Cargando…
Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin
Ergothioneine, a sulfur-containing micromolecular histidine derivative, has attracted increasing attention from scholars since it was confirmed in the human body. In the human body, ergothioneine is transported and accumulated specifically through OCTN-1, especially in the mitochondria and nucleus,...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967237/ https://www.ncbi.nlm.nih.gov/pubmed/36838636 http://dx.doi.org/10.3390/molecules28041648 |
_version_ | 1784897214459412480 |
---|---|
author | Liu, Hui-Min Tang, Wei Wang, Xiao-Yi Jiang, Jing-Jing Zhang, Wei Wang, Wei |
author_facet | Liu, Hui-Min Tang, Wei Wang, Xiao-Yi Jiang, Jing-Jing Zhang, Wei Wang, Wei |
author_sort | Liu, Hui-Min |
collection | PubMed |
description | Ergothioneine, a sulfur-containing micromolecular histidine derivative, has attracted increasing attention from scholars since it was confirmed in the human body. In the human body, ergothioneine is transported and accumulated specifically through OCTN-1, especially in the mitochondria and nucleus, suggesting that it can target damaged cells and tissues as an antioxidant. It shows excellent antioxidant, anti-inflammatory effects, and anti-aging properties, and inhibits melanin production. It is a mega antioxidant that may participate in the antioxidant network system and promote the reducing glutathione regeneration cycle. This review summarizes studies on the antioxidant effects of ergothioneine on various free radicals in vitro to date and systematically introduces its biological activities and potential mechanisms, mostly in dermatology. Additionally, the application of ergothioneine in cosmetics is briefly summarized. Lastly, we propose some problems that require solutions to understand the mechanism of action of ergothioneine. We believe that ergothioneine has good prospects in the food and cosmetics industries, and can thus meet some needs of the health and beauty industry. |
format | Online Article Text |
id | pubmed-9967237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99672372023-02-26 Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin Liu, Hui-Min Tang, Wei Wang, Xiao-Yi Jiang, Jing-Jing Zhang, Wei Wang, Wei Molecules Review Ergothioneine, a sulfur-containing micromolecular histidine derivative, has attracted increasing attention from scholars since it was confirmed in the human body. In the human body, ergothioneine is transported and accumulated specifically through OCTN-1, especially in the mitochondria and nucleus, suggesting that it can target damaged cells and tissues as an antioxidant. It shows excellent antioxidant, anti-inflammatory effects, and anti-aging properties, and inhibits melanin production. It is a mega antioxidant that may participate in the antioxidant network system and promote the reducing glutathione regeneration cycle. This review summarizes studies on the antioxidant effects of ergothioneine on various free radicals in vitro to date and systematically introduces its biological activities and potential mechanisms, mostly in dermatology. Additionally, the application of ergothioneine in cosmetics is briefly summarized. Lastly, we propose some problems that require solutions to understand the mechanism of action of ergothioneine. We believe that ergothioneine has good prospects in the food and cosmetics industries, and can thus meet some needs of the health and beauty industry. MDPI 2023-02-08 /pmc/articles/PMC9967237/ /pubmed/36838636 http://dx.doi.org/10.3390/molecules28041648 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Liu, Hui-Min Tang, Wei Wang, Xiao-Yi Jiang, Jing-Jing Zhang, Wei Wang, Wei Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin |
title | Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin |
title_full | Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin |
title_fullStr | Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin |
title_full_unstemmed | Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin |
title_short | Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin |
title_sort | safe and effective antioxidant: the biological mechanism and potential pathways of ergothioneine in the skin |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967237/ https://www.ncbi.nlm.nih.gov/pubmed/36838636 http://dx.doi.org/10.3390/molecules28041648 |
work_keys_str_mv | AT liuhuimin safeandeffectiveantioxidantthebiologicalmechanismandpotentialpathwaysofergothioneineintheskin AT tangwei safeandeffectiveantioxidantthebiologicalmechanismandpotentialpathwaysofergothioneineintheskin AT wangxiaoyi safeandeffectiveantioxidantthebiologicalmechanismandpotentialpathwaysofergothioneineintheskin AT jiangjingjing safeandeffectiveantioxidantthebiologicalmechanismandpotentialpathwaysofergothioneineintheskin AT zhangwei safeandeffectiveantioxidantthebiologicalmechanismandpotentialpathwaysofergothioneineintheskin AT wangwei safeandeffectiveantioxidantthebiologicalmechanismandpotentialpathwaysofergothioneineintheskin |