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Stochastic Modelling of HIV-1 Replication in a CD4 T Cell with an IFN Response

A mathematical model of the human immunodeficiency virus Type 1 (HIV-1) life cycle in CD4 T cells was constructed and calibrated. It describes the activation of the intracellular Type I interferon (IFN-I) response and the IFN-induced suppression of viral replication. The model includes viral replica...

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Autores principales: Sazonov, Igor, Grebennikov, Dmitry, Savinkov, Rostislav, Soboleva, Arina, Pavlishin, Kirill, Meyerhans, Andreas, Bocharov, Gennady
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966781/
https://www.ncbi.nlm.nih.gov/pubmed/36851511
http://dx.doi.org/10.3390/v15020296
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author Sazonov, Igor
Grebennikov, Dmitry
Savinkov, Rostislav
Soboleva, Arina
Pavlishin, Kirill
Meyerhans, Andreas
Bocharov, Gennady
author_facet Sazonov, Igor
Grebennikov, Dmitry
Savinkov, Rostislav
Soboleva, Arina
Pavlishin, Kirill
Meyerhans, Andreas
Bocharov, Gennady
author_sort Sazonov, Igor
collection PubMed
description A mathematical model of the human immunodeficiency virus Type 1 (HIV-1) life cycle in CD4 T cells was constructed and calibrated. It describes the activation of the intracellular Type I interferon (IFN-I) response and the IFN-induced suppression of viral replication. The model includes viral replication inhibition by interferon-induced antiviral factors and their inactivation by the viral proteins Vpu and Vif. Both deterministic and stochastic model formulations are presented. The stochastic model was used to predict efficiency of IFN-I-induced suppression of viral replication in different initial conditions for autocrine and paracrine effects. The probability of virion excretion for various MOIs and various amounts of IFN-I was evaluated and the statistical properties of the heterogeneity of HIV-1 and IFN-I production characterised.
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spelling pubmed-99667812023-02-26 Stochastic Modelling of HIV-1 Replication in a CD4 T Cell with an IFN Response Sazonov, Igor Grebennikov, Dmitry Savinkov, Rostislav Soboleva, Arina Pavlishin, Kirill Meyerhans, Andreas Bocharov, Gennady Viruses Article A mathematical model of the human immunodeficiency virus Type 1 (HIV-1) life cycle in CD4 T cells was constructed and calibrated. It describes the activation of the intracellular Type I interferon (IFN-I) response and the IFN-induced suppression of viral replication. The model includes viral replication inhibition by interferon-induced antiviral factors and their inactivation by the viral proteins Vpu and Vif. Both deterministic and stochastic model formulations are presented. The stochastic model was used to predict efficiency of IFN-I-induced suppression of viral replication in different initial conditions for autocrine and paracrine effects. The probability of virion excretion for various MOIs and various amounts of IFN-I was evaluated and the statistical properties of the heterogeneity of HIV-1 and IFN-I production characterised. MDPI 2023-01-20 /pmc/articles/PMC9966781/ /pubmed/36851511 http://dx.doi.org/10.3390/v15020296 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sazonov, Igor
Grebennikov, Dmitry
Savinkov, Rostislav
Soboleva, Arina
Pavlishin, Kirill
Meyerhans, Andreas
Bocharov, Gennady
Stochastic Modelling of HIV-1 Replication in a CD4 T Cell with an IFN Response
title Stochastic Modelling of HIV-1 Replication in a CD4 T Cell with an IFN Response
title_full Stochastic Modelling of HIV-1 Replication in a CD4 T Cell with an IFN Response
title_fullStr Stochastic Modelling of HIV-1 Replication in a CD4 T Cell with an IFN Response
title_full_unstemmed Stochastic Modelling of HIV-1 Replication in a CD4 T Cell with an IFN Response
title_short Stochastic Modelling of HIV-1 Replication in a CD4 T Cell with an IFN Response
title_sort stochastic modelling of hiv-1 replication in a cd4 t cell with an ifn response
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966781/
https://www.ncbi.nlm.nih.gov/pubmed/36851511
http://dx.doi.org/10.3390/v15020296
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