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Circulating MicroRNAs as Specific Biomarkers in Atrial Fibrillation: A Meta-Analysis

Atrial fibrillation (AF) is the most frequently occurring supraventricular arrhythmia. Although microRNAs (miRNAs) have been associated with AF pathogenesis, standard protocols for quantifying and selecting specific miRNAs for clinical use as biomarkers should be optimized. In this study, we evaluat...

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Autores principales: Menezes Junior, Antônio da Silva, Ferreira, Lara Cristina, Barbosa, Laura Júlia Valentim, Silva, Daniela de Melo e, Saddi, Vera Aparecida, Silva, Antonio Márcio Teodoro Cordeiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967089/
https://www.ncbi.nlm.nih.gov/pubmed/36827546
http://dx.doi.org/10.3390/ncrna9010013
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author Menezes Junior, Antônio da Silva
Ferreira, Lara Cristina
Barbosa, Laura Júlia Valentim
Silva, Daniela de Melo e
Saddi, Vera Aparecida
Silva, Antonio Márcio Teodoro Cordeiro
author_facet Menezes Junior, Antônio da Silva
Ferreira, Lara Cristina
Barbosa, Laura Júlia Valentim
Silva, Daniela de Melo e
Saddi, Vera Aparecida
Silva, Antonio Márcio Teodoro Cordeiro
author_sort Menezes Junior, Antônio da Silva
collection PubMed
description Atrial fibrillation (AF) is the most frequently occurring supraventricular arrhythmia. Although microRNAs (miRNAs) have been associated with AF pathogenesis, standard protocols for quantifying and selecting specific miRNAs for clinical use as biomarkers should be optimized. In this study, we evaluated the clinical application of miRNAs as biomarkers for the prognosis and diagnosis of AF. Literature searches were conducted on PubMed, Cochrane Library, and EMBASE. We included prospective or retrospective observational studies that had been published as of 14 February 2022; our main objective was to analyze the relationship between circulating miRNAs and AF. The data were extracted using the descriptors “Atrial fibrillation AND miRNA”, “Atrial fibrillation AND diagnostic AND miRNA”, and “Atrial fibrillation AND prognosis AND miRNA”. No filters were applied for period delimitation, type of publication, or language. Studies using samples isolated from blood plasma and TaqMan and RT-qPCR for detecting and quantifying miRNAs were selected, and those that used atrial tissue samples were excluded. We identified 272 articles and excluded 102 duplicated articles. Two authors independently read the titles and abstracts of 170 out of 272 articles and selected 56 potential articles, 6 of which were selected for final review. Our analysis revealed a significant association between AF and miR-4798 [OR = 1.90 (95% CI 1.45–2.47)], AF and miRNA-133a [2.77 (2.73–2.82)], AF and miRNA-150 [3.77 (1.50–9.46); I(2) = 70%], AF and miRNA-21 [2.23 (1.20–4.17); I(2) = 99%], AF and hsa-miRNA4443 [2.32 (2.20–2.44)], and AF and miR-20a-5p [3.67 (1.42–9.49)]. The association between miRNAs and AF showed an OR of 2.51 [95% CI 1.99–3.16; I(2) = 99%]. Our meta-analysis demonstrated that circulating miRNAs are potential biomarkers of AF, as they exhibit stable expression post–sample collection. In addition to regulating cellular processes, such as proliferation, differentiation, development, and cell death, miRNAs were found to be linked to arrhythmia development.
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spelling pubmed-99670892023-02-26 Circulating MicroRNAs as Specific Biomarkers in Atrial Fibrillation: A Meta-Analysis Menezes Junior, Antônio da Silva Ferreira, Lara Cristina Barbosa, Laura Júlia Valentim Silva, Daniela de Melo e Saddi, Vera Aparecida Silva, Antonio Márcio Teodoro Cordeiro Noncoding RNA Systematic Review Atrial fibrillation (AF) is the most frequently occurring supraventricular arrhythmia. Although microRNAs (miRNAs) have been associated with AF pathogenesis, standard protocols for quantifying and selecting specific miRNAs for clinical use as biomarkers should be optimized. In this study, we evaluated the clinical application of miRNAs as biomarkers for the prognosis and diagnosis of AF. Literature searches were conducted on PubMed, Cochrane Library, and EMBASE. We included prospective or retrospective observational studies that had been published as of 14 February 2022; our main objective was to analyze the relationship between circulating miRNAs and AF. The data were extracted using the descriptors “Atrial fibrillation AND miRNA”, “Atrial fibrillation AND diagnostic AND miRNA”, and “Atrial fibrillation AND prognosis AND miRNA”. No filters were applied for period delimitation, type of publication, or language. Studies using samples isolated from blood plasma and TaqMan and RT-qPCR for detecting and quantifying miRNAs were selected, and those that used atrial tissue samples were excluded. We identified 272 articles and excluded 102 duplicated articles. Two authors independently read the titles and abstracts of 170 out of 272 articles and selected 56 potential articles, 6 of which were selected for final review. Our analysis revealed a significant association between AF and miR-4798 [OR = 1.90 (95% CI 1.45–2.47)], AF and miRNA-133a [2.77 (2.73–2.82)], AF and miRNA-150 [3.77 (1.50–9.46); I(2) = 70%], AF and miRNA-21 [2.23 (1.20–4.17); I(2) = 99%], AF and hsa-miRNA4443 [2.32 (2.20–2.44)], and AF and miR-20a-5p [3.67 (1.42–9.49)]. The association between miRNAs and AF showed an OR of 2.51 [95% CI 1.99–3.16; I(2) = 99%]. Our meta-analysis demonstrated that circulating miRNAs are potential biomarkers of AF, as they exhibit stable expression post–sample collection. In addition to regulating cellular processes, such as proliferation, differentiation, development, and cell death, miRNAs were found to be linked to arrhythmia development. MDPI 2023-02-09 /pmc/articles/PMC9967089/ /pubmed/36827546 http://dx.doi.org/10.3390/ncrna9010013 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Menezes Junior, Antônio da Silva
Ferreira, Lara Cristina
Barbosa, Laura Júlia Valentim
Silva, Daniela de Melo e
Saddi, Vera Aparecida
Silva, Antonio Márcio Teodoro Cordeiro
Circulating MicroRNAs as Specific Biomarkers in Atrial Fibrillation: A Meta-Analysis
title Circulating MicroRNAs as Specific Biomarkers in Atrial Fibrillation: A Meta-Analysis
title_full Circulating MicroRNAs as Specific Biomarkers in Atrial Fibrillation: A Meta-Analysis
title_fullStr Circulating MicroRNAs as Specific Biomarkers in Atrial Fibrillation: A Meta-Analysis
title_full_unstemmed Circulating MicroRNAs as Specific Biomarkers in Atrial Fibrillation: A Meta-Analysis
title_short Circulating MicroRNAs as Specific Biomarkers in Atrial Fibrillation: A Meta-Analysis
title_sort circulating micrornas as specific biomarkers in atrial fibrillation: a meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967089/
https://www.ncbi.nlm.nih.gov/pubmed/36827546
http://dx.doi.org/10.3390/ncrna9010013
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