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Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for Obtaining Tunable Customized Drug Delivery

Mesoporous silica (MPS) carriers are considered as a promising strategy to increase the solubility of poorly soluble drugs and to stabilize the amorphous drug delivery system. The development by the authors of a solvent-free method (milling-assisted loading, MAL) made it possible to manipulate the p...

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Autores principales: Moutamenni, Basma, Tabary, Nicolas, Mussi, Alexandre, Dhainaut, Jeremy, Ciotonea, Carmen, Fadel, Alexandre, Paccou, Laurent, Dacquin, Jean-Philippe, Guinet, Yannick, Hédoux, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968001/
https://www.ncbi.nlm.nih.gov/pubmed/36839712
http://dx.doi.org/10.3390/pharmaceutics15020390
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author Moutamenni, Basma
Tabary, Nicolas
Mussi, Alexandre
Dhainaut, Jeremy
Ciotonea, Carmen
Fadel, Alexandre
Paccou, Laurent
Dacquin, Jean-Philippe
Guinet, Yannick
Hédoux, Alain
author_facet Moutamenni, Basma
Tabary, Nicolas
Mussi, Alexandre
Dhainaut, Jeremy
Ciotonea, Carmen
Fadel, Alexandre
Paccou, Laurent
Dacquin, Jean-Philippe
Guinet, Yannick
Hédoux, Alain
author_sort Moutamenni, Basma
collection PubMed
description Mesoporous silica (MPS) carriers are considered as a promising strategy to increase the solubility of poorly soluble drugs and to stabilize the amorphous drug delivery system. The development by the authors of a solvent-free method (milling-assisted loading, MAL) made it possible to manipulate the physical state of the drug within the pores. The present study focuses on the effects of the milling intensity and the pore architecture (chemical surface) on the physical state of the confined drug and its release profile. Ibuprofen (IBP) and SBA-15 were used as the model drug and the MPS carrier, respectively. It was found that decreasing the milling intensity promotes nanocrystallization of confined IBP. Scanning electron microscopy and low-frequency Raman spectroscopy investigations converged into a bimodal description of the size distribution of particles, by decreasing the milling intensity. The chemical modification of the pore surface with 3-aminopropyltriethoxisylane also significantly promoted nanocrystallization, regardless of the milling intensity. Combined analyses of drug release profiles obtained on composites prepared from unmodified and modified SBA-15 with various milling intensities showed that the particle size of composites has the greatest influence on the drug release profile. Tuning drug concentration, milling intensity, and chemical surface make it possible to easily customize drug delivery.
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spelling pubmed-99680012023-02-27 Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for Obtaining Tunable Customized Drug Delivery Moutamenni, Basma Tabary, Nicolas Mussi, Alexandre Dhainaut, Jeremy Ciotonea, Carmen Fadel, Alexandre Paccou, Laurent Dacquin, Jean-Philippe Guinet, Yannick Hédoux, Alain Pharmaceutics Article Mesoporous silica (MPS) carriers are considered as a promising strategy to increase the solubility of poorly soluble drugs and to stabilize the amorphous drug delivery system. The development by the authors of a solvent-free method (milling-assisted loading, MAL) made it possible to manipulate the physical state of the drug within the pores. The present study focuses on the effects of the milling intensity and the pore architecture (chemical surface) on the physical state of the confined drug and its release profile. Ibuprofen (IBP) and SBA-15 were used as the model drug and the MPS carrier, respectively. It was found that decreasing the milling intensity promotes nanocrystallization of confined IBP. Scanning electron microscopy and low-frequency Raman spectroscopy investigations converged into a bimodal description of the size distribution of particles, by decreasing the milling intensity. The chemical modification of the pore surface with 3-aminopropyltriethoxisylane also significantly promoted nanocrystallization, regardless of the milling intensity. Combined analyses of drug release profiles obtained on composites prepared from unmodified and modified SBA-15 with various milling intensities showed that the particle size of composites has the greatest influence on the drug release profile. Tuning drug concentration, milling intensity, and chemical surface make it possible to easily customize drug delivery. MDPI 2023-01-24 /pmc/articles/PMC9968001/ /pubmed/36839712 http://dx.doi.org/10.3390/pharmaceutics15020390 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moutamenni, Basma
Tabary, Nicolas
Mussi, Alexandre
Dhainaut, Jeremy
Ciotonea, Carmen
Fadel, Alexandre
Paccou, Laurent
Dacquin, Jean-Philippe
Guinet, Yannick
Hédoux, Alain
Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for Obtaining Tunable Customized Drug Delivery
title Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for Obtaining Tunable Customized Drug Delivery
title_full Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for Obtaining Tunable Customized Drug Delivery
title_fullStr Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for Obtaining Tunable Customized Drug Delivery
title_full_unstemmed Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for Obtaining Tunable Customized Drug Delivery
title_short Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for Obtaining Tunable Customized Drug Delivery
title_sort milling-assisted loading of drugs into mesoporous silica carriers: a green and simple method for obtaining tunable customized drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968001/
https://www.ncbi.nlm.nih.gov/pubmed/36839712
http://dx.doi.org/10.3390/pharmaceutics15020390
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