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Self-Reported Asthma Is Associated with Reduced Sperm Count—A Cross-Sectional Study of More than 6000 Young Men from the General Population

Asthma is driven by an inflammatory response that may impact testicular function. In this cross-sectional study, we investigated the association between self-reported asthma and testicular function (semen parameters, reproductive hormone levels), and determined whether potential further inflammation...

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Autores principales: Pedersen, Marc K., Bräuner, Elvira V., Hansen, Ann H., Hansen, Laura S., Jensen, Tina K., Jørgensen, Niels, Priskorn, Lærke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966775/
https://www.ncbi.nlm.nih.gov/pubmed/36836635
http://dx.doi.org/10.3390/life13020278
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author Pedersen, Marc K.
Bräuner, Elvira V.
Hansen, Ann H.
Hansen, Laura S.
Jensen, Tina K.
Jørgensen, Niels
Priskorn, Lærke
author_facet Pedersen, Marc K.
Bräuner, Elvira V.
Hansen, Ann H.
Hansen, Laura S.
Jensen, Tina K.
Jørgensen, Niels
Priskorn, Lærke
author_sort Pedersen, Marc K.
collection PubMed
description Asthma is driven by an inflammatory response that may impact testicular function. In this cross-sectional study, we investigated the association between self-reported asthma and testicular function (semen parameters, reproductive hormone levels), and determined whether potential further inflammation due to self-reported allergy modified this association. A total of 6177 men from the general population completed a questionnaire including information on doctor-diagnosed asthma or allergy, had a physical examination, delivered a semen sample, and had a blood sample drawn. Multiple linear regression analyses were performed. A total of 656 (10.6%) men reported having ever been diagnosed with asthma. Generally, self-reported asthma was consistently associated with a poorer testicular function; however, few estimates were statistically significant. Specifically, self-reported asthma was associated with statistically significant lower total sperm count [median: 133 vs. 145 million; adjusted β (95% CI): −0.18 (−0.33 to −0.04) million on cubic-root-transformed scale] and borderline statistically significant lower sperm concentration compared with no self-reported asthma. The association between asthma and total sperm count was of similar magnitude among men with and without allergy. In conclusion, men with self-reported asthma had poorer testicular function than men without asthma. However, the cross-sectional design of the study limits ascertainment of causality.
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spelling pubmed-99667752023-02-26 Self-Reported Asthma Is Associated with Reduced Sperm Count—A Cross-Sectional Study of More than 6000 Young Men from the General Population Pedersen, Marc K. Bräuner, Elvira V. Hansen, Ann H. Hansen, Laura S. Jensen, Tina K. Jørgensen, Niels Priskorn, Lærke Life (Basel) Article Asthma is driven by an inflammatory response that may impact testicular function. In this cross-sectional study, we investigated the association between self-reported asthma and testicular function (semen parameters, reproductive hormone levels), and determined whether potential further inflammation due to self-reported allergy modified this association. A total of 6177 men from the general population completed a questionnaire including information on doctor-diagnosed asthma or allergy, had a physical examination, delivered a semen sample, and had a blood sample drawn. Multiple linear regression analyses were performed. A total of 656 (10.6%) men reported having ever been diagnosed with asthma. Generally, self-reported asthma was consistently associated with a poorer testicular function; however, few estimates were statistically significant. Specifically, self-reported asthma was associated with statistically significant lower total sperm count [median: 133 vs. 145 million; adjusted β (95% CI): −0.18 (−0.33 to −0.04) million on cubic-root-transformed scale] and borderline statistically significant lower sperm concentration compared with no self-reported asthma. The association between asthma and total sperm count was of similar magnitude among men with and without allergy. In conclusion, men with self-reported asthma had poorer testicular function than men without asthma. However, the cross-sectional design of the study limits ascertainment of causality. MDPI 2023-01-19 /pmc/articles/PMC9966775/ /pubmed/36836635 http://dx.doi.org/10.3390/life13020278 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pedersen, Marc K.
Bräuner, Elvira V.
Hansen, Ann H.
Hansen, Laura S.
Jensen, Tina K.
Jørgensen, Niels
Priskorn, Lærke
Self-Reported Asthma Is Associated with Reduced Sperm Count—A Cross-Sectional Study of More than 6000 Young Men from the General Population
title Self-Reported Asthma Is Associated with Reduced Sperm Count—A Cross-Sectional Study of More than 6000 Young Men from the General Population
title_full Self-Reported Asthma Is Associated with Reduced Sperm Count—A Cross-Sectional Study of More than 6000 Young Men from the General Population
title_fullStr Self-Reported Asthma Is Associated with Reduced Sperm Count—A Cross-Sectional Study of More than 6000 Young Men from the General Population
title_full_unstemmed Self-Reported Asthma Is Associated with Reduced Sperm Count—A Cross-Sectional Study of More than 6000 Young Men from the General Population
title_short Self-Reported Asthma Is Associated with Reduced Sperm Count—A Cross-Sectional Study of More than 6000 Young Men from the General Population
title_sort self-reported asthma is associated with reduced sperm count—a cross-sectional study of more than 6000 young men from the general population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966775/
https://www.ncbi.nlm.nih.gov/pubmed/36836635
http://dx.doi.org/10.3390/life13020278
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