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Design of Functional RGD Peptide-Based Biomaterials for Tissue Engineering

Tissue engineering (TE) is a rapidly expanding field aimed at restoring or replacing damaged tissues. In spite of significant advancements, the implementation of TE technologies requires the development of novel, highly biocompatible three-dimensional tissue structures. In this regard, the use of pe...

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Autores principales: Kumar, Vijay Bhooshan, Tiwari, Om Shanker, Finkelstein-Zuta, Gal, Rencus-Lazar, Sigal, Gazit, Ehud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967156/
https://www.ncbi.nlm.nih.gov/pubmed/36839667
http://dx.doi.org/10.3390/pharmaceutics15020345
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author Kumar, Vijay Bhooshan
Tiwari, Om Shanker
Finkelstein-Zuta, Gal
Rencus-Lazar, Sigal
Gazit, Ehud
author_facet Kumar, Vijay Bhooshan
Tiwari, Om Shanker
Finkelstein-Zuta, Gal
Rencus-Lazar, Sigal
Gazit, Ehud
author_sort Kumar, Vijay Bhooshan
collection PubMed
description Tissue engineering (TE) is a rapidly expanding field aimed at restoring or replacing damaged tissues. In spite of significant advancements, the implementation of TE technologies requires the development of novel, highly biocompatible three-dimensional tissue structures. In this regard, the use of peptide self-assembly is an effective method for developing various tissue structures and surface functionalities. Specifically, the arginine–glycine–aspartic acid (RGD) family of peptides is known to be the most prominent ligand for extracellular integrin receptors. Due to their specific expression patterns in various human tissues and their tight association with various pathophysiological conditions, RGD peptides are suitable targets for tissue regeneration and treatment as well as organ replacement. Therefore, RGD-based ligands have been widely used in biomedical research. This review article summarizes the progress made in the application of RGD for tissue and organ development. Furthermore, we examine the effect of RGD peptide structure and sequence on the efficacy of TE in clinical and preclinical studies. Additionally, we outline the recent advancement in the use of RGD functionalized biomaterials for the regeneration of various tissues, including corneal repair, artificial neovascularization, and bone TE.
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spelling pubmed-99671562023-02-26 Design of Functional RGD Peptide-Based Biomaterials for Tissue Engineering Kumar, Vijay Bhooshan Tiwari, Om Shanker Finkelstein-Zuta, Gal Rencus-Lazar, Sigal Gazit, Ehud Pharmaceutics Review Tissue engineering (TE) is a rapidly expanding field aimed at restoring or replacing damaged tissues. In spite of significant advancements, the implementation of TE technologies requires the development of novel, highly biocompatible three-dimensional tissue structures. In this regard, the use of peptide self-assembly is an effective method for developing various tissue structures and surface functionalities. Specifically, the arginine–glycine–aspartic acid (RGD) family of peptides is known to be the most prominent ligand for extracellular integrin receptors. Due to their specific expression patterns in various human tissues and their tight association with various pathophysiological conditions, RGD peptides are suitable targets for tissue regeneration and treatment as well as organ replacement. Therefore, RGD-based ligands have been widely used in biomedical research. This review article summarizes the progress made in the application of RGD for tissue and organ development. Furthermore, we examine the effect of RGD peptide structure and sequence on the efficacy of TE in clinical and preclinical studies. Additionally, we outline the recent advancement in the use of RGD functionalized biomaterials for the regeneration of various tissues, including corneal repair, artificial neovascularization, and bone TE. MDPI 2023-01-19 /pmc/articles/PMC9967156/ /pubmed/36839667 http://dx.doi.org/10.3390/pharmaceutics15020345 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kumar, Vijay Bhooshan
Tiwari, Om Shanker
Finkelstein-Zuta, Gal
Rencus-Lazar, Sigal
Gazit, Ehud
Design of Functional RGD Peptide-Based Biomaterials for Tissue Engineering
title Design of Functional RGD Peptide-Based Biomaterials for Tissue Engineering
title_full Design of Functional RGD Peptide-Based Biomaterials for Tissue Engineering
title_fullStr Design of Functional RGD Peptide-Based Biomaterials for Tissue Engineering
title_full_unstemmed Design of Functional RGD Peptide-Based Biomaterials for Tissue Engineering
title_short Design of Functional RGD Peptide-Based Biomaterials for Tissue Engineering
title_sort design of functional rgd peptide-based biomaterials for tissue engineering
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967156/
https://www.ncbi.nlm.nih.gov/pubmed/36839667
http://dx.doi.org/10.3390/pharmaceutics15020345
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