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Clinical Presentation and Risk Factors of Infective Endocarditis in the Elderly: A Systematic Review
Infective endocarditis (IE) is a bacterial infection with high morbidity and mortality rates, particularly among the elderly. This systematic review was conducted to determine the clinical characteristics of IE in older adults and the risk factors that could lead to adverse outcomes. The research em...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966560/ https://www.ncbi.nlm.nih.gov/pubmed/36836530 http://dx.doi.org/10.3390/jpm13020296 |
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author | Budea, Camelia Melania Bratosin, Felix Bogdan, Iulia Bota, Adrian Vasile Turaiche, Mirela Tirnea, Livius Stoica, Carmen Nicoleta Csep, Andrei Nicolae Feciche, Bogdan Pescariu, Silvius Alexandru Popa, Malina Mavrea, Adelina Bumbu, Bogdan Andrei Bandi, Satya Sai Sri Marincu, Iosif |
author_facet | Budea, Camelia Melania Bratosin, Felix Bogdan, Iulia Bota, Adrian Vasile Turaiche, Mirela Tirnea, Livius Stoica, Carmen Nicoleta Csep, Andrei Nicolae Feciche, Bogdan Pescariu, Silvius Alexandru Popa, Malina Mavrea, Adelina Bumbu, Bogdan Andrei Bandi, Satya Sai Sri Marincu, Iosif |
author_sort | Budea, Camelia Melania |
collection | PubMed |
description | Infective endocarditis (IE) is a bacterial infection with high morbidity and mortality rates, particularly among the elderly. This systematic review was conducted to determine the clinical characteristics of IE in older adults and the risk factors that could lead to adverse outcomes. The research employed three databases (PubMed, Wiley, and Web of Science), with a primary search for studies that have described cases of IE in patients older than 65 years. From a total of 555 articles, 10 were selected for inclusion in the current study, comprising a total of 2222 patients with a confirmed diagnosis of IE. The primary findings were an increased incidence of staphylococcal and streptococcal infections (33.4% and32.0%, respectively), an increased prevalence of comorbidities, namely, cardiovascular disease, diabetes, and cancer, and a significantly greater mortality risk than the younger group. Regarding mortality risks, the pooled odds ratio for cardiac disorders was OR = 3.81, septic shock OR = 8.22, renal complications OR = 3.75, and advancing age OR = 3.54 were most frequently mentioned. Taking into consideration the fact that the majority of the elderly population suffers from significant complications and is unable to undergo surgery due to an increased risk of complications after the procedure, it is imperative that effective treatment methods should be investigated. |
format | Online Article Text |
id | pubmed-9966560 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99665602023-02-26 Clinical Presentation and Risk Factors of Infective Endocarditis in the Elderly: A Systematic Review Budea, Camelia Melania Bratosin, Felix Bogdan, Iulia Bota, Adrian Vasile Turaiche, Mirela Tirnea, Livius Stoica, Carmen Nicoleta Csep, Andrei Nicolae Feciche, Bogdan Pescariu, Silvius Alexandru Popa, Malina Mavrea, Adelina Bumbu, Bogdan Andrei Bandi, Satya Sai Sri Marincu, Iosif J Pers Med Systematic Review Infective endocarditis (IE) is a bacterial infection with high morbidity and mortality rates, particularly among the elderly. This systematic review was conducted to determine the clinical characteristics of IE in older adults and the risk factors that could lead to adverse outcomes. The research employed three databases (PubMed, Wiley, and Web of Science), with a primary search for studies that have described cases of IE in patients older than 65 years. From a total of 555 articles, 10 were selected for inclusion in the current study, comprising a total of 2222 patients with a confirmed diagnosis of IE. The primary findings were an increased incidence of staphylococcal and streptococcal infections (33.4% and32.0%, respectively), an increased prevalence of comorbidities, namely, cardiovascular disease, diabetes, and cancer, and a significantly greater mortality risk than the younger group. Regarding mortality risks, the pooled odds ratio for cardiac disorders was OR = 3.81, septic shock OR = 8.22, renal complications OR = 3.75, and advancing age OR = 3.54 were most frequently mentioned. Taking into consideration the fact that the majority of the elderly population suffers from significant complications and is unable to undergo surgery due to an increased risk of complications after the procedure, it is imperative that effective treatment methods should be investigated. MDPI 2023-02-07 /pmc/articles/PMC9966560/ /pubmed/36836530 http://dx.doi.org/10.3390/jpm13020296 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Budea, Camelia Melania Bratosin, Felix Bogdan, Iulia Bota, Adrian Vasile Turaiche, Mirela Tirnea, Livius Stoica, Carmen Nicoleta Csep, Andrei Nicolae Feciche, Bogdan Pescariu, Silvius Alexandru Popa, Malina Mavrea, Adelina Bumbu, Bogdan Andrei Bandi, Satya Sai Sri Marincu, Iosif Clinical Presentation and Risk Factors of Infective Endocarditis in the Elderly: A Systematic Review |
title | Clinical Presentation and Risk Factors of Infective Endocarditis in the Elderly: A Systematic Review |
title_full | Clinical Presentation and Risk Factors of Infective Endocarditis in the Elderly: A Systematic Review |
title_fullStr | Clinical Presentation and Risk Factors of Infective Endocarditis in the Elderly: A Systematic Review |
title_full_unstemmed | Clinical Presentation and Risk Factors of Infective Endocarditis in the Elderly: A Systematic Review |
title_short | Clinical Presentation and Risk Factors of Infective Endocarditis in the Elderly: A Systematic Review |
title_sort | clinical presentation and risk factors of infective endocarditis in the elderly: a systematic review |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966560/ https://www.ncbi.nlm.nih.gov/pubmed/36836530 http://dx.doi.org/10.3390/jpm13020296 |
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