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The Effect of Calcium Hydroxide, Triple Antibiotic Paste and Chlorhexidine on Pain in Teeth with Symptomatic Apical Periodontitis: A Randomised Controlled Trial

Background: One of the main reasons for post endodontic pain is the polymicrobial intracanal flora that may survive the initial disinfection. A single antimicrobial agent might not provide adequate disinfection, and an antimicrobial combination such as triple antibiotic paste was tested to achieve t...

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Autores principales: Khan, Asma Munir, Gangoo, Irfana Khursheed Ahmed, Ali, Naila Amir, Khan, Mansoor, Javed, Muhammad Qasim, AlAttas, Mustafa Hussein, Abulhamael, Ayman M., Bahammam, Hammam Ahmed, Alsofi, Loai, Yahya, Rayan Suliman Al
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967357/
https://www.ncbi.nlm.nih.gov/pubmed/36833788
http://dx.doi.org/10.3390/ijerph20043091
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author Khan, Asma Munir
Gangoo, Irfana Khursheed Ahmed
Ali, Naila Amir
Khan, Mansoor
Javed, Muhammad Qasim
AlAttas, Mustafa Hussein
Abulhamael, Ayman M.
Bahammam, Hammam Ahmed
Alsofi, Loai
Yahya, Rayan Suliman Al
author_facet Khan, Asma Munir
Gangoo, Irfana Khursheed Ahmed
Ali, Naila Amir
Khan, Mansoor
Javed, Muhammad Qasim
AlAttas, Mustafa Hussein
Abulhamael, Ayman M.
Bahammam, Hammam Ahmed
Alsofi, Loai
Yahya, Rayan Suliman Al
author_sort Khan, Asma Munir
collection PubMed
description Background: One of the main reasons for post endodontic pain is the polymicrobial intracanal flora that may survive the initial disinfection. A single antimicrobial agent might not provide adequate disinfection, and an antimicrobial combination such as triple antibiotic paste was tested to achieve this goal. Aim: The study aimed to assess the efficacy of three intra-canal medicaments on post root canal preparation pain. Materials and Methods: Eighty patients with single-rooted necrotic teeth and symptomatic apical periodontitis were randomly assigned to four treatment groups (n = 20). Their preoperative pain was recorded on Wong-Baker’s FACES pain rating scale. After chemo-mechanical canal preparation, intracanal medications were applied to the groups (Group 1 (20% calcium hydroxide), Group 2 (2% chlorhexidine), Group 3 (tri-antibiotic paste), Group 4 (no medication (Control group)). Patients were instructed to record pain on the Wong-Baker FACES pain rating scale at 4, 48, 72 and 96 hrs, postoperatively. Pain scores were analyzed using a one-way ANOVA test and Tukey’s post hoc test and, if significant, Dunn’s test was used for pair-wise comparisons. The significance level was set at a p-value ≤ 0.05. Results: Tukey’s post hoc test revealed significantly lower pain scores in Group 3 compared with other groups at all follow up intervals. Dunnett’s test showed significantly lower pain in Group 3 compared with the Control group at 48, 72 and 96 hrs, postoperatively. Conclusions: Triple-antibiotic paste showed effective pain control as an intracanal medication on necrotic teeth with symptomatic apical periodontitis.
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spelling pubmed-99673572023-02-26 The Effect of Calcium Hydroxide, Triple Antibiotic Paste and Chlorhexidine on Pain in Teeth with Symptomatic Apical Periodontitis: A Randomised Controlled Trial Khan, Asma Munir Gangoo, Irfana Khursheed Ahmed Ali, Naila Amir Khan, Mansoor Javed, Muhammad Qasim AlAttas, Mustafa Hussein Abulhamael, Ayman M. Bahammam, Hammam Ahmed Alsofi, Loai Yahya, Rayan Suliman Al Int J Environ Res Public Health Article Background: One of the main reasons for post endodontic pain is the polymicrobial intracanal flora that may survive the initial disinfection. A single antimicrobial agent might not provide adequate disinfection, and an antimicrobial combination such as triple antibiotic paste was tested to achieve this goal. Aim: The study aimed to assess the efficacy of three intra-canal medicaments on post root canal preparation pain. Materials and Methods: Eighty patients with single-rooted necrotic teeth and symptomatic apical periodontitis were randomly assigned to four treatment groups (n = 20). Their preoperative pain was recorded on Wong-Baker’s FACES pain rating scale. After chemo-mechanical canal preparation, intracanal medications were applied to the groups (Group 1 (20% calcium hydroxide), Group 2 (2% chlorhexidine), Group 3 (tri-antibiotic paste), Group 4 (no medication (Control group)). Patients were instructed to record pain on the Wong-Baker FACES pain rating scale at 4, 48, 72 and 96 hrs, postoperatively. Pain scores were analyzed using a one-way ANOVA test and Tukey’s post hoc test and, if significant, Dunn’s test was used for pair-wise comparisons. The significance level was set at a p-value ≤ 0.05. Results: Tukey’s post hoc test revealed significantly lower pain scores in Group 3 compared with other groups at all follow up intervals. Dunnett’s test showed significantly lower pain in Group 3 compared with the Control group at 48, 72 and 96 hrs, postoperatively. Conclusions: Triple-antibiotic paste showed effective pain control as an intracanal medication on necrotic teeth with symptomatic apical periodontitis. MDPI 2023-02-10 /pmc/articles/PMC9967357/ /pubmed/36833788 http://dx.doi.org/10.3390/ijerph20043091 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Khan, Asma Munir
Gangoo, Irfana Khursheed Ahmed
Ali, Naila Amir
Khan, Mansoor
Javed, Muhammad Qasim
AlAttas, Mustafa Hussein
Abulhamael, Ayman M.
Bahammam, Hammam Ahmed
Alsofi, Loai
Yahya, Rayan Suliman Al
The Effect of Calcium Hydroxide, Triple Antibiotic Paste and Chlorhexidine on Pain in Teeth with Symptomatic Apical Periodontitis: A Randomised Controlled Trial
title The Effect of Calcium Hydroxide, Triple Antibiotic Paste and Chlorhexidine on Pain in Teeth with Symptomatic Apical Periodontitis: A Randomised Controlled Trial
title_full The Effect of Calcium Hydroxide, Triple Antibiotic Paste and Chlorhexidine on Pain in Teeth with Symptomatic Apical Periodontitis: A Randomised Controlled Trial
title_fullStr The Effect of Calcium Hydroxide, Triple Antibiotic Paste and Chlorhexidine on Pain in Teeth with Symptomatic Apical Periodontitis: A Randomised Controlled Trial
title_full_unstemmed The Effect of Calcium Hydroxide, Triple Antibiotic Paste and Chlorhexidine on Pain in Teeth with Symptomatic Apical Periodontitis: A Randomised Controlled Trial
title_short The Effect of Calcium Hydroxide, Triple Antibiotic Paste and Chlorhexidine on Pain in Teeth with Symptomatic Apical Periodontitis: A Randomised Controlled Trial
title_sort effect of calcium hydroxide, triple antibiotic paste and chlorhexidine on pain in teeth with symptomatic apical periodontitis: a randomised controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967357/
https://www.ncbi.nlm.nih.gov/pubmed/36833788
http://dx.doi.org/10.3390/ijerph20043091
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