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Employing T-Cell Memory to Effectively Target SARS-CoV-2
Well-trained T-cell immunity is needed for early viral containment, especially with the help of an ideal vaccine. Although most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected convalescent cases have recovered with the generation of virus-specific memory T cells, some cases hav...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967959/ https://www.ncbi.nlm.nih.gov/pubmed/36839573 http://dx.doi.org/10.3390/pathogens12020301 |
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author | Tun, Zaw Htet Htike, Nang Thinn Thinn Kyi-Tha-Thu, Chaw Lee, Wing-Hin |
author_facet | Tun, Zaw Htet Htike, Nang Thinn Thinn Kyi-Tha-Thu, Chaw Lee, Wing-Hin |
author_sort | Tun, Zaw Htet |
collection | PubMed |
description | Well-trained T-cell immunity is needed for early viral containment, especially with the help of an ideal vaccine. Although most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected convalescent cases have recovered with the generation of virus-specific memory T cells, some cases have encountered T-cell abnormalities. The emergence of several mutant strains has even threatened the effectiveness of the T-cell immunity that was established with the first-generation vaccines. Currently, the development of next-generation vaccines involves trying several approaches to educate T-cell memory to trigger a broad and fast response that targets several viral proteins. As the shaping of T-cell immunity in its fast and efficient form becomes important, this review discusses several interesting vaccine approaches to effectively employ T-cell memory for efficient viral containment. In addition, some essential facts and future possible consequences of using current vaccines are also highlighted. |
format | Online Article Text |
id | pubmed-9967959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99679592023-02-27 Employing T-Cell Memory to Effectively Target SARS-CoV-2 Tun, Zaw Htet Htike, Nang Thinn Thinn Kyi-Tha-Thu, Chaw Lee, Wing-Hin Pathogens Review Well-trained T-cell immunity is needed for early viral containment, especially with the help of an ideal vaccine. Although most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected convalescent cases have recovered with the generation of virus-specific memory T cells, some cases have encountered T-cell abnormalities. The emergence of several mutant strains has even threatened the effectiveness of the T-cell immunity that was established with the first-generation vaccines. Currently, the development of next-generation vaccines involves trying several approaches to educate T-cell memory to trigger a broad and fast response that targets several viral proteins. As the shaping of T-cell immunity in its fast and efficient form becomes important, this review discusses several interesting vaccine approaches to effectively employ T-cell memory for efficient viral containment. In addition, some essential facts and future possible consequences of using current vaccines are also highlighted. MDPI 2023-02-11 /pmc/articles/PMC9967959/ /pubmed/36839573 http://dx.doi.org/10.3390/pathogens12020301 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tun, Zaw Htet Htike, Nang Thinn Thinn Kyi-Tha-Thu, Chaw Lee, Wing-Hin Employing T-Cell Memory to Effectively Target SARS-CoV-2 |
title | Employing T-Cell Memory to Effectively Target SARS-CoV-2 |
title_full | Employing T-Cell Memory to Effectively Target SARS-CoV-2 |
title_fullStr | Employing T-Cell Memory to Effectively Target SARS-CoV-2 |
title_full_unstemmed | Employing T-Cell Memory to Effectively Target SARS-CoV-2 |
title_short | Employing T-Cell Memory to Effectively Target SARS-CoV-2 |
title_sort | employing t-cell memory to effectively target sars-cov-2 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967959/ https://www.ncbi.nlm.nih.gov/pubmed/36839573 http://dx.doi.org/10.3390/pathogens12020301 |
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