Cargando…

Expanded Polytetrafluoroethylene Membranes for Vascular Stent Coating: Manufacturing, Biomedical and Surgical Applications, Innovations and Case Reports

Coated stents are defined as innovative stents surrounded by a thin polymer membrane based on polytetrafluoroethylene (PTFE)useful in the treatment of numerous vascular pathologies. Endovascular methodology involves the use of such devices to restore blood flow in small-, medium- and large-calibre a...

Descripción completa

Detalles Bibliográficos
Autores principales: Cassano, Roberta, Perri, Paolo, Esposito, Antonio, Intrieri, Francesco, Sole, Roberta, Curcio, Federica, Trombino, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967047/
https://www.ncbi.nlm.nih.gov/pubmed/36837743
http://dx.doi.org/10.3390/membranes13020240
_version_ 1784897168016932864
author Cassano, Roberta
Perri, Paolo
Esposito, Antonio
Intrieri, Francesco
Sole, Roberta
Curcio, Federica
Trombino, Sonia
author_facet Cassano, Roberta
Perri, Paolo
Esposito, Antonio
Intrieri, Francesco
Sole, Roberta
Curcio, Federica
Trombino, Sonia
author_sort Cassano, Roberta
collection PubMed
description Coated stents are defined as innovative stents surrounded by a thin polymer membrane based on polytetrafluoroethylene (PTFE)useful in the treatment of numerous vascular pathologies. Endovascular methodology involves the use of such devices to restore blood flow in small-, medium- and large-calibre arteries, both centrally and peripherally. These membranes cross the stent struts and act as a physical barrier to block the growth of intimal tissue in the lumen, preventing so-called intimal hyperplasia and late stent thrombosis. PTFE for vascular applications is known as expanded polytetrafluoroethylene (e-PTFE) and it can be rolled up to form a thin multilayer membrane expandable by 4 to 5 times its original diameter. This membrane plays an important role in initiating the restenotic process because wrapped graft stent could be used as the treatment option for trauma devices during emergency situations and to treat a number of pathological vascular disease. In this review, we will investigate the multidisciplinary techniques used for the production of e-PTFE membranes, the advantages and disadvantages of their use, the innovations and the results in biomedical and surgery field when used to cover graft stents.
format Online
Article
Text
id pubmed-9967047
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99670472023-02-26 Expanded Polytetrafluoroethylene Membranes for Vascular Stent Coating: Manufacturing, Biomedical and Surgical Applications, Innovations and Case Reports Cassano, Roberta Perri, Paolo Esposito, Antonio Intrieri, Francesco Sole, Roberta Curcio, Federica Trombino, Sonia Membranes (Basel) Review Coated stents are defined as innovative stents surrounded by a thin polymer membrane based on polytetrafluoroethylene (PTFE)useful in the treatment of numerous vascular pathologies. Endovascular methodology involves the use of such devices to restore blood flow in small-, medium- and large-calibre arteries, both centrally and peripherally. These membranes cross the stent struts and act as a physical barrier to block the growth of intimal tissue in the lumen, preventing so-called intimal hyperplasia and late stent thrombosis. PTFE for vascular applications is known as expanded polytetrafluoroethylene (e-PTFE) and it can be rolled up to form a thin multilayer membrane expandable by 4 to 5 times its original diameter. This membrane plays an important role in initiating the restenotic process because wrapped graft stent could be used as the treatment option for trauma devices during emergency situations and to treat a number of pathological vascular disease. In this review, we will investigate the multidisciplinary techniques used for the production of e-PTFE membranes, the advantages and disadvantages of their use, the innovations and the results in biomedical and surgery field when used to cover graft stents. MDPI 2023-02-17 /pmc/articles/PMC9967047/ /pubmed/36837743 http://dx.doi.org/10.3390/membranes13020240 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cassano, Roberta
Perri, Paolo
Esposito, Antonio
Intrieri, Francesco
Sole, Roberta
Curcio, Federica
Trombino, Sonia
Expanded Polytetrafluoroethylene Membranes for Vascular Stent Coating: Manufacturing, Biomedical and Surgical Applications, Innovations and Case Reports
title Expanded Polytetrafluoroethylene Membranes for Vascular Stent Coating: Manufacturing, Biomedical and Surgical Applications, Innovations and Case Reports
title_full Expanded Polytetrafluoroethylene Membranes for Vascular Stent Coating: Manufacturing, Biomedical and Surgical Applications, Innovations and Case Reports
title_fullStr Expanded Polytetrafluoroethylene Membranes for Vascular Stent Coating: Manufacturing, Biomedical and Surgical Applications, Innovations and Case Reports
title_full_unstemmed Expanded Polytetrafluoroethylene Membranes for Vascular Stent Coating: Manufacturing, Biomedical and Surgical Applications, Innovations and Case Reports
title_short Expanded Polytetrafluoroethylene Membranes for Vascular Stent Coating: Manufacturing, Biomedical and Surgical Applications, Innovations and Case Reports
title_sort expanded polytetrafluoroethylene membranes for vascular stent coating: manufacturing, biomedical and surgical applications, innovations and case reports
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967047/
https://www.ncbi.nlm.nih.gov/pubmed/36837743
http://dx.doi.org/10.3390/membranes13020240
work_keys_str_mv AT cassanoroberta expandedpolytetrafluoroethylenemembranesforvascularstentcoatingmanufacturingbiomedicalandsurgicalapplicationsinnovationsandcasereports
AT perripaolo expandedpolytetrafluoroethylenemembranesforvascularstentcoatingmanufacturingbiomedicalandsurgicalapplicationsinnovationsandcasereports
AT espositoantonio expandedpolytetrafluoroethylenemembranesforvascularstentcoatingmanufacturingbiomedicalandsurgicalapplicationsinnovationsandcasereports
AT intrierifrancesco expandedpolytetrafluoroethylenemembranesforvascularstentcoatingmanufacturingbiomedicalandsurgicalapplicationsinnovationsandcasereports
AT soleroberta expandedpolytetrafluoroethylenemembranesforvascularstentcoatingmanufacturingbiomedicalandsurgicalapplicationsinnovationsandcasereports
AT curciofederica expandedpolytetrafluoroethylenemembranesforvascularstentcoatingmanufacturingbiomedicalandsurgicalapplicationsinnovationsandcasereports
AT trombinosonia expandedpolytetrafluoroethylenemembranesforvascularstentcoatingmanufacturingbiomedicalandsurgicalapplicationsinnovationsandcasereports