alternative therapeutic options for treating pancreati...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966548/ https://www.ncbi.nlm.nih.gov/pubmed/36834969 http://dx.doi.org/10.3390/ijms24043559 |
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author | Ma, Zhilong Hua, Jie Liu, Jiang Zhang, Bo Wang, Wei Yu, Xianjun Xu, Jin |
author_facet | Ma, Zhilong Hua, Jie Liu, Jiang Zhang, Bo Wang, Wei Yu, Xianjun Xu, Jin |
author_sort | Ma, Zhilong |
collection | PubMed |
description | Pancreatic cancer is an aggressive malignancy with high mortality rates and poor prognoses. Despite rapid progress in the diagnosis and treatment of pancreatic cancer, the efficacy of current therapeutic strategies remains limited. Hence, better alternative therapeutic options for treating pancreatic cancer need to be urgently explored. Mesenchymal stromal cells (MSCs) have recently received much attention as a potential therapy for pancreatic cancer owing to their tumor-homing properties. However, the specific antitumor effect of MSCs is still controversial. To this end, we aimed to focus on the potential anti-cancer treatment prospects of the MSC-based approach and summarize current challenges in the clinical application of MSCs to treat pancreatic cancer. |
format | Online Article Text |
id | pubmed-9966548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99665482023-02-26 Mesenchymal Stromal Cell-Based Targeted Therapy Pancreatic Cancer: Progress and Challenges Ma, Zhilong Hua, Jie Liu, Jiang Zhang, Bo Wang, Wei Yu, Xianjun Xu, Jin Int J Mol Sci Review Pancreatic cancer is an aggressive malignancy with high mortality rates and poor prognoses. Despite rapid progress in the diagnosis and treatment of pancreatic cancer, the efficacy of current therapeutic strategies remains limited. Hence, better alternative therapeutic options for treating pancreatic cancer need to be urgently explored. Mesenchymal stromal cells (MSCs) have recently received much attention as a potential therapy for pancreatic cancer owing to their tumor-homing properties. However, the specific antitumor effect of MSCs is still controversial. To this end, we aimed to focus on the potential anti-cancer treatment prospects of the MSC-based approach and summarize current challenges in the clinical application of MSCs to treat pancreatic cancer. MDPI 2023-02-10 /pmc/articles/PMC9966548/ /pubmed/36834969 http://dx.doi.org/10.3390/ijms24043559 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ma, Zhilong Hua, Jie Liu, Jiang Zhang, Bo Wang, Wei Yu, Xianjun Xu, Jin Mesenchymal Stromal Cell-Based Targeted Therapy Pancreatic Cancer: Progress and Challenges |
title | Mesenchymal Stromal Cell-Based Targeted Therapy Pancreatic Cancer: Progress and Challenges |
title_full | Mesenchymal Stromal Cell-Based Targeted Therapy Pancreatic Cancer: Progress and Challenges |
title_fullStr | Mesenchymal Stromal Cell-Based Targeted Therapy Pancreatic Cancer: Progress and Challenges |
title_full_unstemmed | Mesenchymal Stromal Cell-Based Targeted Therapy Pancreatic Cancer: Progress and Challenges |
title_short | Mesenchymal Stromal Cell-Based Targeted Therapy Pancreatic Cancer: Progress and Challenges |
title_sort | mesenchymal stromal cell-based targeted therapy pancreatic cancer: progress and challenges |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966548/ https://www.ncbi.nlm.nih.gov/pubmed/36834969 http://dx.doi.org/10.3390/ijms24043559 |
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