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Influence of Temperature Chronobiology on Stroke Outcome

The circadian system regulates numerous physiological variables, including body temperature. Additionally, a circadian patter has been described in stroke onset. Considering this, we hypothesised that the chronobiology of temperature may have an impact on stroke onset and functional outcomes. We als...

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Autores principales: Alonso-Alonso, Maria Luz, Sampedro-Viana, Ana, Rodríguez-Yáñez, Manuel, López-Dequidt, Iria, Pumar, José M., Mosqueira, Antonio J., Fernández-Rodicio, Sabela, Bazarra-Barreiros, Marcos, Sobrino, Tomás, Campos, Francisco, Castillo, José, Hervella, Pablo, Iglesias-Rey, Ramón
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967262/
https://www.ncbi.nlm.nih.gov/pubmed/36835156
http://dx.doi.org/10.3390/ijms24043746
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author Alonso-Alonso, Maria Luz
Sampedro-Viana, Ana
Rodríguez-Yáñez, Manuel
López-Dequidt, Iria
Pumar, José M.
Mosqueira, Antonio J.
Fernández-Rodicio, Sabela
Bazarra-Barreiros, Marcos
Sobrino, Tomás
Campos, Francisco
Castillo, José
Hervella, Pablo
Iglesias-Rey, Ramón
author_facet Alonso-Alonso, Maria Luz
Sampedro-Viana, Ana
Rodríguez-Yáñez, Manuel
López-Dequidt, Iria
Pumar, José M.
Mosqueira, Antonio J.
Fernández-Rodicio, Sabela
Bazarra-Barreiros, Marcos
Sobrino, Tomás
Campos, Francisco
Castillo, José
Hervella, Pablo
Iglesias-Rey, Ramón
author_sort Alonso-Alonso, Maria Luz
collection PubMed
description The circadian system regulates numerous physiological variables, including body temperature. Additionally, a circadian patter has been described in stroke onset. Considering this, we hypothesised that the chronobiology of temperature may have an impact on stroke onset and functional outcomes. We also studied the variation of blood biomarkers according to stroke onset time. This is a retrospective observational study. Of the patients included, 2763 had a stroke between midnight and 8:00 h; 1571 between 8:00–14:00 h; and 655 between 14:00 h and midnight. Axillary temperature was measured at admission. At this time, blood samples were collected for biomarker analysis (TNF-α, IL-1β, IL-6, IL-10, and glutamate). Temperature was higher in patients admitted from 8:00 h to midnight (p < 0.0001). However, the percentage of poor outcome at 3 months was highest in patients from midnight to 8:00 h (57.7%, p < 0.001). The association between temperature and mortality was highest during night time (OR: 2.79; CI 95%: 2.36–3.28; p < 0.001). These patients exhibited high glutamate (220.2 ± 140.2 µM), IL-6 (32.8 ± 14.3 pg/mL) and low IL-10 (9.7 ± 14.3 pg/mL) levels. Therefore, temperature chronobiology could have a significant impact on stroke onset and functional outcome. Superficial body hyperthermia during sleep seems to be more dangerous than during wakefulness. Further studies will be necessary to confirm our data.
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spelling pubmed-99672622023-02-26 Influence of Temperature Chronobiology on Stroke Outcome Alonso-Alonso, Maria Luz Sampedro-Viana, Ana Rodríguez-Yáñez, Manuel López-Dequidt, Iria Pumar, José M. Mosqueira, Antonio J. Fernández-Rodicio, Sabela Bazarra-Barreiros, Marcos Sobrino, Tomás Campos, Francisco Castillo, José Hervella, Pablo Iglesias-Rey, Ramón Int J Mol Sci Article The circadian system regulates numerous physiological variables, including body temperature. Additionally, a circadian patter has been described in stroke onset. Considering this, we hypothesised that the chronobiology of temperature may have an impact on stroke onset and functional outcomes. We also studied the variation of blood biomarkers according to stroke onset time. This is a retrospective observational study. Of the patients included, 2763 had a stroke between midnight and 8:00 h; 1571 between 8:00–14:00 h; and 655 between 14:00 h and midnight. Axillary temperature was measured at admission. At this time, blood samples were collected for biomarker analysis (TNF-α, IL-1β, IL-6, IL-10, and glutamate). Temperature was higher in patients admitted from 8:00 h to midnight (p < 0.0001). However, the percentage of poor outcome at 3 months was highest in patients from midnight to 8:00 h (57.7%, p < 0.001). The association between temperature and mortality was highest during night time (OR: 2.79; CI 95%: 2.36–3.28; p < 0.001). These patients exhibited high glutamate (220.2 ± 140.2 µM), IL-6 (32.8 ± 14.3 pg/mL) and low IL-10 (9.7 ± 14.3 pg/mL) levels. Therefore, temperature chronobiology could have a significant impact on stroke onset and functional outcome. Superficial body hyperthermia during sleep seems to be more dangerous than during wakefulness. Further studies will be necessary to confirm our data. MDPI 2023-02-13 /pmc/articles/PMC9967262/ /pubmed/36835156 http://dx.doi.org/10.3390/ijms24043746 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alonso-Alonso, Maria Luz
Sampedro-Viana, Ana
Rodríguez-Yáñez, Manuel
López-Dequidt, Iria
Pumar, José M.
Mosqueira, Antonio J.
Fernández-Rodicio, Sabela
Bazarra-Barreiros, Marcos
Sobrino, Tomás
Campos, Francisco
Castillo, José
Hervella, Pablo
Iglesias-Rey, Ramón
Influence of Temperature Chronobiology on Stroke Outcome
title Influence of Temperature Chronobiology on Stroke Outcome
title_full Influence of Temperature Chronobiology on Stroke Outcome
title_fullStr Influence of Temperature Chronobiology on Stroke Outcome
title_full_unstemmed Influence of Temperature Chronobiology on Stroke Outcome
title_short Influence of Temperature Chronobiology on Stroke Outcome
title_sort influence of temperature chronobiology on stroke outcome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967262/
https://www.ncbi.nlm.nih.gov/pubmed/36835156
http://dx.doi.org/10.3390/ijms24043746
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