(S)-N-Benzyl-1-phenyl-3,4-dihydroisoqunoline-2(1H)-carboxamide Derivatives, Multi-Target Inhibitors of Monoamine Oxidase and Cholinesterase: Design, Synthesis, and Biological Activity

A series of (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide derivatives was synthesized and evaluated for inhibitory activity against monoamine oxidase (MAO)-A and-B, acetylcholine esterase (AChE), and butyrylcholine esterase (BChE). Four compounds (2i, 2p, 2t, and 2v) showed good inhibitory...

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Detalles Bibliográficos
Autores principales: Jin, Qing-Hao, Zhang, Li-Ping, Zhang, Shan-Shan, Zhuang, Dai-Na, Zhang, Chu-Yu, Zheng, Zhou-Jun, Guan, Li-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967051/
https://www.ncbi.nlm.nih.gov/pubmed/36838642
http://dx.doi.org/10.3390/molecules28041654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967051/
https://www.ncbi.nlm.nih.gov/pubmed/36838642
http://dx.doi.org/10.3390/molecules28041654

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