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Projections from the Rostral Zona Incerta to the Thalamic Paraventricular Nucleus Mediate Nociceptive Neurotransmission in Mice
Zona incerta (ZI) is an integrative subthalamic region in nociceptive neurotransmission. Previous studies demonstrated that the rostral ZI (ZIR) is an important gamma–aminobutyric acid-ergic (GABAergic) source to the thalamic paraventricular nucleus (PVT), but whether the ZIR–PVT pathway participate...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966812/ https://www.ncbi.nlm.nih.gov/pubmed/36837844 http://dx.doi.org/10.3390/metabo13020226 |
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author | Wu, Feng-Ling Chen, Si-Hai Li, Jia-Ni Zhao, Liu-Jie Wu, Xue-Mei Hong, Jie Zhu, Ke-Hua Sun, Han-Xue Shi, Su-Juan Mao, E Zang, Wei-Dong Cao, Jing Kou, Zhen-Zhen Li, Yun-Qing |
author_facet | Wu, Feng-Ling Chen, Si-Hai Li, Jia-Ni Zhao, Liu-Jie Wu, Xue-Mei Hong, Jie Zhu, Ke-Hua Sun, Han-Xue Shi, Su-Juan Mao, E Zang, Wei-Dong Cao, Jing Kou, Zhen-Zhen Li, Yun-Qing |
author_sort | Wu, Feng-Ling |
collection | PubMed |
description | Zona incerta (ZI) is an integrative subthalamic region in nociceptive neurotransmission. Previous studies demonstrated that the rostral ZI (ZIR) is an important gamma–aminobutyric acid-ergic (GABAergic) source to the thalamic paraventricular nucleus (PVT), but whether the ZIR–PVT pathway participates in nociceptive modulation is still unclear. Therefore, our investigation utilized anatomical tracing, fiber photometry, chemogenetic, optogenetic and local pharmacological approaches to investigate the roles of the ZIR(GABA+)–PVT pathway in nociceptive neurotransmission in mice. We found that projections from the GABAergic neurons in ZIR to PVT were involved in nociceptive neurotransmission. Furthermore, chemogenetic and optogenetic activation of the ZIR(GABA+)–PVT pathway alleviates pain, whereas inhibiting the activities of the ZIR(GABA+)-PVT circuit induces mechanical hypersensitivity and partial heat hyperalgesia. Importantly, in vivo pharmacology combined with optogenetics revealed that the GABA-A receptor (GABA(A)R) is crucial for GABAergic inhibition from ZIR to PVT. Our data suggest that the ZIR(GABA+)–PVT pathway acts through GABA(A)R-expressing glutamatergic neurons in PVT mediates nociceptive neurotransmission. |
format | Online Article Text |
id | pubmed-9966812 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99668122023-02-26 Projections from the Rostral Zona Incerta to the Thalamic Paraventricular Nucleus Mediate Nociceptive Neurotransmission in Mice Wu, Feng-Ling Chen, Si-Hai Li, Jia-Ni Zhao, Liu-Jie Wu, Xue-Mei Hong, Jie Zhu, Ke-Hua Sun, Han-Xue Shi, Su-Juan Mao, E Zang, Wei-Dong Cao, Jing Kou, Zhen-Zhen Li, Yun-Qing Metabolites Article Zona incerta (ZI) is an integrative subthalamic region in nociceptive neurotransmission. Previous studies demonstrated that the rostral ZI (ZIR) is an important gamma–aminobutyric acid-ergic (GABAergic) source to the thalamic paraventricular nucleus (PVT), but whether the ZIR–PVT pathway participates in nociceptive modulation is still unclear. Therefore, our investigation utilized anatomical tracing, fiber photometry, chemogenetic, optogenetic and local pharmacological approaches to investigate the roles of the ZIR(GABA+)–PVT pathway in nociceptive neurotransmission in mice. We found that projections from the GABAergic neurons in ZIR to PVT were involved in nociceptive neurotransmission. Furthermore, chemogenetic and optogenetic activation of the ZIR(GABA+)–PVT pathway alleviates pain, whereas inhibiting the activities of the ZIR(GABA+)-PVT circuit induces mechanical hypersensitivity and partial heat hyperalgesia. Importantly, in vivo pharmacology combined with optogenetics revealed that the GABA-A receptor (GABA(A)R) is crucial for GABAergic inhibition from ZIR to PVT. Our data suggest that the ZIR(GABA+)–PVT pathway acts through GABA(A)R-expressing glutamatergic neurons in PVT mediates nociceptive neurotransmission. MDPI 2023-02-03 /pmc/articles/PMC9966812/ /pubmed/36837844 http://dx.doi.org/10.3390/metabo13020226 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wu, Feng-Ling Chen, Si-Hai Li, Jia-Ni Zhao, Liu-Jie Wu, Xue-Mei Hong, Jie Zhu, Ke-Hua Sun, Han-Xue Shi, Su-Juan Mao, E Zang, Wei-Dong Cao, Jing Kou, Zhen-Zhen Li, Yun-Qing Projections from the Rostral Zona Incerta to the Thalamic Paraventricular Nucleus Mediate Nociceptive Neurotransmission in Mice |
title | Projections from the Rostral Zona Incerta to the Thalamic Paraventricular Nucleus Mediate Nociceptive Neurotransmission in Mice |
title_full | Projections from the Rostral Zona Incerta to the Thalamic Paraventricular Nucleus Mediate Nociceptive Neurotransmission in Mice |
title_fullStr | Projections from the Rostral Zona Incerta to the Thalamic Paraventricular Nucleus Mediate Nociceptive Neurotransmission in Mice |
title_full_unstemmed | Projections from the Rostral Zona Incerta to the Thalamic Paraventricular Nucleus Mediate Nociceptive Neurotransmission in Mice |
title_short | Projections from the Rostral Zona Incerta to the Thalamic Paraventricular Nucleus Mediate Nociceptive Neurotransmission in Mice |
title_sort | projections from the rostral zona incerta to the thalamic paraventricular nucleus mediate nociceptive neurotransmission in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966812/ https://www.ncbi.nlm.nih.gov/pubmed/36837844 http://dx.doi.org/10.3390/metabo13020226 |
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