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Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review

Background: Post-viral syndromes (PVS), including Long COVID, are symptoms sustained from weeks to years following an acute viral infection. Non-pharmacological treatments for these symptoms are poorly understood. This review summarises the evidence for the effectiveness of non-pharmacological treat...

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Autores principales: Chandan, Joht Singh, Brown, Kirsty R., Simms-Williams, Nikita, Bashir, Nasir Z., Camaradou, Jenny, Heining, Dominic, Turner, Grace M., Rivera, Samantha Cruz, Hotham, Richard, Minhas, Sonica, Nirantharakumar, Krishnarajah, Sivan, Manoj, Khunti, Kamlesh, Raindi, Devan, Marwaha, Steven, Hughes, Sarah E., McMullan, Christel, Marshall, Tom, Calvert, Melanie J., Haroon, Shamil, Aiyegbusi, Olalekan Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967466/
https://www.ncbi.nlm.nih.gov/pubmed/36834176
http://dx.doi.org/10.3390/ijerph20043477
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author Chandan, Joht Singh
Brown, Kirsty R.
Simms-Williams, Nikita
Bashir, Nasir Z.
Camaradou, Jenny
Heining, Dominic
Turner, Grace M.
Rivera, Samantha Cruz
Hotham, Richard
Minhas, Sonica
Nirantharakumar, Krishnarajah
Sivan, Manoj
Khunti, Kamlesh
Raindi, Devan
Marwaha, Steven
Hughes, Sarah E.
McMullan, Christel
Marshall, Tom
Calvert, Melanie J.
Haroon, Shamil
Aiyegbusi, Olalekan Lee
author_facet Chandan, Joht Singh
Brown, Kirsty R.
Simms-Williams, Nikita
Bashir, Nasir Z.
Camaradou, Jenny
Heining, Dominic
Turner, Grace M.
Rivera, Samantha Cruz
Hotham, Richard
Minhas, Sonica
Nirantharakumar, Krishnarajah
Sivan, Manoj
Khunti, Kamlesh
Raindi, Devan
Marwaha, Steven
Hughes, Sarah E.
McMullan, Christel
Marshall, Tom
Calvert, Melanie J.
Haroon, Shamil
Aiyegbusi, Olalekan Lee
author_sort Chandan, Joht Singh
collection PubMed
description Background: Post-viral syndromes (PVS), including Long COVID, are symptoms sustained from weeks to years following an acute viral infection. Non-pharmacological treatments for these symptoms are poorly understood. This review summarises the evidence for the effectiveness of non-pharmacological treatments for PVS. Methods: We conducted a systematic review to evaluate the effectiveness of non-pharmacological interventions for PVS, as compared to either standard care, alternative non-pharmacological therapy, or placebo. The outcomes of interest were changes in symptoms, exercise capacity, quality of life (including mental health and wellbeing), and work capability. We searched five databases (Embase, MEDLINE, PsycINFO, CINAHL, MedRxiv) for randomised controlled trials (RCTs) published between 1 January 2001 to 29 October 2021. The relevant outcome data were extracted, the study quality was appraised using the Cochrane risk-of-bias tool, and the findings were synthesised narratively. Findings: Overall, five studies of five different interventions (Pilates, music therapy, telerehabilitation, resistance exercise, neuromodulation) met the inclusion criteria. Aside from music-based intervention, all other selected interventions demonstrated some support in the management of PVS in some patients. Interpretation: In this study, we observed a lack of robust evidence evaluating the non-pharmacological treatments for PVS, including Long COVID. Considering the prevalence of prolonged symptoms following acute viral infections, there is an urgent need for clinical trials evaluating the effectiveness and cost-effectiveness of non-pharmacological treatments for patients with PVS. Registration: The study protocol was registered with PROSPERO [CRD42021282074] in October 2021 and published in BMJ Open in 2022.
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spelling pubmed-99674662023-02-27 Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review Chandan, Joht Singh Brown, Kirsty R. Simms-Williams, Nikita Bashir, Nasir Z. Camaradou, Jenny Heining, Dominic Turner, Grace M. Rivera, Samantha Cruz Hotham, Richard Minhas, Sonica Nirantharakumar, Krishnarajah Sivan, Manoj Khunti, Kamlesh Raindi, Devan Marwaha, Steven Hughes, Sarah E. McMullan, Christel Marshall, Tom Calvert, Melanie J. Haroon, Shamil Aiyegbusi, Olalekan Lee Int J Environ Res Public Health Review Background: Post-viral syndromes (PVS), including Long COVID, are symptoms sustained from weeks to years following an acute viral infection. Non-pharmacological treatments for these symptoms are poorly understood. This review summarises the evidence for the effectiveness of non-pharmacological treatments for PVS. Methods: We conducted a systematic review to evaluate the effectiveness of non-pharmacological interventions for PVS, as compared to either standard care, alternative non-pharmacological therapy, or placebo. The outcomes of interest were changes in symptoms, exercise capacity, quality of life (including mental health and wellbeing), and work capability. We searched five databases (Embase, MEDLINE, PsycINFO, CINAHL, MedRxiv) for randomised controlled trials (RCTs) published between 1 January 2001 to 29 October 2021. The relevant outcome data were extracted, the study quality was appraised using the Cochrane risk-of-bias tool, and the findings were synthesised narratively. Findings: Overall, five studies of five different interventions (Pilates, music therapy, telerehabilitation, resistance exercise, neuromodulation) met the inclusion criteria. Aside from music-based intervention, all other selected interventions demonstrated some support in the management of PVS in some patients. Interpretation: In this study, we observed a lack of robust evidence evaluating the non-pharmacological treatments for PVS, including Long COVID. Considering the prevalence of prolonged symptoms following acute viral infections, there is an urgent need for clinical trials evaluating the effectiveness and cost-effectiveness of non-pharmacological treatments for patients with PVS. Registration: The study protocol was registered with PROSPERO [CRD42021282074] in October 2021 and published in BMJ Open in 2022. MDPI 2023-02-16 /pmc/articles/PMC9967466/ /pubmed/36834176 http://dx.doi.org/10.3390/ijerph20043477 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chandan, Joht Singh
Brown, Kirsty R.
Simms-Williams, Nikita
Bashir, Nasir Z.
Camaradou, Jenny
Heining, Dominic
Turner, Grace M.
Rivera, Samantha Cruz
Hotham, Richard
Minhas, Sonica
Nirantharakumar, Krishnarajah
Sivan, Manoj
Khunti, Kamlesh
Raindi, Devan
Marwaha, Steven
Hughes, Sarah E.
McMullan, Christel
Marshall, Tom
Calvert, Melanie J.
Haroon, Shamil
Aiyegbusi, Olalekan Lee
Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review
title Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review
title_full Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review
title_fullStr Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review
title_full_unstemmed Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review
title_short Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review
title_sort non-pharmacological therapies for post-viral syndromes, including long covid: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967466/
https://www.ncbi.nlm.nih.gov/pubmed/36834176
http://dx.doi.org/10.3390/ijerph20043477
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