Cargando…

Heterogeneity of Ocular Hemodynamic Biomarkers among Open Angle Glaucoma Patients of African and European Descent

This study investigated the heterogeneity of ocular hemodynamic biomarkers in early open angle glaucoma (OAG) patients and healthy controls of African (AD) and European descent (ED). Sixty OAG patients (38 ED, 22 AD) and 65 healthy controls (47 ED, 18 AD) participated in a prospective, cross-section...

Descripción completa

Detalles Bibliográficos
Autores principales: Siesky, Brent, Harris, Alon, Verticchio Vercellin, Alice, Arciero, Julia, Fry, Brendan, Eckert, George, Guidoboni, Giovanna, Oddone, Francesco, Antman, Gal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967448/
https://www.ncbi.nlm.nih.gov/pubmed/36835823
http://dx.doi.org/10.3390/jcm12041287
_version_ 1784897266956369920
author Siesky, Brent
Harris, Alon
Verticchio Vercellin, Alice
Arciero, Julia
Fry, Brendan
Eckert, George
Guidoboni, Giovanna
Oddone, Francesco
Antman, Gal
author_facet Siesky, Brent
Harris, Alon
Verticchio Vercellin, Alice
Arciero, Julia
Fry, Brendan
Eckert, George
Guidoboni, Giovanna
Oddone, Francesco
Antman, Gal
author_sort Siesky, Brent
collection PubMed
description This study investigated the heterogeneity of ocular hemodynamic biomarkers in early open angle glaucoma (OAG) patients and healthy controls of African (AD) and European descent (ED). Sixty OAG patients (38 ED, 22 AD) and 65 healthy controls (47 ED, 18 AD) participated in a prospective, cross-sectional study assessing: intraocular pressure (IOP), blood pressure (BP), ocular perfusion pressure (OPP), visual field (VF) and vascular densities (VD) via optical coherence tomography angiography (OCTA). Comparisons between outcomes were adjusted for age, diabetes status and BP. VF, IOP, BP and OPP were not significantly different between OAG subgroups or controls. Multiple VD biomarkers were significantly lower in OAG patients of ED (p < 0.05) while central macular VD was lower in OAG patients of AD vs. OAG patients of ED (p = 0.024). Macular and parafoveal thickness were significantly lower in AD OAG patients compared to those of ED (p = 0.006–0.049). OAG patients of AD had a negative correlation between IOP and VF index (r = −0.86) while ED patients had a slightly positive relationship (r = 0.26); difference between groups (p < 0.001). Age-adjusted OCTA biomarkers exhibit significant variation in early OAG patients of AD and ED.
format Online
Article
Text
id pubmed-9967448
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99674482023-02-27 Heterogeneity of Ocular Hemodynamic Biomarkers among Open Angle Glaucoma Patients of African and European Descent Siesky, Brent Harris, Alon Verticchio Vercellin, Alice Arciero, Julia Fry, Brendan Eckert, George Guidoboni, Giovanna Oddone, Francesco Antman, Gal J Clin Med Article This study investigated the heterogeneity of ocular hemodynamic biomarkers in early open angle glaucoma (OAG) patients and healthy controls of African (AD) and European descent (ED). Sixty OAG patients (38 ED, 22 AD) and 65 healthy controls (47 ED, 18 AD) participated in a prospective, cross-sectional study assessing: intraocular pressure (IOP), blood pressure (BP), ocular perfusion pressure (OPP), visual field (VF) and vascular densities (VD) via optical coherence tomography angiography (OCTA). Comparisons between outcomes were adjusted for age, diabetes status and BP. VF, IOP, BP and OPP were not significantly different between OAG subgroups or controls. Multiple VD biomarkers were significantly lower in OAG patients of ED (p < 0.05) while central macular VD was lower in OAG patients of AD vs. OAG patients of ED (p = 0.024). Macular and parafoveal thickness were significantly lower in AD OAG patients compared to those of ED (p = 0.006–0.049). OAG patients of AD had a negative correlation between IOP and VF index (r = −0.86) while ED patients had a slightly positive relationship (r = 0.26); difference between groups (p < 0.001). Age-adjusted OCTA biomarkers exhibit significant variation in early OAG patients of AD and ED. MDPI 2023-02-06 /pmc/articles/PMC9967448/ /pubmed/36835823 http://dx.doi.org/10.3390/jcm12041287 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Siesky, Brent
Harris, Alon
Verticchio Vercellin, Alice
Arciero, Julia
Fry, Brendan
Eckert, George
Guidoboni, Giovanna
Oddone, Francesco
Antman, Gal
Heterogeneity of Ocular Hemodynamic Biomarkers among Open Angle Glaucoma Patients of African and European Descent
title Heterogeneity of Ocular Hemodynamic Biomarkers among Open Angle Glaucoma Patients of African and European Descent
title_full Heterogeneity of Ocular Hemodynamic Biomarkers among Open Angle Glaucoma Patients of African and European Descent
title_fullStr Heterogeneity of Ocular Hemodynamic Biomarkers among Open Angle Glaucoma Patients of African and European Descent
title_full_unstemmed Heterogeneity of Ocular Hemodynamic Biomarkers among Open Angle Glaucoma Patients of African and European Descent
title_short Heterogeneity of Ocular Hemodynamic Biomarkers among Open Angle Glaucoma Patients of African and European Descent
title_sort heterogeneity of ocular hemodynamic biomarkers among open angle glaucoma patients of african and european descent
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967448/
https://www.ncbi.nlm.nih.gov/pubmed/36835823
http://dx.doi.org/10.3390/jcm12041287
work_keys_str_mv AT sieskybrent heterogeneityofocularhemodynamicbiomarkersamongopenangleglaucomapatientsofafricanandeuropeandescent
AT harrisalon heterogeneityofocularhemodynamicbiomarkersamongopenangleglaucomapatientsofafricanandeuropeandescent
AT verticchiovercellinalice heterogeneityofocularhemodynamicbiomarkersamongopenangleglaucomapatientsofafricanandeuropeandescent
AT arcierojulia heterogeneityofocularhemodynamicbiomarkersamongopenangleglaucomapatientsofafricanandeuropeandescent
AT frybrendan heterogeneityofocularhemodynamicbiomarkersamongopenangleglaucomapatientsofafricanandeuropeandescent
AT eckertgeorge heterogeneityofocularhemodynamicbiomarkersamongopenangleglaucomapatientsofafricanandeuropeandescent
AT guidobonigiovanna heterogeneityofocularhemodynamicbiomarkersamongopenangleglaucomapatientsofafricanandeuropeandescent
AT oddonefrancesco heterogeneityofocularhemodynamicbiomarkersamongopenangleglaucomapatientsofafricanandeuropeandescent
AT antmangal heterogeneityofocularhemodynamicbiomarkersamongopenangleglaucomapatientsofafricanandeuropeandescent