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Self-Reported Assessment of the Socio-Economic Impact of Anticancer Chemotherapy-Related Neurotoxicity

Chemotherapy-induced neurotoxicity is a well-known complication of several very effective systemic anticancer treatments, mainly presenting as cognitive impairment (“chemo-brain”) and peripheral neuropathy. The social and economic effects of long-lasting chemotherapy-induced neurotoxicity on patient...

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Autores principales: Cavaletti, Guido, D’Acunti, Alessia, Porcu, Alessandro, Masiello, Gabriella, Del Campo, Laura, Traclò, Gianfranca, De Lorenzo, Francesco, Bernasconi, Davide Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966709/
https://www.ncbi.nlm.nih.gov/pubmed/36850979
http://dx.doi.org/10.3390/toxics11020104
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author Cavaletti, Guido
D’Acunti, Alessia
Porcu, Alessandro
Masiello, Gabriella
Del Campo, Laura
Traclò, Gianfranca
De Lorenzo, Francesco
Bernasconi, Davide Paolo
author_facet Cavaletti, Guido
D’Acunti, Alessia
Porcu, Alessandro
Masiello, Gabriella
Del Campo, Laura
Traclò, Gianfranca
De Lorenzo, Francesco
Bernasconi, Davide Paolo
author_sort Cavaletti, Guido
collection PubMed
description Chemotherapy-induced neurotoxicity is a well-known complication of several very effective systemic anticancer treatments, mainly presenting as cognitive impairment (“chemo-brain”) and peripheral neuropathy. The social and economic effects of long-lasting chemotherapy-induced neurotoxicity on patients’ lifestyles and their relationships are under-investigated, and their impact is, therefore, largely unknown. In this study, we used a web-based questionnaire to record the self-reported perception of chemotherapy-induced neurotoxicity on cancer patients’ health status, but also on several different aspects of their daily life. From the study results, it emerged that the impact of chemotherapy-induced neurotoxicity on personal, social, and working activities is very high. A similar effect was also observed when the psychological impact is assessed. Moreover, there is evidence suggesting that the management of CIPN is suboptimal; this is partially due to a lack of effective drugs, but also of appropriate advice from healthcare providers. In conclusion, this study provides evidence for the relevance of the impact on the explored aspects of the daily life of cancer patients and spotlights the need for a larger and more structured investigation on these long-term side effects of anticancer chemotherapy.
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spelling pubmed-99667092023-02-26 Self-Reported Assessment of the Socio-Economic Impact of Anticancer Chemotherapy-Related Neurotoxicity Cavaletti, Guido D’Acunti, Alessia Porcu, Alessandro Masiello, Gabriella Del Campo, Laura Traclò, Gianfranca De Lorenzo, Francesco Bernasconi, Davide Paolo Toxics Case Report Chemotherapy-induced neurotoxicity is a well-known complication of several very effective systemic anticancer treatments, mainly presenting as cognitive impairment (“chemo-brain”) and peripheral neuropathy. The social and economic effects of long-lasting chemotherapy-induced neurotoxicity on patients’ lifestyles and their relationships are under-investigated, and their impact is, therefore, largely unknown. In this study, we used a web-based questionnaire to record the self-reported perception of chemotherapy-induced neurotoxicity on cancer patients’ health status, but also on several different aspects of their daily life. From the study results, it emerged that the impact of chemotherapy-induced neurotoxicity on personal, social, and working activities is very high. A similar effect was also observed when the psychological impact is assessed. Moreover, there is evidence suggesting that the management of CIPN is suboptimal; this is partially due to a lack of effective drugs, but also of appropriate advice from healthcare providers. In conclusion, this study provides evidence for the relevance of the impact on the explored aspects of the daily life of cancer patients and spotlights the need for a larger and more structured investigation on these long-term side effects of anticancer chemotherapy. MDPI 2023-01-22 /pmc/articles/PMC9966709/ /pubmed/36850979 http://dx.doi.org/10.3390/toxics11020104 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Cavaletti, Guido
D’Acunti, Alessia
Porcu, Alessandro
Masiello, Gabriella
Del Campo, Laura
Traclò, Gianfranca
De Lorenzo, Francesco
Bernasconi, Davide Paolo
Self-Reported Assessment of the Socio-Economic Impact of Anticancer Chemotherapy-Related Neurotoxicity
title Self-Reported Assessment of the Socio-Economic Impact of Anticancer Chemotherapy-Related Neurotoxicity
title_full Self-Reported Assessment of the Socio-Economic Impact of Anticancer Chemotherapy-Related Neurotoxicity
title_fullStr Self-Reported Assessment of the Socio-Economic Impact of Anticancer Chemotherapy-Related Neurotoxicity
title_full_unstemmed Self-Reported Assessment of the Socio-Economic Impact of Anticancer Chemotherapy-Related Neurotoxicity
title_short Self-Reported Assessment of the Socio-Economic Impact of Anticancer Chemotherapy-Related Neurotoxicity
title_sort self-reported assessment of the socio-economic impact of anticancer chemotherapy-related neurotoxicity
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966709/
https://www.ncbi.nlm.nih.gov/pubmed/36850979
http://dx.doi.org/10.3390/toxics11020104
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