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Personalized Sentinel Node Mapping in Endometrial Cancer by the Indocyanine Green Implementation as Single Tracer: A Case Control Study

The main objective was to analyze the rate of bilateral sentinel lymph node (SLN) detection in endometrial cancer using indocyanine green (ICG) as a unique tracer compared to Technetium99 + ICG. As secondary objectives, we analyzed the drainage pattern and factors that might affect the oncological o...

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Autores principales: Cristóbal Quevedo, Ignacio, Cristóbal García, Ignacio, Gracia, Myriam, Garcia-Pineda, Virginia, Alonso-Espias, Maria, Siegrist, Jaime, Diestro, Maria Dolores, Hernández, Alicia, Zapardiel, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966782/
https://www.ncbi.nlm.nih.gov/pubmed/36836404
http://dx.doi.org/10.3390/jpm13020170
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author Cristóbal Quevedo, Ignacio
Cristóbal García, Ignacio
Gracia, Myriam
Garcia-Pineda, Virginia
Alonso-Espias, Maria
Siegrist, Jaime
Diestro, Maria Dolores
Hernández, Alicia
Zapardiel, Ignacio
author_facet Cristóbal Quevedo, Ignacio
Cristóbal García, Ignacio
Gracia, Myriam
Garcia-Pineda, Virginia
Alonso-Espias, Maria
Siegrist, Jaime
Diestro, Maria Dolores
Hernández, Alicia
Zapardiel, Ignacio
author_sort Cristóbal Quevedo, Ignacio
collection PubMed
description The main objective was to analyze the rate of bilateral sentinel lymph node (SLN) detection in endometrial cancer using indocyanine green (ICG) as a unique tracer compared to Technetium99 + ICG. As secondary objectives, we analyzed the drainage pattern and factors that might affect the oncological outcomes. A case-control ambispective study was carried out on consecutive patients at our center. Data on the SLN biopsy with ICG collected prospectively were compared to retrospective data on the use of a double-tracer technique including Technetium99 + ICG. In total, 194 patients were enrolled and assigned to both groups, in which the group with both tracers (controls) included 107 (54.9%) patients and the ICG-alone group (cases) included 87 (45.1%) patients. The rate of bilateral drainage was significantly higher in the ICG group (98.9% vs. 89.7%; p = 0.013). The median number of nodes retrieved was higher in the control group (three vs. two nodes; p < 0.01). We did not find survival differences associated with the tracer used (p = 0.85). We showed significant differences in terms of disease-free survival regarding the SLN location (p < 0.01), and obturator fossa retrieved nodes showed better prognosis compared to external iliac. The use of ICG as a single tracer for SLN detection in endometrial cancer patients seemed to obtain higher rates of bilateral detection with similar oncological outcomes.
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spelling pubmed-99667822023-02-26 Personalized Sentinel Node Mapping in Endometrial Cancer by the Indocyanine Green Implementation as Single Tracer: A Case Control Study Cristóbal Quevedo, Ignacio Cristóbal García, Ignacio Gracia, Myriam Garcia-Pineda, Virginia Alonso-Espias, Maria Siegrist, Jaime Diestro, Maria Dolores Hernández, Alicia Zapardiel, Ignacio J Pers Med Article The main objective was to analyze the rate of bilateral sentinel lymph node (SLN) detection in endometrial cancer using indocyanine green (ICG) as a unique tracer compared to Technetium99 + ICG. As secondary objectives, we analyzed the drainage pattern and factors that might affect the oncological outcomes. A case-control ambispective study was carried out on consecutive patients at our center. Data on the SLN biopsy with ICG collected prospectively were compared to retrospective data on the use of a double-tracer technique including Technetium99 + ICG. In total, 194 patients were enrolled and assigned to both groups, in which the group with both tracers (controls) included 107 (54.9%) patients and the ICG-alone group (cases) included 87 (45.1%) patients. The rate of bilateral drainage was significantly higher in the ICG group (98.9% vs. 89.7%; p = 0.013). The median number of nodes retrieved was higher in the control group (three vs. two nodes; p < 0.01). We did not find survival differences associated with the tracer used (p = 0.85). We showed significant differences in terms of disease-free survival regarding the SLN location (p < 0.01), and obturator fossa retrieved nodes showed better prognosis compared to external iliac. The use of ICG as a single tracer for SLN detection in endometrial cancer patients seemed to obtain higher rates of bilateral detection with similar oncological outcomes. MDPI 2023-01-18 /pmc/articles/PMC9966782/ /pubmed/36836404 http://dx.doi.org/10.3390/jpm13020170 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cristóbal Quevedo, Ignacio
Cristóbal García, Ignacio
Gracia, Myriam
Garcia-Pineda, Virginia
Alonso-Espias, Maria
Siegrist, Jaime
Diestro, Maria Dolores
Hernández, Alicia
Zapardiel, Ignacio
Personalized Sentinel Node Mapping in Endometrial Cancer by the Indocyanine Green Implementation as Single Tracer: A Case Control Study
title Personalized Sentinel Node Mapping in Endometrial Cancer by the Indocyanine Green Implementation as Single Tracer: A Case Control Study
title_full Personalized Sentinel Node Mapping in Endometrial Cancer by the Indocyanine Green Implementation as Single Tracer: A Case Control Study
title_fullStr Personalized Sentinel Node Mapping in Endometrial Cancer by the Indocyanine Green Implementation as Single Tracer: A Case Control Study
title_full_unstemmed Personalized Sentinel Node Mapping in Endometrial Cancer by the Indocyanine Green Implementation as Single Tracer: A Case Control Study
title_short Personalized Sentinel Node Mapping in Endometrial Cancer by the Indocyanine Green Implementation as Single Tracer: A Case Control Study
title_sort personalized sentinel node mapping in endometrial cancer by the indocyanine green implementation as single tracer: a case control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966782/
https://www.ncbi.nlm.nih.gov/pubmed/36836404
http://dx.doi.org/10.3390/jpm13020170
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