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A Novel Hybridization LC-MS/MS Methodology for Quantification of siRNA in Plasma, CSF and Tissue Samples

Therapeutic oligonucleotides, such as antisense oligonucleotide (ASO) and small interfering RNA (siRNA), are a new class of therapeutics rapidly growing in drug discovery and development. A sensitive and reliable method to quantify oligonucleotides in biological samples is critical to study their ph...

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Detalles Bibliográficos
Autores principales:	Yuan, Long, Dupuis, Jean-François, Mekhssian, Kevork
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967190/ https://www.ncbi.nlm.nih.gov/pubmed/36838605 http://dx.doi.org/10.3390/molecules28041618

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