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Melatonin in Dermatologic Allergic Diseases and Other Skin Conditions: Current Trends and Reports
Melatonin is the main hormone that regulates the sleep cycle, and it is mostly produced by the pineal gland from the amino acid tryptophan. It has cytoprotective, immunomodulatory, and anti-apoptotic effects. Melatonin is also one of the most powerful natural antioxidants, directly acting on free ra...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967801/ https://www.ncbi.nlm.nih.gov/pubmed/36835450 http://dx.doi.org/10.3390/ijms24044039 |
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author | Bešlić, Iva Lugović-Mihić, Liborija Vrtarić, Alen Bešlić, Ante Škrinjar, Ivana Hanžek, Milena Crnković, Danijel Artuković, Marinko |
author_facet | Bešlić, Iva Lugović-Mihić, Liborija Vrtarić, Alen Bešlić, Ante Škrinjar, Ivana Hanžek, Milena Crnković, Danijel Artuković, Marinko |
author_sort | Bešlić, Iva |
collection | PubMed |
description | Melatonin is the main hormone that regulates the sleep cycle, and it is mostly produced by the pineal gland from the amino acid tryptophan. It has cytoprotective, immunomodulatory, and anti-apoptotic effects. Melatonin is also one of the most powerful natural antioxidants, directly acting on free radicals and the intracellular antioxidant enzyme system. Furthermore, it participates in antitumor activity, hypopigmentation processes in hyperpigmentary disorders, anti-inflammatory, and immunomodulating activity in inflammatory dermatoses, maintaining the integrity of the epidermal barrier and thermoregulation of the body. Due predominantly to its positive influence on sleep, melatonin can be used in the treatment of sleep disturbances for those with chronic allergic diseases accompanied by intensive itching (such as atopic dermatitis and chronic spontaneous urticaria). According to the literature data, there are also many proven uses for melatonin in photoprotection and skin aging (due to melatonin’s antioxidant effects and role in preventing damage due to DNA repair mechanisms), hyperpigmentary disorders (e.g., melasma) and scalp diseases (such as androgenic alopecia and telogen effluvium). |
format | Online Article Text |
id | pubmed-9967801 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99678012023-02-27 Melatonin in Dermatologic Allergic Diseases and Other Skin Conditions: Current Trends and Reports Bešlić, Iva Lugović-Mihić, Liborija Vrtarić, Alen Bešlić, Ante Škrinjar, Ivana Hanžek, Milena Crnković, Danijel Artuković, Marinko Int J Mol Sci Review Melatonin is the main hormone that regulates the sleep cycle, and it is mostly produced by the pineal gland from the amino acid tryptophan. It has cytoprotective, immunomodulatory, and anti-apoptotic effects. Melatonin is also one of the most powerful natural antioxidants, directly acting on free radicals and the intracellular antioxidant enzyme system. Furthermore, it participates in antitumor activity, hypopigmentation processes in hyperpigmentary disorders, anti-inflammatory, and immunomodulating activity in inflammatory dermatoses, maintaining the integrity of the epidermal barrier and thermoregulation of the body. Due predominantly to its positive influence on sleep, melatonin can be used in the treatment of sleep disturbances for those with chronic allergic diseases accompanied by intensive itching (such as atopic dermatitis and chronic spontaneous urticaria). According to the literature data, there are also many proven uses for melatonin in photoprotection and skin aging (due to melatonin’s antioxidant effects and role in preventing damage due to DNA repair mechanisms), hyperpigmentary disorders (e.g., melasma) and scalp diseases (such as androgenic alopecia and telogen effluvium). MDPI 2023-02-17 /pmc/articles/PMC9967801/ /pubmed/36835450 http://dx.doi.org/10.3390/ijms24044039 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bešlić, Iva Lugović-Mihić, Liborija Vrtarić, Alen Bešlić, Ante Škrinjar, Ivana Hanžek, Milena Crnković, Danijel Artuković, Marinko Melatonin in Dermatologic Allergic Diseases and Other Skin Conditions: Current Trends and Reports |
title | Melatonin in Dermatologic Allergic Diseases and Other Skin Conditions: Current Trends and Reports |
title_full | Melatonin in Dermatologic Allergic Diseases and Other Skin Conditions: Current Trends and Reports |
title_fullStr | Melatonin in Dermatologic Allergic Diseases and Other Skin Conditions: Current Trends and Reports |
title_full_unstemmed | Melatonin in Dermatologic Allergic Diseases and Other Skin Conditions: Current Trends and Reports |
title_short | Melatonin in Dermatologic Allergic Diseases and Other Skin Conditions: Current Trends and Reports |
title_sort | melatonin in dermatologic allergic diseases and other skin conditions: current trends and reports |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967801/ https://www.ncbi.nlm.nih.gov/pubmed/36835450 http://dx.doi.org/10.3390/ijms24044039 |
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