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Stochastic Modelling of HIV-1 Replication in a CD4 T Cell with an IFN Response
A mathematical model of the human immunodeficiency virus Type 1 (HIV-1) life cycle in CD4 T cells was constructed and calibrated. It describes the activation of the intracellular Type I interferon (IFN-I) response and the IFN-induced suppression of viral replication. The model includes viral replica...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966781/ https://www.ncbi.nlm.nih.gov/pubmed/36851511 http://dx.doi.org/10.3390/v15020296 |
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author | Sazonov, Igor Grebennikov, Dmitry Savinkov, Rostislav Soboleva, Arina Pavlishin, Kirill Meyerhans, Andreas Bocharov, Gennady |
author_facet | Sazonov, Igor Grebennikov, Dmitry Savinkov, Rostislav Soboleva, Arina Pavlishin, Kirill Meyerhans, Andreas Bocharov, Gennady |
author_sort | Sazonov, Igor |
collection | PubMed |
description | A mathematical model of the human immunodeficiency virus Type 1 (HIV-1) life cycle in CD4 T cells was constructed and calibrated. It describes the activation of the intracellular Type I interferon (IFN-I) response and the IFN-induced suppression of viral replication. The model includes viral replication inhibition by interferon-induced antiviral factors and their inactivation by the viral proteins Vpu and Vif. Both deterministic and stochastic model formulations are presented. The stochastic model was used to predict efficiency of IFN-I-induced suppression of viral replication in different initial conditions for autocrine and paracrine effects. The probability of virion excretion for various MOIs and various amounts of IFN-I was evaluated and the statistical properties of the heterogeneity of HIV-1 and IFN-I production characterised. |
format | Online Article Text |
id | pubmed-9966781 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99667812023-02-26 Stochastic Modelling of HIV-1 Replication in a CD4 T Cell with an IFN Response Sazonov, Igor Grebennikov, Dmitry Savinkov, Rostislav Soboleva, Arina Pavlishin, Kirill Meyerhans, Andreas Bocharov, Gennady Viruses Article A mathematical model of the human immunodeficiency virus Type 1 (HIV-1) life cycle in CD4 T cells was constructed and calibrated. It describes the activation of the intracellular Type I interferon (IFN-I) response and the IFN-induced suppression of viral replication. The model includes viral replication inhibition by interferon-induced antiviral factors and their inactivation by the viral proteins Vpu and Vif. Both deterministic and stochastic model formulations are presented. The stochastic model was used to predict efficiency of IFN-I-induced suppression of viral replication in different initial conditions for autocrine and paracrine effects. The probability of virion excretion for various MOIs and various amounts of IFN-I was evaluated and the statistical properties of the heterogeneity of HIV-1 and IFN-I production characterised. MDPI 2023-01-20 /pmc/articles/PMC9966781/ /pubmed/36851511 http://dx.doi.org/10.3390/v15020296 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sazonov, Igor Grebennikov, Dmitry Savinkov, Rostislav Soboleva, Arina Pavlishin, Kirill Meyerhans, Andreas Bocharov, Gennady Stochastic Modelling of HIV-1 Replication in a CD4 T Cell with an IFN Response |
title | Stochastic Modelling of HIV-1 Replication in a CD4 T Cell with an IFN Response |
title_full | Stochastic Modelling of HIV-1 Replication in a CD4 T Cell with an IFN Response |
title_fullStr | Stochastic Modelling of HIV-1 Replication in a CD4 T Cell with an IFN Response |
title_full_unstemmed | Stochastic Modelling of HIV-1 Replication in a CD4 T Cell with an IFN Response |
title_short | Stochastic Modelling of HIV-1 Replication in a CD4 T Cell with an IFN Response |
title_sort | stochastic modelling of hiv-1 replication in a cd4 t cell with an ifn response |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966781/ https://www.ncbi.nlm.nih.gov/pubmed/36851511 http://dx.doi.org/10.3390/v15020296 |
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