A New Regularization for Deep Learning-Based Segmentation of Images with Fine Structures and Low Contrast

Deep learning methods have achieved outstanding results in many image processing and computer vision tasks, such as image segmentation. However, they usually do not consider spatial dependencies among pixels/voxels in the image. To obtain better results, some methods have been proposed to apply classic spatial regularization, such as total variation, into deep learning models. However, for some challenging images, especially those with fine structures and low contrast, classical regularizations are not suitable. We derived a new regularization to improve the connectivity of segmentation results and make it applicable to deep learning. Our experimental results show that for both deep learning methods and unsupervised methods, the proposed method can improve performance by increasing connectivity and dealing with low contrast and, therefore, enhance segmentation results.