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Complement Activation Products in Patients with Chronic Schizophrenia

Evidence suggests a role of the immune system in the pathogenesis of a number of mental conditions, including schizophrenia (SCH). In terms of physiology, aside from its crucial protective function, the complement cascade (CC) is a critical element of the regeneration processes, including neurogenes...

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Autores principales: Rudkowski, Krzysztof, Waszczuk, Katarzyna, Tyburski, Ernest, Rek-Owodziń, Katarzyna, Plichta, Piotr, Podwalski, Piotr, Bielecki, Maksymilian, Mak, Monika, Michalczyk, Anna, Tarnowski, Maciej, Sielatycka, Katarzyna, Budkowska, Marta, Łuczkowska, Karolina, Dołęgowska, Barbara, Ratajczak, Mariusz Z., Samochowiec, Jerzy, Kucharska-Mazur, Jolanta, Sagan, Leszek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967657/
https://www.ncbi.nlm.nih.gov/pubmed/36836111
http://dx.doi.org/10.3390/jcm12041577
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author Rudkowski, Krzysztof
Waszczuk, Katarzyna
Tyburski, Ernest
Rek-Owodziń, Katarzyna
Plichta, Piotr
Podwalski, Piotr
Bielecki, Maksymilian
Mak, Monika
Michalczyk, Anna
Tarnowski, Maciej
Sielatycka, Katarzyna
Budkowska, Marta
Łuczkowska, Karolina
Dołęgowska, Barbara
Ratajczak, Mariusz Z.
Samochowiec, Jerzy
Kucharska-Mazur, Jolanta
Sagan, Leszek
author_facet Rudkowski, Krzysztof
Waszczuk, Katarzyna
Tyburski, Ernest
Rek-Owodziń, Katarzyna
Plichta, Piotr
Podwalski, Piotr
Bielecki, Maksymilian
Mak, Monika
Michalczyk, Anna
Tarnowski, Maciej
Sielatycka, Katarzyna
Budkowska, Marta
Łuczkowska, Karolina
Dołęgowska, Barbara
Ratajczak, Mariusz Z.
Samochowiec, Jerzy
Kucharska-Mazur, Jolanta
Sagan, Leszek
author_sort Rudkowski, Krzysztof
collection PubMed
description Evidence suggests a role of the immune system in the pathogenesis of a number of mental conditions, including schizophrenia (SCH). In terms of physiology, aside from its crucial protective function, the complement cascade (CC) is a critical element of the regeneration processes, including neurogenesis. Few studies have attempted to define the function of the CC components in SCH. To shed more light on this topic, we compared the levels of complement activation products (CAP) (C3a, C5a and C5b-9) in the peripheral blood of 62 patients with chronic SCH and disease duration of ≥ 10 years with 25 healthy controls matched for age, sex, BMI and smoking status. Concentrations of all the investigated CAP were elevated in SCH patients. However, after controlling for potential confounding factors, significant correlations were observed between SCH and C3a (M = 724.98 ng/mL) and C5a (M = 6.06 ng/mL) levels. In addition, multivariate logistic regression showed that C3a and C5b-9 were significant predictors of SCH. There were no significant correlations between any CAP and SCH symptom severity or general psychopathology in SCH patients. However, two significant links emerged between C3a and C5b-9 and global functioning. Increased levels of both complement activation products in the patient group as compared to healthy controls raise questions concerning the role of the CC in the etiology of SCH and further demonstrate dysregulation of the immune system in SCH patients.
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spelling pubmed-99676572023-02-27 Complement Activation Products in Patients with Chronic Schizophrenia Rudkowski, Krzysztof Waszczuk, Katarzyna Tyburski, Ernest Rek-Owodziń, Katarzyna Plichta, Piotr Podwalski, Piotr Bielecki, Maksymilian Mak, Monika Michalczyk, Anna Tarnowski, Maciej Sielatycka, Katarzyna Budkowska, Marta Łuczkowska, Karolina Dołęgowska, Barbara Ratajczak, Mariusz Z. Samochowiec, Jerzy Kucharska-Mazur, Jolanta Sagan, Leszek J Clin Med Article Evidence suggests a role of the immune system in the pathogenesis of a number of mental conditions, including schizophrenia (SCH). In terms of physiology, aside from its crucial protective function, the complement cascade (CC) is a critical element of the regeneration processes, including neurogenesis. Few studies have attempted to define the function of the CC components in SCH. To shed more light on this topic, we compared the levels of complement activation products (CAP) (C3a, C5a and C5b-9) in the peripheral blood of 62 patients with chronic SCH and disease duration of ≥ 10 years with 25 healthy controls matched for age, sex, BMI and smoking status. Concentrations of all the investigated CAP were elevated in SCH patients. However, after controlling for potential confounding factors, significant correlations were observed between SCH and C3a (M = 724.98 ng/mL) and C5a (M = 6.06 ng/mL) levels. In addition, multivariate logistic regression showed that C3a and C5b-9 were significant predictors of SCH. There were no significant correlations between any CAP and SCH symptom severity or general psychopathology in SCH patients. However, two significant links emerged between C3a and C5b-9 and global functioning. Increased levels of both complement activation products in the patient group as compared to healthy controls raise questions concerning the role of the CC in the etiology of SCH and further demonstrate dysregulation of the immune system in SCH patients. MDPI 2023-02-16 /pmc/articles/PMC9967657/ /pubmed/36836111 http://dx.doi.org/10.3390/jcm12041577 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rudkowski, Krzysztof
Waszczuk, Katarzyna
Tyburski, Ernest
Rek-Owodziń, Katarzyna
Plichta, Piotr
Podwalski, Piotr
Bielecki, Maksymilian
Mak, Monika
Michalczyk, Anna
Tarnowski, Maciej
Sielatycka, Katarzyna
Budkowska, Marta
Łuczkowska, Karolina
Dołęgowska, Barbara
Ratajczak, Mariusz Z.
Samochowiec, Jerzy
Kucharska-Mazur, Jolanta
Sagan, Leszek
Complement Activation Products in Patients with Chronic Schizophrenia
title Complement Activation Products in Patients with Chronic Schizophrenia
title_full Complement Activation Products in Patients with Chronic Schizophrenia
title_fullStr Complement Activation Products in Patients with Chronic Schizophrenia
title_full_unstemmed Complement Activation Products in Patients with Chronic Schizophrenia
title_short Complement Activation Products in Patients with Chronic Schizophrenia
title_sort complement activation products in patients with chronic schizophrenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967657/
https://www.ncbi.nlm.nih.gov/pubmed/36836111
http://dx.doi.org/10.3390/jcm12041577
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