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OCT Findings in Patients with Methamphetamine Use Disorder

Purpose: In the present study, the purpose was to examine the results of optical coherence tomography (OCT) measurements in patients diagnosed with methamphetamine use disorder (MUD) by comparing them with healthy controls. Materials and Methods: A total of 114 eyes were evaluated in this study (27...

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Autores principales: Kaya, Şüheda, Kaya, Mehmet Kaan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967004/
https://www.ncbi.nlm.nih.gov/pubmed/36836542
http://dx.doi.org/10.3390/jpm13020308
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author Kaya, Şüheda
Kaya, Mehmet Kaan
author_facet Kaya, Şüheda
Kaya, Mehmet Kaan
author_sort Kaya, Şüheda
collection PubMed
description Purpose: In the present study, the purpose was to examine the results of optical coherence tomography (OCT) measurements in patients diagnosed with methamphetamine use disorder (MUD) by comparing them with healthy controls. Materials and Methods: A total of 114 eyes were evaluated in this study (27 patients and 30 control group participants). After detailed biomicroscopic examinations of all participants by the same ophthalmologist, both eyes were evaluated by OCT. The retinal nerve fiber layer thickness (RNFL) and macular thickness were calculated from OCT. Results: No statistically significant differences were detected between the demographic data of the patient and control groups (p > 0.05). When OCT findings were evaluated, macular thickness and volume were not different between the groups (p > 0.05). With respect to RNFL, the left eye superior, inferior, temporal, and nasal quadrants, as well as the left eye’s total measurements were found to be thicker than those of controls (p < 0.05). In both eyes, the left eye nasal quadrant and APIS total score were negatively correlated, the total RNLF measurement of the right eye and APIS motivation subscale score were negatively correlated, central macular thickness and the APIS motivation subscale score were positively correlated, and the APIS substance use characteristics subscale score and left eye temporal quadrant RNLF measurement were positively correlated. Conclusion: Our study is the first to evaluate addiction severity and OCT findings in MUD. However, this study needs to be supported by further studies so that OCT findings, which can be used as an effective method for demonstrating possible neurodegeneration in methamphetamine use disorder, gain importance.
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spelling pubmed-99670042023-02-26 OCT Findings in Patients with Methamphetamine Use Disorder Kaya, Şüheda Kaya, Mehmet Kaan J Pers Med Article Purpose: In the present study, the purpose was to examine the results of optical coherence tomography (OCT) measurements in patients diagnosed with methamphetamine use disorder (MUD) by comparing them with healthy controls. Materials and Methods: A total of 114 eyes were evaluated in this study (27 patients and 30 control group participants). After detailed biomicroscopic examinations of all participants by the same ophthalmologist, both eyes were evaluated by OCT. The retinal nerve fiber layer thickness (RNFL) and macular thickness were calculated from OCT. Results: No statistically significant differences were detected between the demographic data of the patient and control groups (p > 0.05). When OCT findings were evaluated, macular thickness and volume were not different between the groups (p > 0.05). With respect to RNFL, the left eye superior, inferior, temporal, and nasal quadrants, as well as the left eye’s total measurements were found to be thicker than those of controls (p < 0.05). In both eyes, the left eye nasal quadrant and APIS total score were negatively correlated, the total RNLF measurement of the right eye and APIS motivation subscale score were negatively correlated, central macular thickness and the APIS motivation subscale score were positively correlated, and the APIS substance use characteristics subscale score and left eye temporal quadrant RNLF measurement were positively correlated. Conclusion: Our study is the first to evaluate addiction severity and OCT findings in MUD. However, this study needs to be supported by further studies so that OCT findings, which can be used as an effective method for demonstrating possible neurodegeneration in methamphetamine use disorder, gain importance. MDPI 2023-02-10 /pmc/articles/PMC9967004/ /pubmed/36836542 http://dx.doi.org/10.3390/jpm13020308 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kaya, Şüheda
Kaya, Mehmet Kaan
OCT Findings in Patients with Methamphetamine Use Disorder
title OCT Findings in Patients with Methamphetamine Use Disorder
title_full OCT Findings in Patients with Methamphetamine Use Disorder
title_fullStr OCT Findings in Patients with Methamphetamine Use Disorder
title_full_unstemmed OCT Findings in Patients with Methamphetamine Use Disorder
title_short OCT Findings in Patients with Methamphetamine Use Disorder
title_sort oct findings in patients with methamphetamine use disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967004/
https://www.ncbi.nlm.nih.gov/pubmed/36836542
http://dx.doi.org/10.3390/jpm13020308
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