Clinical Evaluation Based on a New Approach to Improve the Accuracy of 4β-Hydroxycholesterol Measurement as a Biomarker of CYP3A4 Activity

This study examines 4β-Hydroxycholesterol (4β-HC), which is considered to be a potential marker for the CYP3A4 induction of new chemical entities (NCEs) in drug development. To ensure the use of 4β-HC as a practical biomarker, it is necessary to accurately measure 4β-HC and demonstrate that CYP3A4 i...

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Detalles Bibliográficos
Autores principales: Taya, Yuki, Mizunaga, Mari, Nakao, Shunsuke, Jutanom, Mirinthorn, Shimizu, Naoki, Nomura, Yukihiro, Nakagawa, Kiyotaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967035/
https://www.ncbi.nlm.nih.gov/pubmed/36838563
http://dx.doi.org/10.3390/molecules28041576

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967035/
https://www.ncbi.nlm.nih.gov/pubmed/36838563
http://dx.doi.org/10.3390/molecules28041576

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