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Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review
Background: Post-viral syndromes (PVS), including Long COVID, are symptoms sustained from weeks to years following an acute viral infection. Non-pharmacological treatments for these symptoms are poorly understood. This review summarises the evidence for the effectiveness of non-pharmacological treat...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967466/ https://www.ncbi.nlm.nih.gov/pubmed/36834176 http://dx.doi.org/10.3390/ijerph20043477 |
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author | Chandan, Joht Singh Brown, Kirsty R. Simms-Williams, Nikita Bashir, Nasir Z. Camaradou, Jenny Heining, Dominic Turner, Grace M. Rivera, Samantha Cruz Hotham, Richard Minhas, Sonica Nirantharakumar, Krishnarajah Sivan, Manoj Khunti, Kamlesh Raindi, Devan Marwaha, Steven Hughes, Sarah E. McMullan, Christel Marshall, Tom Calvert, Melanie J. Haroon, Shamil Aiyegbusi, Olalekan Lee |
author_facet | Chandan, Joht Singh Brown, Kirsty R. Simms-Williams, Nikita Bashir, Nasir Z. Camaradou, Jenny Heining, Dominic Turner, Grace M. Rivera, Samantha Cruz Hotham, Richard Minhas, Sonica Nirantharakumar, Krishnarajah Sivan, Manoj Khunti, Kamlesh Raindi, Devan Marwaha, Steven Hughes, Sarah E. McMullan, Christel Marshall, Tom Calvert, Melanie J. Haroon, Shamil Aiyegbusi, Olalekan Lee |
author_sort | Chandan, Joht Singh |
collection | PubMed |
description | Background: Post-viral syndromes (PVS), including Long COVID, are symptoms sustained from weeks to years following an acute viral infection. Non-pharmacological treatments for these symptoms are poorly understood. This review summarises the evidence for the effectiveness of non-pharmacological treatments for PVS. Methods: We conducted a systematic review to evaluate the effectiveness of non-pharmacological interventions for PVS, as compared to either standard care, alternative non-pharmacological therapy, or placebo. The outcomes of interest were changes in symptoms, exercise capacity, quality of life (including mental health and wellbeing), and work capability. We searched five databases (Embase, MEDLINE, PsycINFO, CINAHL, MedRxiv) for randomised controlled trials (RCTs) published between 1 January 2001 to 29 October 2021. The relevant outcome data were extracted, the study quality was appraised using the Cochrane risk-of-bias tool, and the findings were synthesised narratively. Findings: Overall, five studies of five different interventions (Pilates, music therapy, telerehabilitation, resistance exercise, neuromodulation) met the inclusion criteria. Aside from music-based intervention, all other selected interventions demonstrated some support in the management of PVS in some patients. Interpretation: In this study, we observed a lack of robust evidence evaluating the non-pharmacological treatments for PVS, including Long COVID. Considering the prevalence of prolonged symptoms following acute viral infections, there is an urgent need for clinical trials evaluating the effectiveness and cost-effectiveness of non-pharmacological treatments for patients with PVS. Registration: The study protocol was registered with PROSPERO [CRD42021282074] in October 2021 and published in BMJ Open in 2022. |
format | Online Article Text |
id | pubmed-9967466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99674662023-02-27 Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review Chandan, Joht Singh Brown, Kirsty R. Simms-Williams, Nikita Bashir, Nasir Z. Camaradou, Jenny Heining, Dominic Turner, Grace M. Rivera, Samantha Cruz Hotham, Richard Minhas, Sonica Nirantharakumar, Krishnarajah Sivan, Manoj Khunti, Kamlesh Raindi, Devan Marwaha, Steven Hughes, Sarah E. McMullan, Christel Marshall, Tom Calvert, Melanie J. Haroon, Shamil Aiyegbusi, Olalekan Lee Int J Environ Res Public Health Review Background: Post-viral syndromes (PVS), including Long COVID, are symptoms sustained from weeks to years following an acute viral infection. Non-pharmacological treatments for these symptoms are poorly understood. This review summarises the evidence for the effectiveness of non-pharmacological treatments for PVS. Methods: We conducted a systematic review to evaluate the effectiveness of non-pharmacological interventions for PVS, as compared to either standard care, alternative non-pharmacological therapy, or placebo. The outcomes of interest were changes in symptoms, exercise capacity, quality of life (including mental health and wellbeing), and work capability. We searched five databases (Embase, MEDLINE, PsycINFO, CINAHL, MedRxiv) for randomised controlled trials (RCTs) published between 1 January 2001 to 29 October 2021. The relevant outcome data were extracted, the study quality was appraised using the Cochrane risk-of-bias tool, and the findings were synthesised narratively. Findings: Overall, five studies of five different interventions (Pilates, music therapy, telerehabilitation, resistance exercise, neuromodulation) met the inclusion criteria. Aside from music-based intervention, all other selected interventions demonstrated some support in the management of PVS in some patients. Interpretation: In this study, we observed a lack of robust evidence evaluating the non-pharmacological treatments for PVS, including Long COVID. Considering the prevalence of prolonged symptoms following acute viral infections, there is an urgent need for clinical trials evaluating the effectiveness and cost-effectiveness of non-pharmacological treatments for patients with PVS. Registration: The study protocol was registered with PROSPERO [CRD42021282074] in October 2021 and published in BMJ Open in 2022. MDPI 2023-02-16 /pmc/articles/PMC9967466/ /pubmed/36834176 http://dx.doi.org/10.3390/ijerph20043477 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chandan, Joht Singh Brown, Kirsty R. Simms-Williams, Nikita Bashir, Nasir Z. Camaradou, Jenny Heining, Dominic Turner, Grace M. Rivera, Samantha Cruz Hotham, Richard Minhas, Sonica Nirantharakumar, Krishnarajah Sivan, Manoj Khunti, Kamlesh Raindi, Devan Marwaha, Steven Hughes, Sarah E. McMullan, Christel Marshall, Tom Calvert, Melanie J. Haroon, Shamil Aiyegbusi, Olalekan Lee Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review |
title | Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review |
title_full | Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review |
title_fullStr | Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review |
title_full_unstemmed | Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review |
title_short | Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review |
title_sort | non-pharmacological therapies for post-viral syndromes, including long covid: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967466/ https://www.ncbi.nlm.nih.gov/pubmed/36834176 http://dx.doi.org/10.3390/ijerph20043477 |
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