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OAT3 Participates in Drug–Drug Interaction between Bentysrepinine and Entecavir through Interactions with M8—A Metabolite of Bentysrepinine—In Rats and Humans In Vitro
Bentysrepinine (Y101) is a novel phenylalanine dipeptide for the treatment of hepatitis B virus. Renal excretion played an important role in the elimination of Y101 and its metabolites, M8 and M9, in healthy Chinese subjects, although the molecular mechanisms of renal excretion and potential drug–dr...
Autores principales: | Zhang, Aijie, Yang, Fanlong, Yuan, Yang, Li, Cai, Huo, Xiaokui, Liu, Jing, Zhou, Shenzhi, Li, Wei, Zhang, Na, Liu, Jianfeng, Dong, Shiqi, Fan, Huirong, Peng, Ying, Zheng, Jiang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967645/ https://www.ncbi.nlm.nih.gov/pubmed/36838982 http://dx.doi.org/10.3390/molecules28041995 |
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