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Genome Analysis Identifies a Novel Type III Secretion System (T3SS) Category in Vibrio Species

The nanomachine referred to as the type III secretion system (T3SS) is used by many Gram-negative pathogens or symbionts to inject their effector proteins into host cells to promote their infections or symbioses. Among the genera possessing T3SS is Vibrio, which consists of diverse species of Gammap...

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Autores principales: Zakaria, Douaa, Matsuda, Shigeaki, Iida, Tetsuya, Hayashi, Tetsuya, Arita, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967039/
https://www.ncbi.nlm.nih.gov/pubmed/36838254
http://dx.doi.org/10.3390/microorganisms11020290
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author Zakaria, Douaa
Matsuda, Shigeaki
Iida, Tetsuya
Hayashi, Tetsuya
Arita, Masanori
author_facet Zakaria, Douaa
Matsuda, Shigeaki
Iida, Tetsuya
Hayashi, Tetsuya
Arita, Masanori
author_sort Zakaria, Douaa
collection PubMed
description The nanomachine referred to as the type III secretion system (T3SS) is used by many Gram-negative pathogens or symbionts to inject their effector proteins into host cells to promote their infections or symbioses. Among the genera possessing T3SS is Vibrio, which consists of diverse species of Gammaproteobacteria including human pathogenic species and inhabits aquatic environments. We describe the genetic overview of the T3SS gene clusters in Vibrio through a phylogenetic analysis from 48 bacterial strains and a gene order analysis of the two previously known categories in Vibrio (T3SS1 and T3SS2). Through this analysis we identified a new T3SS category (named T3SS3) that shares similar core and related proteins (effectors, translocons, and chaperones) with the Ssa-Esc family of T3SSs in Salmonella, Shewanella, and Sodalis. The high similarity between T3SS3 and the Ssa-Esc family suggests a possibility of genetic exchange among marine bacteria with similar habitats.
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spelling pubmed-99670392023-02-26 Genome Analysis Identifies a Novel Type III Secretion System (T3SS) Category in Vibrio Species Zakaria, Douaa Matsuda, Shigeaki Iida, Tetsuya Hayashi, Tetsuya Arita, Masanori Microorganisms Article The nanomachine referred to as the type III secretion system (T3SS) is used by many Gram-negative pathogens or symbionts to inject their effector proteins into host cells to promote their infections or symbioses. Among the genera possessing T3SS is Vibrio, which consists of diverse species of Gammaproteobacteria including human pathogenic species and inhabits aquatic environments. We describe the genetic overview of the T3SS gene clusters in Vibrio through a phylogenetic analysis from 48 bacterial strains and a gene order analysis of the two previously known categories in Vibrio (T3SS1 and T3SS2). Through this analysis we identified a new T3SS category (named T3SS3) that shares similar core and related proteins (effectors, translocons, and chaperones) with the Ssa-Esc family of T3SSs in Salmonella, Shewanella, and Sodalis. The high similarity between T3SS3 and the Ssa-Esc family suggests a possibility of genetic exchange among marine bacteria with similar habitats. MDPI 2023-01-22 /pmc/articles/PMC9967039/ /pubmed/36838254 http://dx.doi.org/10.3390/microorganisms11020290 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zakaria, Douaa
Matsuda, Shigeaki
Iida, Tetsuya
Hayashi, Tetsuya
Arita, Masanori
Genome Analysis Identifies a Novel Type III Secretion System (T3SS) Category in Vibrio Species
title Genome Analysis Identifies a Novel Type III Secretion System (T3SS) Category in Vibrio Species
title_full Genome Analysis Identifies a Novel Type III Secretion System (T3SS) Category in Vibrio Species
title_fullStr Genome Analysis Identifies a Novel Type III Secretion System (T3SS) Category in Vibrio Species
title_full_unstemmed Genome Analysis Identifies a Novel Type III Secretion System (T3SS) Category in Vibrio Species
title_short Genome Analysis Identifies a Novel Type III Secretion System (T3SS) Category in Vibrio Species
title_sort genome analysis identifies a novel type iii secretion system (t3ss) category in vibrio species
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967039/
https://www.ncbi.nlm.nih.gov/pubmed/36838254
http://dx.doi.org/10.3390/microorganisms11020290
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