Cargando…

(S)-N-Benzyl-1-phenyl-3,4-dihydroisoqunoline-2(1H)-carboxamide Derivatives, Multi-Target Inhibitors of Monoamine Oxidase and Cholinesterase: Design, Synthesis, and Biological Activity

A series of (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide derivatives was synthesized and evaluated for inhibitory activity against monoamine oxidase (MAO)-A and-B, acetylcholine esterase (AChE), and butyrylcholine esterase (BChE). Four compounds (2i, 2p, 2t, and 2v) showed good inhibitory...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jin, Qing-Hao, Zhang, Li-Ping, Zhang, Shan-Shan, Zhuang, Dai-Na, Zhang, Chu-Yu, Zheng, Zhou-Jun, Guan, Li-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967051/ https://www.ncbi.nlm.nih.gov/pubmed/36838642 http://dx.doi.org/10.3390/molecules28041654

Ejemplares similares

N-Hydroxy-N-Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases
por: Bautista-Aguilera, Óscar M., et al.
Publicado: (2022)

1-Benzyl-N-methyl-1H-pyrrole-2-carboxamide
por: Zeng, Xiang Chao, et al.
Publicado: (2010)

Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities
por: Chrienova, Zofia, et al.
Publicado: (2022)

Effect of Alkaloids Isolated from Phyllodium pulchellum on Monoamine Levels and Monoamine Oxidase Activity in Rat Brain
por: Cai, Lu, et al.
Publicado: (2016)

Assessment of Enzyme Inhibition: A Review with Examples from the Development of Monoamine Oxidase and Cholinesterase Inhibitory Drugs
por: Ramsay, Rona R., et al.
Publicado: (2017)

4-Isopropyl-N-phenylcyclohexa-1,3-diene-1-carboxamide
por: Gao, Yan-qing, et al.
Publicado: (2010)

1-Benzoyl-N-phenylcyclopropanecarboxamide
por: Li, Wen-Liang, et al.
Publicado: (2008)

Monoamine Oxidase-A Occupancy by Moclobemide and Phenelzine: Implications for the Development of Monoamine Oxidase Inhibitors
por: Chiuccariello, Lina, et al.
Publicado: (2015)

Development of Halogenated-Chalcones Bearing with Dimethoxy Phenyl Head as Monoamine Oxidase-B Inhibitors
por: Rehuman, Nisha Abdul, et al.
Publicado: (2022)

ABUSE OF MONOAMINE OXIDASE INHIBITORS
por: Ananth, Jambur, et al.
Publicado: (1995)

(3S,4S)-1-Benzylpyrrolidine-3,4-diol
por: Lu, Li-Hua, et al.
Publicado: (2010)

Synthesis and Evaluation of Novel S-alkyl Phthalimide- and S-benzyl-oxadiazole-quinoline Hybrids as Inhibitors of Monoamine Oxidase and Acetylcholinesterase
por: Khan, Bilal Ahmad, et al.
Publicado: (2022)

1-Benzyl-3-phenylimidazolium hexafluorophosphate
por: Jiang, Ping
Publicado: (2009)

Neuroprotective Function of Rasagiline and Selegiline, Inhibitors of Type B Monoamine Oxidase, and Role of Monoamine Oxidases in Synucleinopathies
por: Naoi, Makoto, et al.
Publicado: (2022)

Amphetamine Derivatives as Monoamine Oxidase Inhibitors
por: Reyes-Parada, Miguel, et al.
Publicado: (2020)

Parameters for Irreversible Inactivation of Monoamine Oxidase
por: Ramsay, Rona R., et al.
Publicado: (2020)

N-Phenylmorpholine-4-carboxamide
por: Meng, Shuang-Ming, et al.
Publicado: (2010)

Diclofenac derivatives as concomitant inhibitors of cholinesterase, monoamine oxidase, cyclooxygenase-2 and 5-lipoxygenase for the treatment of Alzheimer's disease: synthesis, pharmacology, toxicity and docking studies
por: Javed, Muhammad Aamir, et al.
Publicado: (2022)

An efficient method to access spiro pseudoindoxyl ketones: evaluation of indoxyl and their N-benzylated derivatives for inhibition of the activity of monoamine oxidases
por: Perumal, Karuppaiah, et al.
Publicado: (2023)

The evaluation of 1-tetralone and 4-chromanone derivatives as inhibitors of monoamine oxidase
por: Cloete, Stephanus J., et al.
Publicado: (2020)

N,N-Dimethyl-3-phenylisoxazole-5-carboxamide
por: Wang, Li, et al.
Publicado: (2013)

N′-(3,4-Dihydroxybenzylidene)acetohydrazide
por: Li, Wei-Wei, et al.
Publicado: (2009)

3-(1-Naphthyl)-N-phenyloxirane-2-carboxamide
por: Chen, Lian-Mei, et al.
Publicado: (2009)

(E)-N′-(4-Bromobenzylidene)-3,4-dihydroxybenzohydrazide monohydrate
por: Zhao, Dan-Yu, et al.
Publicado: (2009)

Design, synthesis, and pharmacological evaluation of 2-amino-5-nitrothiazole derived semicarbazones as dual inhibitors of monoamine oxidase and cholinesterase: effect of the size of aryl binding site
por: Tripathi, Rati K. P., et al.
Publicado: (2017)

Design, Synthesis, and Bioevaluation of Indole Core Containing 2-Arylidine Derivatives of Thiazolopyrimidine as Multitarget Inhibitors of Cholinesterases and Monoamine Oxidase A/B for the Treatment of Alzheimer Disease
por: Shahid Nadeem, Muhammad, et al.
Publicado: (2022)

Crystal structure of 1-benzyl-4-formyl-1H-pyrrole-3-carboxamide
por: Zhong, Qi-Di, et al.
Publicado: (2016)

3-Coumaranone derivatives as inhibitors of monoamine oxidase
por: Van Dyk, Adriaan S, et al.
Publicado: (2015)

Monoamine Oxidase B in Renal Cell Carcinoma
por: Hodorová, Ingrid, et al.
Publicado: (2018)

Cardiac monoamine oxidases: at the heart of mitochondrial dysfunction
por: Mialet-Perez, Jeanne, et al.
Publicado: (2020)

Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B
por: Elkamhawy, Ahmed, et al.
Publicado: (2020)

Subnanomolar indazole-5-carboxamide inhibitors of monoamine oxidase B (MAO-B) continued: indications of iron binding, experimental evidence for optimised solubility and brain penetration
por: Tzvetkov, Nikolay T., et al.
Publicado: (2017)

3-Aryl-1-phenyl-1H-pyrazole derivatives as new multitarget directed ligands for the treatment of Alzheimer's disease, with acetylcholinesterase and monoamine oxidase inhibitory properties
por: Kumar, Ashwani, et al.
Publicado: (2013)

N-(Phenylsulfonyl)naphtho[2,1-b]furan-1-carboxamide
por: Shetprakash, M., et al.
Publicado: (2011)

Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids
por: Bautista-Aguilera, Oscar M, et al.
Publicado: (2014)

Selectivity of Dietary Phenolics for Inhibition of Human Monoamine Oxidases A and B
por: Zhang, Zhenxian, et al.
Publicado: (2019)

1-Benzyl-2-phenyl-1H-benzimidazole
por: Kong, Lingqian
Publicado: (2009)

A second monoclinic polymorph of 1-benzyl-N-methyl-1H-pyrrole-2-carboxamide
por: Wang, Chang Jun, et al.
Publicado: (2011)

1-(4-Bromobenzoyl)-2-phenylpyrrolidine-2-carboxamide
por: Tamazyan, Rafael, et al.
Publicado: (2008)

Activity of (1-benzyl-4-triazolyl)-indole-2-carboxamides against Toxoplasma gondii and Cryptosporidium parvum
por: Khan, Shahbaz M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9fs35vguqu2kcoc0t8sbssefep