Reducing GEF-H1 Expression Inhibits Renal Cyst Formation, Inflammation, and Fibrosis via RhoA Signaling in Nephronophthisis

Nephronophthisis (NPHP) is the most prevalent monogenic disease leading to end-stage renal failure in childhood. RhoA activation is involved in NPHP pathogenesis. This study explored the role of the RhoA activator guanine nucleotide exchange factor (GEF)-H1 in NPHP pathogenesis. We analyzed the expr...

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Detalles Bibliográficos
Autores principales: Hu, Qiulei, Lai, Jiayong, Chen, Huamu, Cai, Yong, Yue, Zhihui, Lin, Hongrong, Sun, Liangzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967383/
https://www.ncbi.nlm.nih.gov/pubmed/36834937
http://dx.doi.org/10.3390/ijms24043504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967383/
https://www.ncbi.nlm.nih.gov/pubmed/36834937
http://dx.doi.org/10.3390/ijms24043504

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