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Neurovascular Coupling in Hypertension Is Impaired by IL-17A through Oxidative Stress

Hypertension, a multifactorial chronic inflammatory condition, is an important risk factor for neurovascular and neurodegenerative diseases, including stroke and Alzheimer’s disease. These diseases have been associated with higher concentrations of circulating interleukin (IL)-17A. However, the poss...

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Autores principales: Youwakim, Jessica, Vallerand, Diane, Girouard, Helene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967204/
https://www.ncbi.nlm.nih.gov/pubmed/36835372
http://dx.doi.org/10.3390/ijms24043959
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author Youwakim, Jessica
Vallerand, Diane
Girouard, Helene
author_facet Youwakim, Jessica
Vallerand, Diane
Girouard, Helene
author_sort Youwakim, Jessica
collection PubMed
description Hypertension, a multifactorial chronic inflammatory condition, is an important risk factor for neurovascular and neurodegenerative diseases, including stroke and Alzheimer’s disease. These diseases have been associated with higher concentrations of circulating interleukin (IL)-17A. However, the possible role that IL-17A plays in linking hypertension with neurodegenerative diseases remains to be established. Cerebral blood flow regulation may be the crossroads of these conditions because regulating mechanisms may be altered in hypertension, including neurovascular coupling (NVC), known to participate in the pathogenesis of stroke and Alzheimer’s disease. In the present study, the role of IL-17A on NVC impairment induced by angiotensin (Ang) II in the context of hypertension was examined. Neutralization of IL-17A or specific inhibition of its receptor prevents the NVC impairment (p < 0.05) and cerebral superoxide anion production (p < 0.05) induced by Ang II. Chronic administration of IL-17A impairs NVC (p < 0.05) and increases superoxide anion production. Both effects were prevented with Tempol and NADPH oxidase 2 gene deletion. These findings suggest that IL-17A, through superoxide anion production, is an important mediator of cerebrovascular dysregulation induced by Ang II. This pathway is thus a putative therapeutic target to restore cerebrovascular regulation in hypertension.
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spelling pubmed-99672042023-02-26 Neurovascular Coupling in Hypertension Is Impaired by IL-17A through Oxidative Stress Youwakim, Jessica Vallerand, Diane Girouard, Helene Int J Mol Sci Article Hypertension, a multifactorial chronic inflammatory condition, is an important risk factor for neurovascular and neurodegenerative diseases, including stroke and Alzheimer’s disease. These diseases have been associated with higher concentrations of circulating interleukin (IL)-17A. However, the possible role that IL-17A plays in linking hypertension with neurodegenerative diseases remains to be established. Cerebral blood flow regulation may be the crossroads of these conditions because regulating mechanisms may be altered in hypertension, including neurovascular coupling (NVC), known to participate in the pathogenesis of stroke and Alzheimer’s disease. In the present study, the role of IL-17A on NVC impairment induced by angiotensin (Ang) II in the context of hypertension was examined. Neutralization of IL-17A or specific inhibition of its receptor prevents the NVC impairment (p < 0.05) and cerebral superoxide anion production (p < 0.05) induced by Ang II. Chronic administration of IL-17A impairs NVC (p < 0.05) and increases superoxide anion production. Both effects were prevented with Tempol and NADPH oxidase 2 gene deletion. These findings suggest that IL-17A, through superoxide anion production, is an important mediator of cerebrovascular dysregulation induced by Ang II. This pathway is thus a putative therapeutic target to restore cerebrovascular regulation in hypertension. MDPI 2023-02-16 /pmc/articles/PMC9967204/ /pubmed/36835372 http://dx.doi.org/10.3390/ijms24043959 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Youwakim, Jessica
Vallerand, Diane
Girouard, Helene
Neurovascular Coupling in Hypertension Is Impaired by IL-17A through Oxidative Stress
title Neurovascular Coupling in Hypertension Is Impaired by IL-17A through Oxidative Stress
title_full Neurovascular Coupling in Hypertension Is Impaired by IL-17A through Oxidative Stress
title_fullStr Neurovascular Coupling in Hypertension Is Impaired by IL-17A through Oxidative Stress
title_full_unstemmed Neurovascular Coupling in Hypertension Is Impaired by IL-17A through Oxidative Stress
title_short Neurovascular Coupling in Hypertension Is Impaired by IL-17A through Oxidative Stress
title_sort neurovascular coupling in hypertension is impaired by il-17a through oxidative stress
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967204/
https://www.ncbi.nlm.nih.gov/pubmed/36835372
http://dx.doi.org/10.3390/ijms24043959
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