Cargando…
Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for Obtaining Tunable Customized Drug Delivery
Mesoporous silica (MPS) carriers are considered as a promising strategy to increase the solubility of poorly soluble drugs and to stabilize the amorphous drug delivery system. The development by the authors of a solvent-free method (milling-assisted loading, MAL) made it possible to manipulate the p...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968001/ https://www.ncbi.nlm.nih.gov/pubmed/36839712 http://dx.doi.org/10.3390/pharmaceutics15020390 |
_version_ | 1784897405847601152 |
---|---|
author | Moutamenni, Basma Tabary, Nicolas Mussi, Alexandre Dhainaut, Jeremy Ciotonea, Carmen Fadel, Alexandre Paccou, Laurent Dacquin, Jean-Philippe Guinet, Yannick Hédoux, Alain |
author_facet | Moutamenni, Basma Tabary, Nicolas Mussi, Alexandre Dhainaut, Jeremy Ciotonea, Carmen Fadel, Alexandre Paccou, Laurent Dacquin, Jean-Philippe Guinet, Yannick Hédoux, Alain |
author_sort | Moutamenni, Basma |
collection | PubMed |
description | Mesoporous silica (MPS) carriers are considered as a promising strategy to increase the solubility of poorly soluble drugs and to stabilize the amorphous drug delivery system. The development by the authors of a solvent-free method (milling-assisted loading, MAL) made it possible to manipulate the physical state of the drug within the pores. The present study focuses on the effects of the milling intensity and the pore architecture (chemical surface) on the physical state of the confined drug and its release profile. Ibuprofen (IBP) and SBA-15 were used as the model drug and the MPS carrier, respectively. It was found that decreasing the milling intensity promotes nanocrystallization of confined IBP. Scanning electron microscopy and low-frequency Raman spectroscopy investigations converged into a bimodal description of the size distribution of particles, by decreasing the milling intensity. The chemical modification of the pore surface with 3-aminopropyltriethoxisylane also significantly promoted nanocrystallization, regardless of the milling intensity. Combined analyses of drug release profiles obtained on composites prepared from unmodified and modified SBA-15 with various milling intensities showed that the particle size of composites has the greatest influence on the drug release profile. Tuning drug concentration, milling intensity, and chemical surface make it possible to easily customize drug delivery. |
format | Online Article Text |
id | pubmed-9968001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99680012023-02-27 Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for Obtaining Tunable Customized Drug Delivery Moutamenni, Basma Tabary, Nicolas Mussi, Alexandre Dhainaut, Jeremy Ciotonea, Carmen Fadel, Alexandre Paccou, Laurent Dacquin, Jean-Philippe Guinet, Yannick Hédoux, Alain Pharmaceutics Article Mesoporous silica (MPS) carriers are considered as a promising strategy to increase the solubility of poorly soluble drugs and to stabilize the amorphous drug delivery system. The development by the authors of a solvent-free method (milling-assisted loading, MAL) made it possible to manipulate the physical state of the drug within the pores. The present study focuses on the effects of the milling intensity and the pore architecture (chemical surface) on the physical state of the confined drug and its release profile. Ibuprofen (IBP) and SBA-15 were used as the model drug and the MPS carrier, respectively. It was found that decreasing the milling intensity promotes nanocrystallization of confined IBP. Scanning electron microscopy and low-frequency Raman spectroscopy investigations converged into a bimodal description of the size distribution of particles, by decreasing the milling intensity. The chemical modification of the pore surface with 3-aminopropyltriethoxisylane also significantly promoted nanocrystallization, regardless of the milling intensity. Combined analyses of drug release profiles obtained on composites prepared from unmodified and modified SBA-15 with various milling intensities showed that the particle size of composites has the greatest influence on the drug release profile. Tuning drug concentration, milling intensity, and chemical surface make it possible to easily customize drug delivery. MDPI 2023-01-24 /pmc/articles/PMC9968001/ /pubmed/36839712 http://dx.doi.org/10.3390/pharmaceutics15020390 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Moutamenni, Basma Tabary, Nicolas Mussi, Alexandre Dhainaut, Jeremy Ciotonea, Carmen Fadel, Alexandre Paccou, Laurent Dacquin, Jean-Philippe Guinet, Yannick Hédoux, Alain Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for Obtaining Tunable Customized Drug Delivery |
title | Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for Obtaining Tunable Customized Drug Delivery |
title_full | Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for Obtaining Tunable Customized Drug Delivery |
title_fullStr | Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for Obtaining Tunable Customized Drug Delivery |
title_full_unstemmed | Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for Obtaining Tunable Customized Drug Delivery |
title_short | Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for Obtaining Tunable Customized Drug Delivery |
title_sort | milling-assisted loading of drugs into mesoporous silica carriers: a green and simple method for obtaining tunable customized drug delivery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968001/ https://www.ncbi.nlm.nih.gov/pubmed/36839712 http://dx.doi.org/10.3390/pharmaceutics15020390 |
work_keys_str_mv | AT moutamennibasma millingassistedloadingofdrugsintomesoporoussilicacarriersagreenandsimplemethodforobtainingtunablecustomizeddrugdelivery AT tabarynicolas millingassistedloadingofdrugsintomesoporoussilicacarriersagreenandsimplemethodforobtainingtunablecustomizeddrugdelivery AT mussialexandre millingassistedloadingofdrugsintomesoporoussilicacarriersagreenandsimplemethodforobtainingtunablecustomizeddrugdelivery AT dhainautjeremy millingassistedloadingofdrugsintomesoporoussilicacarriersagreenandsimplemethodforobtainingtunablecustomizeddrugdelivery AT ciotoneacarmen millingassistedloadingofdrugsintomesoporoussilicacarriersagreenandsimplemethodforobtainingtunablecustomizeddrugdelivery AT fadelalexandre millingassistedloadingofdrugsintomesoporoussilicacarriersagreenandsimplemethodforobtainingtunablecustomizeddrugdelivery AT paccoulaurent millingassistedloadingofdrugsintomesoporoussilicacarriersagreenandsimplemethodforobtainingtunablecustomizeddrugdelivery AT dacquinjeanphilippe millingassistedloadingofdrugsintomesoporoussilicacarriersagreenandsimplemethodforobtainingtunablecustomizeddrugdelivery AT guinetyannick millingassistedloadingofdrugsintomesoporoussilicacarriersagreenandsimplemethodforobtainingtunablecustomizeddrugdelivery AT hedouxalain millingassistedloadingofdrugsintomesoporoussilicacarriersagreenandsimplemethodforobtainingtunablecustomizeddrugdelivery |