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Polyacrylamide Hydrogel Containing Calendula Extract as a Wound Healing Bandage: In Vivo Test

Hydrogel is a biomaterial widely used in several areas of industry due to its great biocompatibility and adaptability to biological tissues. In Brazil, the Calendula plant is approved by the Ministry of Health as a medicinal herb. It was chosen to be incorporated in the hydrogel formulation because...

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Autores principales: Ferreira, Lindalva Maria de Meneses Costa, Bandeira, Elanne de Sousa, Gomes, Maurício Ferreira, Lynch, Desireé Gyles, Bastos, Gilmara Nazareth Tavares, Silva-Júnior, José Otávio Carréra, Ribeiro-Costa, Roseane Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968031/
https://www.ncbi.nlm.nih.gov/pubmed/36835221
http://dx.doi.org/10.3390/ijms24043806
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author Ferreira, Lindalva Maria de Meneses Costa
Bandeira, Elanne de Sousa
Gomes, Maurício Ferreira
Lynch, Desireé Gyles
Bastos, Gilmara Nazareth Tavares
Silva-Júnior, José Otávio Carréra
Ribeiro-Costa, Roseane Maria
author_facet Ferreira, Lindalva Maria de Meneses Costa
Bandeira, Elanne de Sousa
Gomes, Maurício Ferreira
Lynch, Desireé Gyles
Bastos, Gilmara Nazareth Tavares
Silva-Júnior, José Otávio Carréra
Ribeiro-Costa, Roseane Maria
author_sort Ferreira, Lindalva Maria de Meneses Costa
collection PubMed
description Hydrogel is a biomaterial widely used in several areas of industry due to its great biocompatibility and adaptability to biological tissues. In Brazil, the Calendula plant is approved by the Ministry of Health as a medicinal herb. It was chosen to be incorporated in the hydrogel formulation because of its anti-inflammatory, antiseptic and healing effects. This study synthesized polyacrylamide hydrogel containing calendula extract and evaluated its efficiency as a bandage for wound healing. The hydrogels were prepared using free radical polymerization and characterized by Scanning Electron Microscopy, swelling analysis and mechanical properties by texturometer. The morphology of the matrices showed large pores and foliaceous structure. In vivo testing, as well as the evaluation of acute dermal toxicity, was conducted using male Wistar rats. The tests indicated efficient collagen fiber production, improved skin repair and no signs of dermal toxicity. Thus, the hydrogel presents compatible properties for the controlled release of calendula extract used as a bandage to promote cicatrization.
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spelling pubmed-99680312023-02-27 Polyacrylamide Hydrogel Containing Calendula Extract as a Wound Healing Bandage: In Vivo Test Ferreira, Lindalva Maria de Meneses Costa Bandeira, Elanne de Sousa Gomes, Maurício Ferreira Lynch, Desireé Gyles Bastos, Gilmara Nazareth Tavares Silva-Júnior, José Otávio Carréra Ribeiro-Costa, Roseane Maria Int J Mol Sci Communication Hydrogel is a biomaterial widely used in several areas of industry due to its great biocompatibility and adaptability to biological tissues. In Brazil, the Calendula plant is approved by the Ministry of Health as a medicinal herb. It was chosen to be incorporated in the hydrogel formulation because of its anti-inflammatory, antiseptic and healing effects. This study synthesized polyacrylamide hydrogel containing calendula extract and evaluated its efficiency as a bandage for wound healing. The hydrogels were prepared using free radical polymerization and characterized by Scanning Electron Microscopy, swelling analysis and mechanical properties by texturometer. The morphology of the matrices showed large pores and foliaceous structure. In vivo testing, as well as the evaluation of acute dermal toxicity, was conducted using male Wistar rats. The tests indicated efficient collagen fiber production, improved skin repair and no signs of dermal toxicity. Thus, the hydrogel presents compatible properties for the controlled release of calendula extract used as a bandage to promote cicatrization. MDPI 2023-02-14 /pmc/articles/PMC9968031/ /pubmed/36835221 http://dx.doi.org/10.3390/ijms24043806 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Ferreira, Lindalva Maria de Meneses Costa
Bandeira, Elanne de Sousa
Gomes, Maurício Ferreira
Lynch, Desireé Gyles
Bastos, Gilmara Nazareth Tavares
Silva-Júnior, José Otávio Carréra
Ribeiro-Costa, Roseane Maria
Polyacrylamide Hydrogel Containing Calendula Extract as a Wound Healing Bandage: In Vivo Test
title Polyacrylamide Hydrogel Containing Calendula Extract as a Wound Healing Bandage: In Vivo Test
title_full Polyacrylamide Hydrogel Containing Calendula Extract as a Wound Healing Bandage: In Vivo Test
title_fullStr Polyacrylamide Hydrogel Containing Calendula Extract as a Wound Healing Bandage: In Vivo Test
title_full_unstemmed Polyacrylamide Hydrogel Containing Calendula Extract as a Wound Healing Bandage: In Vivo Test
title_short Polyacrylamide Hydrogel Containing Calendula Extract as a Wound Healing Bandage: In Vivo Test
title_sort polyacrylamide hydrogel containing calendula extract as a wound healing bandage: in vivo test
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968031/
https://www.ncbi.nlm.nih.gov/pubmed/36835221
http://dx.doi.org/10.3390/ijms24043806
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