Cargando…

Impact of Body Composition and Sarcopenia on Mortality in Chronic Obstructive Pulmonary Disease Patients

Background: Patients with chronic obstructive pulmonary disease (COPD) have alterations in body composition, such as low cell integrity, body cell mass, and disturbances in water distribution evidenced by higher impedance ratio (IR), low phase angle (PhA), as well as low strength, low muscle mass, a...

Descripción completa

Detalles Bibliográficos
Autores principales: Gómez-Martínez, Manuel, Rodríguez-García, Wendy, González-Islas, Dulce, Orea-Tejeda, Arturo, Keirns-Davis, Candace, Salgado-Fernández, Fernanda, Hernández-López, Samantha, Jiménez-Valentín, Angelia, Ríos-Pereda, Alejandra Vanessa, Márquez-Cordero, Juan Carlos, Salvatierra-Escobar, Mariana, López-Vásquez, Iris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967244/
https://www.ncbi.nlm.nih.gov/pubmed/36835862
http://dx.doi.org/10.3390/jcm12041321
_version_ 1784897216118259712
author Gómez-Martínez, Manuel
Rodríguez-García, Wendy
González-Islas, Dulce
Orea-Tejeda, Arturo
Keirns-Davis, Candace
Salgado-Fernández, Fernanda
Hernández-López, Samantha
Jiménez-Valentín, Angelia
Ríos-Pereda, Alejandra Vanessa
Márquez-Cordero, Juan Carlos
Salvatierra-Escobar, Mariana
López-Vásquez, Iris
author_facet Gómez-Martínez, Manuel
Rodríguez-García, Wendy
González-Islas, Dulce
Orea-Tejeda, Arturo
Keirns-Davis, Candace
Salgado-Fernández, Fernanda
Hernández-López, Samantha
Jiménez-Valentín, Angelia
Ríos-Pereda, Alejandra Vanessa
Márquez-Cordero, Juan Carlos
Salvatierra-Escobar, Mariana
López-Vásquez, Iris
author_sort Gómez-Martínez, Manuel
collection PubMed
description Background: Patients with chronic obstructive pulmonary disease (COPD) have alterations in body composition, such as low cell integrity, body cell mass, and disturbances in water distribution evidenced by higher impedance ratio (IR), low phase angle (PhA), as well as low strength, low muscle mass, and sarcopenia. Body composition alterations are associated with adverse outcomes. However, according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), the impact of these alterations on mortality in COPD patients is not well-established. Our aims were to evaluate whether low strength, low muscle mass, and sarcopenia impacted mortality in COPD patients. Methods: A prospective cohort study performance was conducted with COPD patients. Patients with cancer, and asthma were excluded. Body composition was assessed by bioelectrical impedance analysis. Low strength and muscle mass, and sarcopenia were defined according to EWGSOP2. Results: 240 patients were evaluated, of whom 32% had sarcopenia. The mean age was 72.32 ± 8.24 years. The factors associated with lower risk of mortality were handgrip strength (HR:0.91, CI 95%; 0.85 to 0.96, p = 0.002), PhA (HR:0.59, CI 95%; 0.37 to 0.94, p = 0.026) and exercise tolerance (HR:0.99, CI 95%; 0.992 to 0.999, p = 0.021), while PhA below the 50th percentile (HR:3.47, CI 95%; 1.45 to 8.29, p = 0.005), low muscle strength (HR:3.49, CI 95%; 1.41 to 8.64, p = 0.007) and sarcopenia (HR:2.10, CI 95%; 1.02 to 4.33, p = 0.022) were associated with a higher risk of mortality. Conclusion: Low PhA, low muscle strength, and sarcopenia are independently associated with poor prognosis in COPD patients.
format Online
Article
Text
id pubmed-9967244
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99672442023-02-26 Impact of Body Composition and Sarcopenia on Mortality in Chronic Obstructive Pulmonary Disease Patients Gómez-Martínez, Manuel Rodríguez-García, Wendy González-Islas, Dulce Orea-Tejeda, Arturo Keirns-Davis, Candace Salgado-Fernández, Fernanda Hernández-López, Samantha Jiménez-Valentín, Angelia Ríos-Pereda, Alejandra Vanessa Márquez-Cordero, Juan Carlos Salvatierra-Escobar, Mariana López-Vásquez, Iris J Clin Med Article Background: Patients with chronic obstructive pulmonary disease (COPD) have alterations in body composition, such as low cell integrity, body cell mass, and disturbances in water distribution evidenced by higher impedance ratio (IR), low phase angle (PhA), as well as low strength, low muscle mass, and sarcopenia. Body composition alterations are associated with adverse outcomes. However, according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), the impact of these alterations on mortality in COPD patients is not well-established. Our aims were to evaluate whether low strength, low muscle mass, and sarcopenia impacted mortality in COPD patients. Methods: A prospective cohort study performance was conducted with COPD patients. Patients with cancer, and asthma were excluded. Body composition was assessed by bioelectrical impedance analysis. Low strength and muscle mass, and sarcopenia were defined according to EWGSOP2. Results: 240 patients were evaluated, of whom 32% had sarcopenia. The mean age was 72.32 ± 8.24 years. The factors associated with lower risk of mortality were handgrip strength (HR:0.91, CI 95%; 0.85 to 0.96, p = 0.002), PhA (HR:0.59, CI 95%; 0.37 to 0.94, p = 0.026) and exercise tolerance (HR:0.99, CI 95%; 0.992 to 0.999, p = 0.021), while PhA below the 50th percentile (HR:3.47, CI 95%; 1.45 to 8.29, p = 0.005), low muscle strength (HR:3.49, CI 95%; 1.41 to 8.64, p = 0.007) and sarcopenia (HR:2.10, CI 95%; 1.02 to 4.33, p = 0.022) were associated with a higher risk of mortality. Conclusion: Low PhA, low muscle strength, and sarcopenia are independently associated with poor prognosis in COPD patients. MDPI 2023-02-07 /pmc/articles/PMC9967244/ /pubmed/36835862 http://dx.doi.org/10.3390/jcm12041321 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gómez-Martínez, Manuel
Rodríguez-García, Wendy
González-Islas, Dulce
Orea-Tejeda, Arturo
Keirns-Davis, Candace
Salgado-Fernández, Fernanda
Hernández-López, Samantha
Jiménez-Valentín, Angelia
Ríos-Pereda, Alejandra Vanessa
Márquez-Cordero, Juan Carlos
Salvatierra-Escobar, Mariana
López-Vásquez, Iris
Impact of Body Composition and Sarcopenia on Mortality in Chronic Obstructive Pulmonary Disease Patients
title Impact of Body Composition and Sarcopenia on Mortality in Chronic Obstructive Pulmonary Disease Patients
title_full Impact of Body Composition and Sarcopenia on Mortality in Chronic Obstructive Pulmonary Disease Patients
title_fullStr Impact of Body Composition and Sarcopenia on Mortality in Chronic Obstructive Pulmonary Disease Patients
title_full_unstemmed Impact of Body Composition and Sarcopenia on Mortality in Chronic Obstructive Pulmonary Disease Patients
title_short Impact of Body Composition and Sarcopenia on Mortality in Chronic Obstructive Pulmonary Disease Patients
title_sort impact of body composition and sarcopenia on mortality in chronic obstructive pulmonary disease patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967244/
https://www.ncbi.nlm.nih.gov/pubmed/36835862
http://dx.doi.org/10.3390/jcm12041321
work_keys_str_mv AT gomezmartinezmanuel impactofbodycompositionandsarcopeniaonmortalityinchronicobstructivepulmonarydiseasepatients
AT rodriguezgarciawendy impactofbodycompositionandsarcopeniaonmortalityinchronicobstructivepulmonarydiseasepatients
AT gonzalezislasdulce impactofbodycompositionandsarcopeniaonmortalityinchronicobstructivepulmonarydiseasepatients
AT oreatejedaarturo impactofbodycompositionandsarcopeniaonmortalityinchronicobstructivepulmonarydiseasepatients
AT keirnsdaviscandace impactofbodycompositionandsarcopeniaonmortalityinchronicobstructivepulmonarydiseasepatients
AT salgadofernandezfernanda impactofbodycompositionandsarcopeniaonmortalityinchronicobstructivepulmonarydiseasepatients
AT hernandezlopezsamantha impactofbodycompositionandsarcopeniaonmortalityinchronicobstructivepulmonarydiseasepatients
AT jimenezvalentinangelia impactofbodycompositionandsarcopeniaonmortalityinchronicobstructivepulmonarydiseasepatients
AT riosperedaalejandravanessa impactofbodycompositionandsarcopeniaonmortalityinchronicobstructivepulmonarydiseasepatients
AT marquezcorderojuancarlos impactofbodycompositionandsarcopeniaonmortalityinchronicobstructivepulmonarydiseasepatients
AT salvatierraescobarmariana impactofbodycompositionandsarcopeniaonmortalityinchronicobstructivepulmonarydiseasepatients
AT lopezvasqueziris impactofbodycompositionandsarcopeniaonmortalityinchronicobstructivepulmonarydiseasepatients