Cargando…

Factors Related to Plasma Homocysteine Concentration in Young Adults: A Retrospective Study Based on Checkup Populations

The distribution profile of plasma homocysteine (Hcy) in young adults and its related factors are not well understood. We performed a generalized estimating equations (GEE) analysis for plasma-Hcy-correlated factors in 2436 young adults, aged 20–39 years, from a health checkup population. We observe...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Zhihua, Zhao, Jing, Hou, Chengbei, Sun, Fei, Dong, Jing, Guo, Yansu, Chu, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967549/
https://www.ncbi.nlm.nih.gov/pubmed/36836190
http://dx.doi.org/10.3390/jcm12041656
_version_ 1784897292405309440
author Li, Zhihua
Zhao, Jing
Hou, Chengbei
Sun, Fei
Dong, Jing
Guo, Yansu
Chu, Xi
author_facet Li, Zhihua
Zhao, Jing
Hou, Chengbei
Sun, Fei
Dong, Jing
Guo, Yansu
Chu, Xi
author_sort Li, Zhihua
collection PubMed
description The distribution profile of plasma homocysteine (Hcy) in young adults and its related factors are not well understood. We performed a generalized estimating equations (GEE) analysis for plasma-Hcy-correlated factors in 2436 young adults, aged 20–39 years, from a health checkup population. We observed that the mean Hcy concentration in males (16.7 ± 10.3 μmol/L) was significantly higher than that in females (10.3 ± 4.0 μmol/L), and hyperhomocysteinemia (HHcy) prevalence in males was 5.37 times than that in females (33.3% vs. 6.2%). A GEE analysis stratified by sex indicated that age (B = −0.398, p < 0.001) and LDL-C (B = −1.602, p = 0.043) were negatively correlated, while BMI (B = 0.400, p = 0.042) was positively correlated, with the Hcy level in young males. ALT (B = −0.021, p = 0.033), LDL-C (B = −1.198, p < 0.001) and Glu (B = −0.446, p = 0.006) were negatively correlated, while AST (B = 0.022, p = 0.048), CREA (B = 0.035, p < 0.001), UA (B = 0.004, p = 0.003) and TG (B = 1.042, p < 0.001) were positively correlated, with the Hcy level in young females. These results suggest that young males have a significantly higher plasma Hcy level and HHcy prevalence than young females; therefore, more attention should be paid to the reason for and effect of the higher HHcy prevalence in young males.
format Online
Article
Text
id pubmed-9967549
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99675492023-02-27 Factors Related to Plasma Homocysteine Concentration in Young Adults: A Retrospective Study Based on Checkup Populations Li, Zhihua Zhao, Jing Hou, Chengbei Sun, Fei Dong, Jing Guo, Yansu Chu, Xi J Clin Med Brief Report The distribution profile of plasma homocysteine (Hcy) in young adults and its related factors are not well understood. We performed a generalized estimating equations (GEE) analysis for plasma-Hcy-correlated factors in 2436 young adults, aged 20–39 years, from a health checkup population. We observed that the mean Hcy concentration in males (16.7 ± 10.3 μmol/L) was significantly higher than that in females (10.3 ± 4.0 μmol/L), and hyperhomocysteinemia (HHcy) prevalence in males was 5.37 times than that in females (33.3% vs. 6.2%). A GEE analysis stratified by sex indicated that age (B = −0.398, p < 0.001) and LDL-C (B = −1.602, p = 0.043) were negatively correlated, while BMI (B = 0.400, p = 0.042) was positively correlated, with the Hcy level in young males. ALT (B = −0.021, p = 0.033), LDL-C (B = −1.198, p < 0.001) and Glu (B = −0.446, p = 0.006) were negatively correlated, while AST (B = 0.022, p = 0.048), CREA (B = 0.035, p < 0.001), UA (B = 0.004, p = 0.003) and TG (B = 1.042, p < 0.001) were positively correlated, with the Hcy level in young females. These results suggest that young males have a significantly higher plasma Hcy level and HHcy prevalence than young females; therefore, more attention should be paid to the reason for and effect of the higher HHcy prevalence in young males. MDPI 2023-02-19 /pmc/articles/PMC9967549/ /pubmed/36836190 http://dx.doi.org/10.3390/jcm12041656 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Li, Zhihua
Zhao, Jing
Hou, Chengbei
Sun, Fei
Dong, Jing
Guo, Yansu
Chu, Xi
Factors Related to Plasma Homocysteine Concentration in Young Adults: A Retrospective Study Based on Checkup Populations
title Factors Related to Plasma Homocysteine Concentration in Young Adults: A Retrospective Study Based on Checkup Populations
title_full Factors Related to Plasma Homocysteine Concentration in Young Adults: A Retrospective Study Based on Checkup Populations
title_fullStr Factors Related to Plasma Homocysteine Concentration in Young Adults: A Retrospective Study Based on Checkup Populations
title_full_unstemmed Factors Related to Plasma Homocysteine Concentration in Young Adults: A Retrospective Study Based on Checkup Populations
title_short Factors Related to Plasma Homocysteine Concentration in Young Adults: A Retrospective Study Based on Checkup Populations
title_sort factors related to plasma homocysteine concentration in young adults: a retrospective study based on checkup populations
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967549/
https://www.ncbi.nlm.nih.gov/pubmed/36836190
http://dx.doi.org/10.3390/jcm12041656
work_keys_str_mv AT lizhihua factorsrelatedtoplasmahomocysteineconcentrationinyoungadultsaretrospectivestudybasedoncheckuppopulations
AT zhaojing factorsrelatedtoplasmahomocysteineconcentrationinyoungadultsaretrospectivestudybasedoncheckuppopulations
AT houchengbei factorsrelatedtoplasmahomocysteineconcentrationinyoungadultsaretrospectivestudybasedoncheckuppopulations
AT sunfei factorsrelatedtoplasmahomocysteineconcentrationinyoungadultsaretrospectivestudybasedoncheckuppopulations
AT dongjing factorsrelatedtoplasmahomocysteineconcentrationinyoungadultsaretrospectivestudybasedoncheckuppopulations
AT guoyansu factorsrelatedtoplasmahomocysteineconcentrationinyoungadultsaretrospectivestudybasedoncheckuppopulations
AT chuxi factorsrelatedtoplasmahomocysteineconcentrationinyoungadultsaretrospectivestudybasedoncheckuppopulations