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Effects of Dietary Ferulic Acid on Intestinal Health and Ileal Microbiota of Tianfu Broilers Challenged with Lipopolysaccharide
Lipopolysaccharide (LPS) has been considered the primary agent to establish animal models of inflammation, immunological stress, and organ injury. Previous studies have demonstrated that LPS impaired gastrointestinal development and disrupted intestinal microbial composition and metabolism. Ferulic...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967589/ https://www.ncbi.nlm.nih.gov/pubmed/36838708 http://dx.doi.org/10.3390/molecules28041720 |
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author | Tang, Ziting Shu, Gang Du, Hong Zheng, Yilei Fu, Hualin Zhang, Wei Lv, Cheng Xu, Funeng Li, Haohuan Ouyang, Ping Lin, Juchun Chang, Li-Jen Amevor, Felix Kwame Zhao, Xiaoling |
author_facet | Tang, Ziting Shu, Gang Du, Hong Zheng, Yilei Fu, Hualin Zhang, Wei Lv, Cheng Xu, Funeng Li, Haohuan Ouyang, Ping Lin, Juchun Chang, Li-Jen Amevor, Felix Kwame Zhao, Xiaoling |
author_sort | Tang, Ziting |
collection | PubMed |
description | Lipopolysaccharide (LPS) has been considered the primary agent to establish animal models of inflammation, immunological stress, and organ injury. Previous studies have demonstrated that LPS impaired gastrointestinal development and disrupted intestinal microbial composition and metabolism. Ferulic acid (FA) isolated from multiple plants exhibits multiple biological activities. This study investigated whether FA ameliorated intestinal function and microflora in LPS-challenged Tianfu broilers. The results showed that LPS challenge impaired intestinal function, as evidenced by decreased antioxidant functions (p < 0.05), disrupted morphological structure (p < 0.05), and increased intestinal permeability (p < 0.05); however, these adverse effects were improved by FA supplementation. Additionally, FA supplementation preserved sIgA levels (p < 0.05), increased mRNA expression levels of CLDN and ZO-1 (p < 0.05), and enhanced epithelial proliferation (p < 0.05) in the ileal mucosa in LPS-challenged chickens. Moreover, FA supplementation rectified the ileal microflora disturbances in the LPS-challenged broilers. The results demonstrate that dietary FA supplementation decreased LPS-induced intestinal damage by enhancing antioxidant capacity and maintaining intestinal integrity. Furthermore, FA supplementation protects intestinal tight junctions (TJs), elevates secretory immunoglobulin A (sIgA) levels, and modulates ileal microflora composition in LPS-challenged broilers. |
format | Online Article Text |
id | pubmed-9967589 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99675892023-02-27 Effects of Dietary Ferulic Acid on Intestinal Health and Ileal Microbiota of Tianfu Broilers Challenged with Lipopolysaccharide Tang, Ziting Shu, Gang Du, Hong Zheng, Yilei Fu, Hualin Zhang, Wei Lv, Cheng Xu, Funeng Li, Haohuan Ouyang, Ping Lin, Juchun Chang, Li-Jen Amevor, Felix Kwame Zhao, Xiaoling Molecules Article Lipopolysaccharide (LPS) has been considered the primary agent to establish animal models of inflammation, immunological stress, and organ injury. Previous studies have demonstrated that LPS impaired gastrointestinal development and disrupted intestinal microbial composition and metabolism. Ferulic acid (FA) isolated from multiple plants exhibits multiple biological activities. This study investigated whether FA ameliorated intestinal function and microflora in LPS-challenged Tianfu broilers. The results showed that LPS challenge impaired intestinal function, as evidenced by decreased antioxidant functions (p < 0.05), disrupted morphological structure (p < 0.05), and increased intestinal permeability (p < 0.05); however, these adverse effects were improved by FA supplementation. Additionally, FA supplementation preserved sIgA levels (p < 0.05), increased mRNA expression levels of CLDN and ZO-1 (p < 0.05), and enhanced epithelial proliferation (p < 0.05) in the ileal mucosa in LPS-challenged chickens. Moreover, FA supplementation rectified the ileal microflora disturbances in the LPS-challenged broilers. The results demonstrate that dietary FA supplementation decreased LPS-induced intestinal damage by enhancing antioxidant capacity and maintaining intestinal integrity. Furthermore, FA supplementation protects intestinal tight junctions (TJs), elevates secretory immunoglobulin A (sIgA) levels, and modulates ileal microflora composition in LPS-challenged broilers. MDPI 2023-02-10 /pmc/articles/PMC9967589/ /pubmed/36838708 http://dx.doi.org/10.3390/molecules28041720 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tang, Ziting Shu, Gang Du, Hong Zheng, Yilei Fu, Hualin Zhang, Wei Lv, Cheng Xu, Funeng Li, Haohuan Ouyang, Ping Lin, Juchun Chang, Li-Jen Amevor, Felix Kwame Zhao, Xiaoling Effects of Dietary Ferulic Acid on Intestinal Health and Ileal Microbiota of Tianfu Broilers Challenged with Lipopolysaccharide |
title | Effects of Dietary Ferulic Acid on Intestinal Health and Ileal Microbiota of Tianfu Broilers Challenged with Lipopolysaccharide |
title_full | Effects of Dietary Ferulic Acid on Intestinal Health and Ileal Microbiota of Tianfu Broilers Challenged with Lipopolysaccharide |
title_fullStr | Effects of Dietary Ferulic Acid on Intestinal Health and Ileal Microbiota of Tianfu Broilers Challenged with Lipopolysaccharide |
title_full_unstemmed | Effects of Dietary Ferulic Acid on Intestinal Health and Ileal Microbiota of Tianfu Broilers Challenged with Lipopolysaccharide |
title_short | Effects of Dietary Ferulic Acid on Intestinal Health and Ileal Microbiota of Tianfu Broilers Challenged with Lipopolysaccharide |
title_sort | effects of dietary ferulic acid on intestinal health and ileal microbiota of tianfu broilers challenged with lipopolysaccharide |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967589/ https://www.ncbi.nlm.nih.gov/pubmed/36838708 http://dx.doi.org/10.3390/molecules28041720 |
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