Cargando…

Interaction of Camptothecin Anticancer Drugs with Ribosomal Proteins L15 and L11: A Molecular Docking Study

The antitumor drug topotecan (TPT) is a potent inhibitor of topoisomerase I, triggering DNA breaks lethal for proliferating cancer cells. The mechanism is common to camptothecins SN38 (the active metabolite of irinotecan) and belotecan (BLT). Recently, TPT was shown to bind the ribosomal protein L15...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bailly, Christian, Vergoten, Gérard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967338/ https://www.ncbi.nlm.nih.gov/pubmed/36838813 http://dx.doi.org/10.3390/molecules28041828

Ejemplares similares

Molecular Docking of Cryptoconcatones to α-Tubulin and Related Pironetin Analogues
por: Vergoten, Gérard, et al.
Publicado: (2023)

Binding of Vialinin A and p-Terphenyl Derivatives to Ubiquitin-Specific Protease 4 (USP4): A Molecular Docking Study
por: Bailly, Christian, et al.
Publicado: (2022)

Anticancer Properties and Mechanism of Action of Oblongifolin C, Guttiferone K and Related Polyprenylated Acylphloroglucinols
por: Bailly, Christian, et al.
Publicado: (2021)

Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?
por: Bailly, Christian, et al.
Publicado: (2020)

Drug Repurposing to Enhance Antitumor Response to PD-1/PD-L1 Immune Checkpoint Inhibitors
por: Thuru, Xavier, et al.
Publicado: (2022)

Interaction of obtusilactone B and related butanolide lactones with the barrier-to-autointegration factor 1 (BAF1). A computational study
por: Bailly, Christian, et al.
Publicado: (2021)

A Potential Off-Target Effect of the Wnt/β-Catenin Inhibitor KYA1797K: PD-L1 Binding and Checkpoint Inhibition
por: Thuru, Xavier, et al.
Publicado: (2023)

Mechanistic insights into dimethyl cardamonin-mediated pharmacological effects: A double control of the AMPK-HMGB1 signaling axis
por: Bailly, Christian, et al.
Publicado: (2020)

In silico analysis of echinocandins binding to the main proteases of coronaviruses PEDV (3CL(pro)) and SARS-CoV-2 (M(pro))
por: Vergoten, Gérard, et al.
Publicado: (2021)

Computational biotechnology guides elucidation of the biosynthesis of the plant anticancer drug camptothecin
por: Stander, Emily Amor, et al.
Publicado: (2021)

Ribosomal Protein L15 is involved in Colon Carcinogenesis
por: Dong, Zhixiong, et al.
Publicado: (2019)

Anticancer Drug Camptothecin Test in 3D Hydrogel Networks with HeLa cells
por: Liang, Jun, et al.
Publicado: (2017)

Camptothecin suppresses NRF2–ARE activity and sensitises hepatocellular carcinoma cells to anticancer drugs
por: Chen, Feng, et al.
Publicado: (2017)

Anticancer activity, phytochemical investigation and molecular docking insights of Citrullus colocynthis (L.) fruits
por: Mandour, Yasmine M., et al.
Publicado: (2023)

Molecular docking and dynamics simulation study of bioactive compounds from Ficus carica L. with important anticancer drug targets
por: Gurung, Arun Bahadur, et al.
Publicado: (2021)

Correction: Camptothecin suppresses NRF2–ARE activity and sensitises hepatocellular carcinoma cells to anticancer drugs
por: Chen, Feng, et al.
Publicado: (2019)

Common chaperone activity in the G-domain of trGTPase protects L11–L12 interaction on the ribosome
por: Zhang, Dandan, et al.
Publicado: (2012)

Study of Interactions of an Anticancer Drug Neratinib With Bovine Serum Albumin: Spectroscopic and Molecular Docking Approach
por: Wani, Tanveer A., et al.
Publicado: (2018)

The transcription factor OpWRKY2 positively regulates the biosynthesis of the anticancer drug camptothecin in Ophiorrhiza pumila
por: Hao, Xiaolong, et al.
Publicado: (2021)

Mechanism of action of glycyrrhizin against Plasmodium falciparum
por: Soeiro, Maria de Nazaré Correia, et al.
Publicado: (2021)

Interaction between the assembly of the ribosomal subunits: Disruption of 40S ribosomal assembly causes accumulation of extra-ribosomal 60S ribosomal protein uL18/L5
por: Rahman, Nusrat, et al.
Publicado: (2020)

Overexpression of ribosomal protein L15 is associated with cell proliferation in gastric cancer
por: Wang, Hui, et al.
Publicado: (2006)

Camptothecin Induces PD-L1 and Immunomodulatory Cytokines in Colon Cancer Cells
por: Bedi, Deepa, et al.
Publicado: (2019)

Principal component and clustering analysis on molecular dynamics data of the ribosomal L11·23S subdomain
por: Wolf, Antje, et al.
Publicado: (2012)

Combretastatin A4-camptothecin micelles as combination therapy for effective anticancer activity
por: Assali, Mohyeddin, et al.
Publicado: (2019)

Discovering and harnessing oxidative enzymes for chemoenzymatic synthesis and diversification of anticancer camptothecin analogues
por: Nguyen, Tuan-Anh M., et al.
Publicado: (2021)

Effect of precursors feeding and media manipulation on production of novel anticancer pro-drug camptothecin from endophytic fungus
por: Amna, Touseef, et al.
Publicado: (2012)

Stealth Liposomes (PEGylated) Containing an Anticancer Drug Camptothecin: In Vitro Characterization and In Vivo Pharmacokinetic and Tissue Distribution Study
por: Sivadasan, Durgaramani, et al.
Publicado: (2022)

An In Silico Study Investigating Camptothecin-Analog Interaction with Human Protein Tyrosine Phosphatase, SHP2 (PTPN11)
por: Bajia, Donald, et al.
Publicado: (2023)

Molecular cloning and characterization of porcine ribosomal protein L21
por: Sun, Wu-Sheng, et al.
Publicado: (2017)

Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates
por: Li, Wei, et al.
Publicado: (2019)

Functional Interaction between Ribosomal Protein L6 and RbgA during Ribosome Assembly
por: Gulati, Megha, et al.
Publicado: (2014)

Camptothecin effectively treats obesity in mice through GDF15 induction
por: Lu, Jun Feng, et al.
Publicado: (2022)

Targeted Gold Nanohybrids Functionalized with Folate-Hydrophobic-Quaternized Pullulan Delivering Camptothecin for Enhancing Hydrophobic Anticancer Drug Efficacy
por: Laksee, Sakchai, et al.
Publicado: (2021)

Trypanosoma brucei L11 Is Essential to Ribosome Biogenesis and Interacts with the Kinetoplastid-Specific Proteins P34 and P37
por: Jaremko, Daniel, et al.
Publicado: (2019)

Preparation of Reduction-Responsive Camptothecin Nanocapsules by Combining Nanoprecipitation and In Situ Polymerization for Anticancer Therapy
por: Song, Xiao-Qing, et al.
Publicado: (2018)

Recent Advances in Improved Anticancer Efficacies of Camptothecin Nano-Formulations: A Systematic Review
por: Ghanbari-Movahed, Maryam, et al.
Publicado: (2021)

Ribosomal Proteins L5 and L11 Cooperatively Inactivate c-Myc via RNA-induced Silencing Complex
por: Liao, Jun-Ming, et al.
Publicado: (2013)

Protective Effects of Kampo Medicines and Baicalin against Intestinal Toxicity of a New Anticancer Camptothecin Derivative, Irinotecan Hydrochloride (CPT‐11), in Rats
por: Takasuna, Kiyoshi, et al.
Publicado: (1995)

In vivo assembling of bacterial ribosomal protein L11 into yeast ribosomes makes the particles sensitive to the prokaryotic specific antibiotic thiostrepton
por: García-Marcos, Alberto, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_89h4m53m772ti950f0jn1dqaj6