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Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin

Ergothioneine, a sulfur-containing micromolecular histidine derivative, has attracted increasing attention from scholars since it was confirmed in the human body. In the human body, ergothioneine is transported and accumulated specifically through OCTN-1, especially in the mitochondria and nucleus,...

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Autores principales: Liu, Hui-Min, Tang, Wei, Wang, Xiao-Yi, Jiang, Jing-Jing, Zhang, Wei, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967237/
https://www.ncbi.nlm.nih.gov/pubmed/36838636
http://dx.doi.org/10.3390/molecules28041648
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author Liu, Hui-Min
Tang, Wei
Wang, Xiao-Yi
Jiang, Jing-Jing
Zhang, Wei
Wang, Wei
author_facet Liu, Hui-Min
Tang, Wei
Wang, Xiao-Yi
Jiang, Jing-Jing
Zhang, Wei
Wang, Wei
author_sort Liu, Hui-Min
collection PubMed
description Ergothioneine, a sulfur-containing micromolecular histidine derivative, has attracted increasing attention from scholars since it was confirmed in the human body. In the human body, ergothioneine is transported and accumulated specifically through OCTN-1, especially in the mitochondria and nucleus, suggesting that it can target damaged cells and tissues as an antioxidant. It shows excellent antioxidant, anti-inflammatory effects, and anti-aging properties, and inhibits melanin production. It is a mega antioxidant that may participate in the antioxidant network system and promote the reducing glutathione regeneration cycle. This review summarizes studies on the antioxidant effects of ergothioneine on various free radicals in vitro to date and systematically introduces its biological activities and potential mechanisms, mostly in dermatology. Additionally, the application of ergothioneine in cosmetics is briefly summarized. Lastly, we propose some problems that require solutions to understand the mechanism of action of ergothioneine. We believe that ergothioneine has good prospects in the food and cosmetics industries, and can thus meet some needs of the health and beauty industry.
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spelling pubmed-99672372023-02-26 Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin Liu, Hui-Min Tang, Wei Wang, Xiao-Yi Jiang, Jing-Jing Zhang, Wei Wang, Wei Molecules Review Ergothioneine, a sulfur-containing micromolecular histidine derivative, has attracted increasing attention from scholars since it was confirmed in the human body. In the human body, ergothioneine is transported and accumulated specifically through OCTN-1, especially in the mitochondria and nucleus, suggesting that it can target damaged cells and tissues as an antioxidant. It shows excellent antioxidant, anti-inflammatory effects, and anti-aging properties, and inhibits melanin production. It is a mega antioxidant that may participate in the antioxidant network system and promote the reducing glutathione regeneration cycle. This review summarizes studies on the antioxidant effects of ergothioneine on various free radicals in vitro to date and systematically introduces its biological activities and potential mechanisms, mostly in dermatology. Additionally, the application of ergothioneine in cosmetics is briefly summarized. Lastly, we propose some problems that require solutions to understand the mechanism of action of ergothioneine. We believe that ergothioneine has good prospects in the food and cosmetics industries, and can thus meet some needs of the health and beauty industry. MDPI 2023-02-08 /pmc/articles/PMC9967237/ /pubmed/36838636 http://dx.doi.org/10.3390/molecules28041648 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Hui-Min
Tang, Wei
Wang, Xiao-Yi
Jiang, Jing-Jing
Zhang, Wei
Wang, Wei
Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin
title Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin
title_full Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin
title_fullStr Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin
title_full_unstemmed Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin
title_short Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin
title_sort safe and effective antioxidant: the biological mechanism and potential pathways of ergothioneine in the skin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967237/
https://www.ncbi.nlm.nih.gov/pubmed/36838636
http://dx.doi.org/10.3390/molecules28041648
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