Cargando…

Oral Administration of TrkB Agonist, 7, 8–Dihydroxyflavone Regenerates Hair Cells and Restores Function after Gentamicin–Induced Vestibular Injury in Guinea Pig

The causes of vestibular dysfunction include the loss of hair cells (HCs), synapses beneath the HCs, and nerve fibers. 7, 8–dihydroxyflavone (DHF) mimics the physiological functions of brain-derived neurotrophic factor. We investigated the effects of the orally-administered DHF in the guinea pig cri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kinoshita, Makoto, Fujimoto, Chisato, Iwasaki, Shinichi, Kondo, Kenji, Yamasoba, Tatsuya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966733/ https://www.ncbi.nlm.nih.gov/pubmed/36839815 http://dx.doi.org/10.3390/pharmaceutics15020493

Ejemplares similares

Alteration of Musashi1 Intra-cellular Distribution During Regeneration Following Gentamicin-Induced Hair Cell Loss in the Guinea Pig Crista Ampullaris
por: Kinoshita, Makoto, et al.
Publicado: (2019)

The TrkB agonist, 7,8-dihydroxyflavone, impairs fracture healing in mice
por: Johnstone, Maddison R., et al.
Publicado: (2021)

Beneficial effects of time‐restricted feeding on gentamicin cytotoxicity in mouse cochlea and vestibular organs
por: Gao, Ying, et al.
Publicado: (2022)

7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders
por: Liu, Chaoyang, et al.
Publicado: (2016)

Prediction of Vestibular Dysfunction by Applying Machine Learning Algorithms to Postural Instability
por: Kamogashira, Teru, et al.
Publicado: (2020)

Exploring the Molecular Interactions of 7,8-Dihydroxyflavone and Its Derivatives with TrkB and VEGFR2 Proteins
por: Chitranshi, Nitin, et al.
Publicado: (2015)

Effect of Noisy Galvanic Vestibular Stimulation on Ocular Vestibular-Evoked Myogenic Potentials to Bone-Conducted Vibration
por: Iwasaki, Shinichi, et al.
Publicado: (2017)

Alteration of Vestibular Function in Pediatric Cochlear Implant Recipients
por: Koyama, Hajime, et al.
Publicado: (2021)

Do Small Molecules Activate the TrkB Receptor in the Same Manner as BDNF? Limitations of Published TrkB Low Molecular Agonists and Screening for Novel TrkB Orthosteric Agonists
por: Pankiewicz, Piotr, et al.
Publicado: (2021)

Effect and mechanism of BDNF/TrkB signaling on vestibular compensation
por: Mao, Dehong, et al.
Publicado: (2021)

7, 8-Dihydroxyflavone, a TrkB receptor agonist, provides minimal protection against retinal vascular damage during oxygen-induced ischemic retinopathy
por: Zaitoun, Ismail S., et al.
Publicado: (2021)

Noisy Galvanic Vestibular Stimulation Sustainably Improves Posture in Bilateral Vestibulopathy
por: Fujimoto, Chisato, et al.
Publicado: (2018)

Noisy galvanic vestibular stimulation induces a sustained improvement in body balance in elderly adults
por: Fujimoto, Chisato, et al.
Publicado: (2016)

7,8-Dihydroxyflavone protects neurons against oxygen-glucose deprivation induced apoptosis and activates the TrkB/Akt pathway
por: Zhou, Qinxiang, et al.
Publicado: (2022)

Noisy galvanic vestibular stimulation has a greater ameliorating effect on posture in unstable subjects: a feasibility study
por: Fujimoto, Chisato, et al.
Publicado: (2019)

7,8-Dihydroxyflavone Attenuates Alcohol-Related Behavior in Rat Models of Alcohol Consumption via TrkB in the Ventral Tegmental Area
por: Li, Xin-Xin, et al.
Publicado: (2020)

Vestibular Imaging and Function in Patients With Inner Ear Malformation Presenting With Profound Hearing Loss
por: Dy, Alexander Edward S., et al.
Publicado: (2022)

BDNF Outperforms TrkB Agonist 7,8,3′-THF in Preserving the Auditory Nerve in Deafened Guinea Pigs
por: Vink, Henk A., et al.
Publicado: (2020)

Post-Injury Treatment with 7,8-Dihydroxyflavone, a TrkB Receptor Agonist, Protects against Experimental Traumatic Brain Injury via PI3K/Akt Signaling
por: Wu, Chun-Hu, et al.
Publicado: (2014)

Therapeutic potential of a TrkB agonistic antibody for Alzheimer's disease
por: Wang, Shudan, et al.
Publicado: (2020)

7,8-Dihydroxyflavone, a Small Molecule TrkB Agonist, Improves Spatial Memory and Increases Thin Spine Density in a Mouse Model of Alzheimer Disease-Like Neuronal Loss
por: Castello, Nicholas A., et al.
Publicado: (2014)

Activation of TrkB/Akt signaling by a TrkB receptor agonist improves long-term histological and functional outcomes in experimental intracerebral hemorrhage
por: Wu, Chun-Hu, et al.
Publicado: (2019)

Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice
por: Zhao, Zhenlei, et al.
Publicado: (2020)

The Role of Neck Input in Producing Corrective Saccades in the Head Impulse Test
por: Iwasaki, Shinichi, et al.
Publicado: (2022)

The effect of self‐management vestibular rehabilitation on persistent postural‐perceptual dizziness
por: Fujimoto, Chisato, et al.
Publicado: (2023)

7,8-Dihydroxyflavone alleviates apoptosis and inflammation induced by retinal ischemia-reperfusion injury via activating TrkB/Akt/NF-kB signaling pathway
por: Yu, Aihua, et al.
Publicado: (2022)

Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity
por: Vidaurre, Ó G, et al.
Publicado: (2012)

Appetite Enhancement and Weight Gain by Peripheral Administration of TrkB Agonists in Non-Human Primates
por: Lin, John C., et al.
Publicado: (2008)

A Monoclonal Antibody TrkB Receptor Agonist as a Potential Therapeutic for Huntington’s Disease
por: Todd, Daniel, et al.
Publicado: (2014)

Chronic TrkB agonist treatment in old age does not mitigate diaphragm neuromuscular dysfunction
por: Greising, Sarah M., et al.
Publicado: (2017)

Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress
por: Kamogashira, Teru, et al.
Publicado: (2017)

Pyrroloquinoline quinone (PQQ) protects mitochondrial function of HEI-OC1 cells under premature senescence
por: Gao, Ying, et al.
Publicado: (2022)

Effects of pyrroloquinoline quinone on noise-induced and age-related hearing loss in mice
por: Gao, Ying, et al.
Publicado: (2022)

Author Correction: Pyrroloquinoline quinone (PQQ) protects mitochondrial function of HEI-OC1 cells under premature senescence
por: Gao, Ying, et al.
Publicado: (2022)

TrkB-Targeted Therapy for Mucoepidermoid Carcinoma
por: Wagner, Vivian P., et al.
Publicado: (2020)

Preceding Balance Disorders Affect Vestibular Function in Persistent Postural-Perceptual Dizziness
por: Oka, Mineko, et al.
Publicado: (2023)

Long-Term Progression and Rapid Decline in Hearing Loss in Patients with a Point Mutation at Nucleotide 3243 of the Mitochondrial DNA
por: Sakata, Aki, et al.
Publicado: (2022)

Actions of the TrkB Agonist Antibody ZEB85 in Regulating the Architecture and Synaptic Plasticity in Hippocampal Neurons
por: Tacke, Charlotte, et al.
Publicado: (2022)

Taste Neurons Consist of Both a Large TrkB-Receptor-Dependent and a Small TrkB-Receptor-Independent Subpopulation
por: Fei, Da, et al.
Publicado: (2013)

The Role of BDNF-TrkB Signaling in the Pathogenesis of PTSD
por: Green, Christopher R., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_akl03dd5lkovcklk2cohrfmso0